-
1
-
-
0348048874
-
Diabetic retinopathy
-
Frank RN. Diabetic retinopathy. N Engl J Med. 2004;350:48-58.
-
(2004)
N Engl J Med
, vol.350
, pp. 48-58
-
-
Frank, R.N.1
-
2
-
-
0043125643
-
VEGF164-mediated inflammation is required for pathological, but not physiological, ischemiainduced retinal neovascularization
-
Ishida S, Usui T, Yamashiro K, et al. VEGF164-mediated inflammation is required for pathological, but not physiological, ischemiainduced retinal neovascularization. J Exp Med. 2003;198:483-489.
-
(2003)
J Exp Med
, vol.198
, pp. 483-489
-
-
Ishida, S.1
Usui, T.2
Yamashiro, K.3
-
4
-
-
0037902889
-
Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
-
Ishida S, Yamashiro K, Usui T, et al. Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease. Nat Med. 2003;9:781-788.
-
(2003)
Nat Med
, vol.9
, pp. 781-788
-
-
Ishida, S.1
Yamashiro, K.2
Usui, T.3
-
5
-
-
0032863021
-
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition
-
Miyamoto K, Khosrof S, Bursell SE, et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci U S A. 1999;96:10836-10841.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 10836-10841
-
-
Miyamoto, K.1
Khosrof, S.2
Bursell, S.E.3
-
6
-
-
7044228789
-
A central role for inflammation in the pathogenesis of diabetic retinopathy
-
Joussen AM, Poulaki V, Le ML, et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004;18: 1450-1452.
-
(2004)
FASEB J
, vol.18
, pp. 1450-1452
-
-
Joussen, A.M.1
Poulaki, V.2
Le, M.L.3
-
7
-
-
0031660311
-
In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats
-
Miyamoto K, Hiroshiba N, Tsujikawa A, Ogura Y. In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci. 1998;39:2190-2194.
-
(1998)
Invest Ophthalmol Vis Sci
, vol.39
, pp. 2190-2194
-
-
Miyamoto, K.1
Hiroshiba, N.2
Tsujikawa, A.3
Ogura, Y.4
-
8
-
-
0032543607
-
Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo
-
Bolton SJ, Anthony DC, Perry VH. Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo. Neuroscience. 1998;86:1245-1257.
-
(1998)
Neuroscience
, vol.86
, pp. 1245-1257
-
-
Bolton, S.J.1
Anthony, D.C.2
Perry, V.H.3
-
9
-
-
0027942607
-
Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
-
Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994;331:1480-1487.
-
(1994)
N Engl J Med
, vol.331
, pp. 1480-1487
-
-
Aiello, L.P.1
Avery, R.L.2
Arrigg, P.G.3
-
10
-
-
0029162588
-
Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid
-
McLeod DS, Lefer DJ, Merges C, Lutty GA. Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. Am J Pathol. 1995;147:642-653.
-
(1995)
Am J Pathol
, vol.147
, pp. 642-653
-
-
McLeod, D.S.1
Lefer, D.J.2
Merges, C.3
Lutty, G.A.4
-
11
-
-
77952089530
-
Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes
-
Sasaki M, Ozawa Y, Kurihara T, et al. Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes. Diabetologia. 2010;53:971-979.
-
(2010)
Diabetologia
, vol.53
, pp. 971-979
-
-
Sasaki, M.1
Ozawa, Y.2
Kurihara, T.3
-
12
-
-
35148898712
-
Suppression of diabetesinduced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway
-
Nagai N, Izumi-Nagai K, Oike Y, et al. Suppression of diabetesinduced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway. Invest Ophthalmol Vis Sci. 2007;48:4342-4350.
-
(2007)
Invest Ophthalmol Vis Sci
, vol.48
, pp. 4342-4350
-
-
Nagai, N.1
Izumi-Nagai, K.2
Oike, Y.3
-
13
-
-
9444224415
-
Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats
-
Kowluru RA, Odenbach S. Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes. 2004;53:3233-3238.
