Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain

Obesity

Volumn 20, Issue 3, 2012, Pages 498-504

  Vachharajani, Vidula ^a   Cunningham, Christie ^a   Yoza, Barbara ^a   Carson Jr , John ^a   Vachharajani, Tushar J ^a   McCall, Charles ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1;

ADIPONECTIN DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DYSFUNCTION; BRAIN MICROCIRCULATION; CELL INTERACTION; CONTROLLED STUDY; ISOTOPE LABELING; LEUKOCYTE ADHERENCE; LIGATION; MICROANGIOPATHY; MOUSE; NEUROMODULATION; NONHUMAN; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PUNCTURE; SEPSIS; THROMBOCYTE ADHESION; VIDEO MICROSCOPY;

ADIPONECTIN; ANIMALS; BLOOD-BRAIN BARRIER; CELL ADHESION; CEREBROVASCULAR CIRCULATION; CYTOKINES; E-SELECTIN; FLUORESCENCE; INFLAMMATION; LEUKOCYTES; MICE; MICE, INBRED C57BL; MICROCIRCULATION; MICROSCOPY; OBESITY; PLATELET ADHESIVENESS; RADIOIMMUNODETECTION; SEPSIS; VIDEO RECORDING;

MUS;

EID: 84857686155     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2011.316     Document Type: Article

References (37)

1. Miniño AM, Heron MP, Murphy SL, Kochanek KD; Centers for Disease Control and Prevention National Center for Health Statistics National Vital Statistics System. Deaths: final data for 2004. Natl Vital Stat Rep 2007;55:118-119.
2. Jung U, Norman KE, Scharffetter-Kochanek K, Beaudet AL, Ley K. Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo. J Clin Invest 1998;102:1526-1533.
3. Lush CW, Kvietys PR. Microvascular dysfunction in sepsis. Microcirculation 2000;7:83-101.
4. Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003;101:3765-3777.
5. Marshall JC, Cook DJ, Christou NV et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995;23:1638-1652.
6. Taccone FS, Su F, Pierrakos C et al. Cerebral microcirculation is impaired during sepsis: an experimental study. Crit Care 2010;14:R140.
7. Sharshar T, Carlier R, Bernard F et al. Brain lesions in septic shock: a magnetic resonance imaging study. Intensive Care Med 2007;33:798-806.
8. Sprung CL, Peduzzi PN, Shatney CH et al. Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. Crit Care Med 1990;18:801-806.
9. de Onis M, Blössner M, Borghi E. Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr 2010;92:1257-1264.
10. Yaegashi M, Jean R, Zuriqat M, Noack S, Homel P. Outcome of morbid obesity in the intensive care unit. J Intensive Care Med 2005;20:147-154.
11. Bercault N, Boulain T, Kuteifan K et al. Obesity-related excess mortality rate in an adult intensive care unit: A risk-adjusted matched cohort study. Crit Care Med 2004;32:998-1003.
12. Vachharajani V, Russell JM, Scott KL et al. Obesity exacerbates sepsisinduced inflammation and microvascular dysfunction in mouse brain. Microcirculation 2005;12:183-194.
13. Vachharajani V, Vital S, Russell J, Scott LK, Granger DN. Glucocorticoids inhibit the cerebral microvascular dysfunction associated with sepsis in obese mice. Microcirculation 2006;13:477-487.
14. Vachharajani V, Vital S, Russell J, Granger DN. Hypertonic saline and the cerebral microcirculation in obese septic mice. Microcirculation 2007;14:223-231.
15. Arita Y, Kihara S, Ouchi N et al. Paradoxical decrease of an adiposespecific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79-83.
16. Hillenbrand A, Knippschild U, Weiss M et al. Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients. BMC Surg 2010;10:26.
17. Venkatesh B, Hickman I, Nisbet J, Cohen J, Prins J. Changes in serum adiponectin concentrations in critical illness: a preliminary investigation. Crit Care 2009;13:R105.
18. Uji Y, Yamamoto H, Tsuchihashi H et al. Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality. Surgery 2009;145:550-557.
19. Teoh H, Quan A, Bang KW et al. Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. Am J Physiol Endocrinol Metab 2008;295:E658-E664.
20. Ouedraogo R, Gong Y, Berzins B et al. Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest 2007;117:1718-1726.
21. Ma K, Cabrero A, Saha PK et al. Increased beta-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem 2002;277:34658-34661.
22. Tailor A, Granger DN. Hypercholesterolemia promotes P-selectin-dependent platelet-endothelial cell adhesion in postcapillary venules. Arterioscler Thromb Vasc Biol 2003;23:675-680.
23. Tsujikawa A, Kiryu J, Yamashiro K et al. Interactions between blood cells and retinal endothelium in endotoxic sepsis. Hypertension 2000;36:250-258.
24. Esen F, Erdem T, Aktan D et al. Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study. Crit Care 2005;9:R18-R23.
25. Eppihimer MJ, Russell J, Anderson DC, Wolitzky BA, Granger DN. Endothelial cell adhesion molecule expression in gene-targeted mice. Am J Physiol 1997;273:H1903-H1908.
26. Panés J, Perry MA, Anderson DC et al. Regional differences in constitutive and induced ICAM-1 expression in vivo. Am J Physiol 1995;269:H1955-H1964.
27. Eppihimer MJ, Wolitzky B, Anderson DC, Labow MA, Granger DN. Heterogeneity of expression of E-and P-selectins in vivo. Circ Res 1996;79:560-569.
28. Russell J, Cooper D, Tailor A, Stokes KY, Granger DN. Low venular shear rates promote leukocyte-dependent recruitment of adherent platelets. Am J Physiol Gastrointest Liver Physiol 2003;284:G123-G129.
29. Bauer P, Lush CW, Kvietys PR, Russell JM, Granger DN. Role of endotoxin in the expression of endothelial selectins after cecal ligation and perforation. Am J Physiol Regul Integr Comp Physiol 2000;278:R1140-R1147.
30. Singer G, Stokes KY, Terao S, Granger DN. Sepsis-induced intestinal microvascular and inflammatory responses in obese mice. Shock 2009;31:275-279.
31. Vachharajani V, Vital S, Russell J. Modulation of circulating cell-endothelial cell interaction by erythropoietin in lean and obese mice with cecal ligation and puncture. Pathophysiology 2010;17:9-18.
32. Vachharajani V, Wang SW, Mishra N et al. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation 2010;17:407-416.
33. Hickey MJ, Kanwar S, McCafferty DM et al. Varying roles of E-selectin and P-selectin in different microvascular beds in response to antigen. J Immunol 1999;162:1137-1143.
34. Wood K, Russell J, Hebbel RP, Granger DN. Differential expression of E-and P-selectin in the microvasculature of sickle cell transgenic mice. Microcirculation 2004;11:377-385.
35. Spranger J, Verma S, Göhring I et al. Adiponectin does not cross the bloodbrain barrier but modifies cytokine expression of brain endothelial cells. Diabetes 2006;55:141-147.
36. Bhatwadekar AD, Glenn JV, Curtis TM et al. Retinal endothelial cell apoptosis stimulates recruitment of endothelial progenitor cells. Invest Ophthalmol Vis Sci 2009;50:4967-4973.
37. Trevaskis JL, Gawronska-Kozak B, Sutton GM et al. Role of adiponectin and inflammation in insulin resistance of Mc3r and Mc4r knockout mice. Obesity (Silver Spring) 2007;15:2664-2672.