Model-based analysis and optimization of bioreactor for hematopoietic stem cell cultivation

Bioprocess and Biosystems Engineering

Volumn 34, Issue 1, 2011, Pages 81-93

  Kresnowati, M T A P ^a   Forde, G M ^a   Chen, X D ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Bioreactor; Feeding strategy; Hematopoietic stem cell; Modelling; Optimization

Indexed keywords

CELL CONCENTRATIONS; CELL YIELDS; DESIGN AND OPTIMIZATION; DEVELOPED MODEL; EX-VIVO; FEEDING STRATEGIES; FEEDING STRATEGY; HEMATOPOIETIC STEM CELLS; LABOUR-INTENSIVE; MODEL-BASED ANALYSIS; MODELLING; NUTRIENT DISTRIBUTIONS; NUTRIENT LIMITATIONS; OXYGEN CONCENTRATIONS; PERFUSION BIOREACTOR; STEM CELL; STEP CHANGES;

BIOCONVERSION; BIOREACTORS; CULTIVATION; FEEDING; MATHEMATICAL MODELS; NUTRIENTS; OPTIMIZATION; OXYGEN;

STEM CELLS;

OXYGEN;

ARTICLE; BIOREACTOR DESIGN; CELL CULTURE; CELL GROWTH; CELL HETEROGENEITY; CELL HYPOXIA; CELL METABOLISM; CELL POPULATION; CONTROLLED STUDY; CULTURE MEDIUM; EX VIVO STUDY; FED BATCH CULTURE; GROWTH RATE; HEMATOPOIETIC STEM CELL; MATHEMATICAL MODEL; MICHAELIS MENTEN KINETICS; MOLECULAR DYNAMICS; NUTRIENT CONCENTRATION; NUTRIENT LIMITATION; NUTRIENT UPTAKE; OXYGEN CONCENTRATION; OXYGEN SATURATION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS MODEL; REACTOR MONITORING; REACTOR OPERATION; REACTOR OPTIMIZATION; VALIDATION PROCESS;

ALGORITHMS; ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; COMPUTER SIMULATION; HEMATOPOIETIC STEM CELLS; HUMANS; MODELS, THEORETICAL; PERFUSION;

EID: 79251608193     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-010-0449-z     Document Type: Article

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