-
(2004)
Diabetes
, vol.53
, pp. 3233-3238
-
-
Kowluru, R.A.1
Odenbach, S.2
-
14
-
-
33745962138
-
Therapeutic potential of resveratrol: The in vivo evidence
-
Sinclair JABDA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discovery. 2006;5:493-506.
-
(2006)
Nat Rev Drug Discovery
, vol.5
, pp. 493-506
-
-
Sinclair, J.A.B.D.A.1
-
15
-
-
0027447124
-
Inhibition of human LDL oxidation by resveratrol
-
Frankel EN, Waterhouse AL, Kinsella JE. Inhibition of human LDL oxidation by resveratrol. Lancet. 1993;341:1103-1104.
-
(1993)
Lancet
, vol.341
, pp. 1103-1104
-
-
Frankel, E.N.1
Waterhouse, A.L.2
Kinsella, J.E.3
-
16
-
-
0031561513
-
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
-
Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997;275:218-220.
-
(1997)
Science
, vol.275
, pp. 218-220
-
-
Jang, M.1
Cai, L.2
Udeani, G.O.3
-
17
-
-
0035430177
-
Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes
-
Brakenhielm E, Cao R, Cao Y. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB J. 2001;15:1798-1800.
-
(2001)
FASEB J
, vol.15
, pp. 1798-1800
-
-
Brakenhielm, E.1
Cao, R.2
Cao, Y.3
-
18
-
-
0037184675
-
Resveratrol protects against global cerebral ischemic injury in gerbils
-
Wang Q, Xu J, Rottinghaus GE, et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res. 2002;958: 439-447.
-
(2002)
Brain Res
, vol.958
, pp. 439-447
-
-
Wang, Q.1
Xu, J.2
Rottinghaus, G.E.3
-
19
-
-
17144429302
-
Calorie restriction, SIRT1 and metabolism: Understanding longevity
-
Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol. 2005;6:298-305.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 298-2305
-
-
Bordone, L.1
Guarente, L.2
-
20
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425:191-196.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
-
21
-
-
67649946223
-
Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation
-
Kubota S, Kurihara T, Mochimaru H, et al. Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation. Invest Ophthalmol Vis Sci. 2009;50:3512-3519.
-
(2009)
Invest Ophthalmol Vis Sci
, vol.50
, pp. 3512-3519
-
-
Kubota, S.1
Kurihara, T.2
Mochimaru, H.3
-
22
-
-
77957369366
-
Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation
-
Kubota S, Kurihara T, Ebinuma M, et al. Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation. Am J Pathol. 2010;177:1725-1731.
-
(2010)
Am J Pathol
, vol.177
, pp. 1725-1731
-
-
Kubota, S.1
Kurihara, T.2
Ebinuma, M.3
-
23
-
-
77954268849
-
Resveratrol inhibits neuronal apoptosis and elevated Ca2_/calmodulin-dependent protein kinase II activity in diabetic mouse retina
-
Kim YH, Kim YS, Kang SS, Cho GJ, Choi WS. Resveratrol inhibits neuronal apoptosis and elevated Ca2+/calmodulin-dependent protein kinase II activity in diabetic mouse retina. Diabetes. 2010;59: 1825-1835.
-
(2010)
Diabetes
, vol.59
, pp. 1825-1835
-
-
Kim, Y.H.1
Kim, Y.S.2
Kang, S.S.3
Cho, G.J.4
Choi, W.S.5
-
24
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
-
Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol. 2007;8:774-785.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 774-7785
-
-
Hardie, D.G.1
-
25
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD_ metabolism and SIRT1 activity
-
Canto C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009;458:1056-1060.
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
-
26
-
-
77950348878
-
AMP-activated protein kinasedeficient mice are resistant to the metabolic effects of resveratrol
-
Um JH, Park SJ, Kang H, et al. AMP-activated protein kinasedeficient mice are resistant to the metabolic effects of resveratrol. Diabetes. 2010;59:554-563.
-
(2010)
Diabetes
, vol.59
, pp. 554-563
-
-
Um, J.H.1
Park, S.J.2
Kang, H.3
-
27
-
-
50649112638
-
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
-
Hou X, Xu S, Maitland-Toolan KA, et al. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. 2008;283:20015-20026.
