Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice

Obesity

Volumn 23, Issue 6, 2015, Pages 1209-1217

  Wang, Xianfeng ^a   Buechler, Nancy L ^a   Yoza, Barbara K ^a   McCall, Charles E ^a   Vachharajani, Vidula T ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; DIMETHYL SULFOXIDE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; RESVERATROL; SELISISTAT; SIRTUIN 1; SYNAPTOTAGMIN I; VON WILLEBRAND FACTOR; NONSTEROID ANTIINFLAMMATORY AGENT; STILBENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; HEALTH CARE UTILIZATION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTESTINE FUNCTION; LAPAROTOMY; LEUKOCYTE ADHERENCE; LEUKOCYTE COUNT; MEAN ARTERIAL PRESSURE; MODULATION; MORBIDITY; MOUSE; NONHUMAN; OBESITY; PROTEIN ACETYLATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEPSIS; SMALL INTESTINE; SURVIVAL; THROMBOCYTE ADHESION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CECUM; DRUG EFFECTS; FEMALE; MALE; METABOLISM; MOUSE MUTANT;

MUS; RICE STRIPE VIRUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CECUM; CELL ADHESION MOLECULES; FEMALE; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; PLATELET ADHESIVENESS; SEPSIS; SIRTUIN 1; STILBENES;

EID: 84929956328     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.21086     Document Type: Article

References (40)