-
(2008)
J Biol Chem
, vol.283
, pp. 20015-20026
-
-
Hou, X.1
Xu, S.2
Maitland-Toolan, K.A.3
-
29
-
-
77949552845
-
Resveratrol attenuates renal hypertrophy in early-stage diabetes by activating AMPK
-
Ding DF, You N, Wu XM, et al. Resveratrol attenuates renal hypertrophy in early-stage diabetes by activating AMPK. Am J Nephrol. 2010;31:363-374.
-
(2010)
Am J Nephrol
, vol.31
, pp. 363-374
-
-
Ding, D.F.1
You, N.2
Wu, X.M.3
-
30
-
-
77957567397
-
Downregulation of AMPK accompanies leucine-and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle
-
Saha AK, Xu XJ, Lawson E, et al. Downregulation of AMPK accompanies leucine-and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes. 2010;59: 2426-2434.
-
(2010)
Diabetes
, vol.59
, pp. 2426-2434
-
-
Saha, A.K.1
Xu, X.J.2
Lawson, E.3
-
31
-
-
46249092855
-
Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: Evidence for an adipose tissue-vascular loop
-
Devaraj S, Torok N, Dasu MR, Samols D, Jialal I. Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loop. Arterioscler Thromb Vasc Biol. 2008;28:1368-1374.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1368-1374
-
-
Devaraj, S.1
Torok, N.2
Dasu, M.R.3
Samols, D.4
Jialal, I.5
-
32
-
-
57749183407
-
Cilostazol inhibits cytokineinduced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells
-
Hattori Y, Suzuki K, Tomizawa A, et al. Cilostazol inhibits cytokineinduced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells. Cardiovasc Res. 2009;81:133-139.
-
(2009)
Cardiovasc Res
, vol.81
, pp. 133-139
-
-
Hattori, Y.1
Suzuki, K.2
Tomizawa, A.3
-
33
-
-
77953517927
-
Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
-
Yang Z, Kahn BB, Shi H, Xue BZ. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem. 2010;285:19051-19059.
-
(2010)
J Biol Chem
, vol.285
, pp. 19051-19059
-
-
Yang, Z.1
Kahn, B.B.2
Shi, H.3
Xue, B.Z.4
-
34
-
-
52649141738
-
Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
-
Zhao X, Zmijewski JW, Lorne E, et al. Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008;295:L497-L504.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.295
-
-
Zhao, X.1
Zmijewski, J.W.2
Lorne, E.3
-
35
-
-
1642499162
-
5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: A possible role of AMP-activated protein kinase
-
Giri S, Nath N, Smith B, Viollet B, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci. 2004;24:479-487.
-
(2004)
J Neurosci
, vol.24
, pp. 479-487
-
-
Giri, S.1
Nath, N.2
Smith, B.3
Viollet, B.4
Singh, A.K.5
Singh, I.6
-
36
-
-
63249112836
-
Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway
-
Lee JH, Song MY, Song EK, et al. Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes. 2009;58:344-351.
-
(2009)
Diabetes
, vol.58
, pp. 344-351
-
-
Lee, J.H.1
Song, M.Y.2
Song, E.K.3
-
37
-
-
38849199203
-
Shared principles in NF-kappaB signaling
-
Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell. 2008;132:344-362.
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
38
-
-
34548487143
-
Beyond IkappaBs: Alternative regulation of NF-kappaB activity
-
Neumann M, Naumann M. Beyond IkappaBs: alternative regulation of NF-kappaB activity. FASEB J. 2007;21:2642-2654.
-
(2007)
FASEB J
, vol.21
, pp. 2642-2654
-
-
Neumann, M.1
Naumann, M.2
-
39
-
-
0031939649
-
Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat
-
Hammes HP, Lin J, Bretzel RG, Brownlee M, Breier G. Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat. Diabetes. 1998;47:401-406.
-
(1998)
Diabetes
, vol.47
, pp. 401-406
-
-
Hammes, H.P.1
Lin, J.2
Bretzel, R.G.3
Brownlee, M.4
Breier, G.5
-
40
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne JC, Lambert PD, Schenk S, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007;450:712-716.
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
|