1. Wang HE, Shapiro NI, Angus DC, Yealy DM,. National estimates of severe sepsis in United States emergency departments. Critical Care Med 2007; 35: 1928-1936.
2. Mayr FB, Yende S, Angus DC,. Epidemiology of severe sepsis. Virulence 2014; 5: 4-11.
3. Wood KA, Angus DC,. Pharmacoeconomic implications of new therapies in sepsis. PharmacoEconomics 2004; 22: 895-906.
4. Jung U, Norman KE, Scharffetter-Kochanek K, Beaudet AL, Ley K,. Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo. J Clin Investig 1998; 102: 1526-1533.
5. Singer G, Stokes KY, Terao S, Granger DN,. Sepsis-induced intestinal microvascular and inflammatory responses in obese mice. Shock 2009; 31: 275-279.
6. Vachharajani V, Russell JM, Scott KL, et al., Obesity exacerbates sepsis-induced inflammation and microvascular dysfunction in mouse brain. Microcirculation 2005; 12: 183-194.
7. Vachharajani V, Vital S, Russell J,. Modulation of circulating cell-endothelial cell interaction by erythropoietin in lean and obese mice with cecal ligation and puncture. Pathophysiology 2010; 17: 9-18.
8. Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M,. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 2011; 378: 815-825.
9. Arabi YM, Dara SI, Tamim HM, et al., Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study. Crit Care 2013; 17: R72.
10. Prescott HC, Chang VW, O'Brien JM, Jr., Langa KM, Iwashyna T,. Obesity and 1-Year Outcomes in Older Americans With Severe Sepsis. Critical Care Med 2014.
11. Akinnusi ME, Pineda LA, El Solh AA,. Effect of obesity on intensive care morbidity and mortality: a meta-analysis. Critical Care Med 2008; 36: 151-158.
12. Vachharajani VT, Fu Liu T, Brown CM, et al., SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. J Leukocyte Biol 2014.
13. Moschen AR, Wieser V, Gerner RR, et al., Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity. J Hepatol 2013; 59: 1315-1322.
14. Poulsen MM, Jorgensen JO, Jessen N, Richelsen B, Pedersen SB,. Resveratrol in metabolic health: an overview of the current evidence and perspectives. Ann N Y Acad Sci. 2013; 1290: 74-82.
15. Guo H, Chen Y, Liao L, Wu W,. Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway. Cardiovasc Drugs Ther 2013; 27: 189-198.
16. Liu LQ, Fan ZQ, Tang YF, Ke ZJ,. The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro. Alcoholism Clin Exp Res 2014; 38: 683-693.
17. Gomez-Zorita S, Fernandez-Quintela A, Lasa A, Hijona E, Bujanda L, Portillo MP,. Effects of resveratrol on obesity-related inflammation markers in adipose tissue of genetically obese rats. Nutrition 2013; 29: 1374-1380.
18. Li T, Zhang J, Feng J, et al., Resveratrol reduces acute lung injury in a LPSinduced sepsis mouse model via activation of Sirt1. Mol Med Rep 2013; 7: 1889-1895.
19. Yang SJ, Lim Y,. Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation. Metabolism 2014; 63: 693-701.
20. Holthoff JH, Wang Z, Seely KA, Gokden N, Mayeux PR,. Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury. Kidney Int 2012; 81: 370-378.
21. Kolgazi M, Sener G, Cetinel S, Gedik N, Alican I,. Resveratrol reduces renal and lung injury caused by sepsis in rats. J Surg Res 2006; 134: 315-321.
22. Ayala A, Deol ZK, Lehman DL, Herdon CD, Chaudry IH,. Does endotoxin play a major role in inducing the depression of macrophage function during polymicrobial sepsis? Arch Surg 1995; 130: 1178-1184; discussion 1184-1175.
23. Tailor A, Granger DN,. Hypercholesterolemia promotes P-selectin-dependent platelet-endothelial cell adhesion in postcapillary venules. Arteriosclerosis, Thrombosis, Vasc Biol 2003; 23: 675-680.
24. Vachharajani V, Cunningham C, Yoza B, Carson J, Jr,., Vachharajani TJ, McCall C., Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Obesity 2012; 20: 498-504.
25. Lin QQ, Yan CF, Lin R, et al., SIRT1 regulates TNF-alpha-induced expression of CD40 in 3T3-L1 adipocytes via NF-kappaB pathway. Cytokine 2012; 60: 447-455.
26. Camins A, Sureda FX, Junyent F, et al., Sirtuin activators: designing molecules to extend life span. Biochim Biophy Acta 2010; 1799: 740-749.
27. Costa Cdos S, Rohden F, Hammes TO, et al., Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARgamma1-3 mRNA expression in human visceral adipocytes. Obesity Surg 2011; 21: 356-361.
28. Hoyert DL, Xu J,. Deaths: preliminary data for 2011. National vital statistics reports. Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. 2012; 61: 1-51.
29. Eber MR, Laxminarayan R, Perencevich EN, Malani A,. Clinical and economic outcomes attributable to health care-associated sepsis and pneumonia. Arch Internal Med 2010; 170: 347-353.
30. Skibsted S, Jones AE, Puskarich MA, et al., Biomarkers of endothelial cell activation in early sepsis. Shock 2013; 39: 427-432.
31. Gertz M, Fischer F, Nguyen GT, et al., Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc Natl Acad Sci USA 2013; 110: E2772-E2781.
32. Sinclair DA, Guarente L,. Small-molecule allosteric activators of sirtuins. Ann Rev Pharmacol Toxicol 2014; 54: 363-380.
33. Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A,. Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal 2013; 25: 1939-1948.
34. Liu TF, Brown CM, El Gazzar M, et al., Fueling the flame: bioenergy couples metabolism and inflammation. J Leukocyte Biol 2012; 92: 499-507.
35. Yang H, Zhang W, Pan H, et al., SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-kappaB activity. PloS one. 2012; 7: e46364.
36. Ceolotto G, De Kreutzenberg SV, Cattelan A, et al., Sirtuin 1 stabilization by HuR represses TNF-alpha- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro: relevance to human metabolic syndrome. Clin Sci 2014; 127: 449-461.
37. Liu TF, Vachharajani VT, Yoza BK, McCall CE,. NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem 2012; 287: 25758-25769.
38. Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE,. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem 2011; 286: 9856-9864.
39. Kubota S, Ozawa Y, Kurihara T, et al., Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation. Investig Ophthalmol Vis Sci 2011; 52: 9142-9148.
40. Vachharajani V, Liu T, McCall CE. Epigenetic coordination of acute systemic inflammation: potential therapeutic targets. Exp Rev Clin Immunol 2014: 1-10.