Obesity and 1-year outcomes in older Americans with severe sepsis

Critical Care Medicine

Volumn 42, Issue 8, 2014, Pages 1766-1774

  Prescott, Hallie C ^a   Chang, Virginia W ^b   O'Brien, James M ^c   Langa, Kenneth M ^a,d,e   Iwashyna, Theodore J ^a,d,e  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c RIVERSIDE METHODIST HOSPITAL   (United States)

^d HSR and D Center of Excellence   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

body mass index; critical care; outcomes assessment; prognosis; sepsis; utilization

Indexed keywords

AGED; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; CRITICAL ILLNESS; DISEASE SEVERITY; DOSE RESPONSE; FEMALE; FUNCTIONAL STATUS; HEALTH CARE FACILITY; HEALTH CARE UTILIZATION; HOSPITAL DISCHARGE; HOSPITAL READMISSION; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MEDICARE; MORTALITY; OBESITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PATIENT CARE; PRIORITY JOURNAL; SEPSIS; VERY ELDERLY; COMORBIDITY; ECONOMICS; HEALTH CARE COST; HEALTH CARE DELIVERY; MIDDLE AGED; STATISTICS AND NUMERICAL DATA; SURVIVAL RATE; SURVIVOR; UNITED STATES; UTILIZATION;

AGED; AGED, 80 AND OVER; BODY MASS INDEX; COHORT STUDIES; COMORBIDITY; CRITICAL ILLNESS; DELIVERY OF HEALTH CARE; FEMALE; HEALTH EXPENDITURES; HOSPITALIZATION; HUMANS; MALE; MEDICARE; MIDDLE AGED; OBESITY; SEPSIS; SURVIVAL RATE; SURVIVORS; UNITED STATES;

EID: 84904768658     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000336     Document Type: Article

References (57)

1. Mokdad AH, Serdula MK, Dietz WH, et al: The spread of the obesity epidemic in the United States, 1991-1998. JAMA 1999; 282:1519-1522
2. Wang Y, Beydoun MA: The obesity epidemic in the United States-Gender, age, socioeconomic, racial/ethnic, and geographic characteristics: A systematic review and meta-regression analysis. Epidemiol Rev 2007; 29:6-28
3. Wang YC, Colditz GA, Kuntz KM: Forecasting the obesity epidemic in the aging U.S. population. Obesity (Silver Spring) 2007; 15:2855-2865
4. Iwashyna TJ, Cooke CR, Wunsch H, et al: Population burden of long-term survivorship after severe sepsis in older Americans. J Am Geriatr Soc 2012; 60:1070-1077
5. Thompson D, Edelsberg J, Colditz GA, et al: Lifetime health and economic consequences of obesity. Arch Intern Med 1999; 159:2177-2183
6. Flegal KM, Graubard BI, Williamson DF, et al: Excess deaths associated with underweight, overweight, and obesity. JAMA 2005; 293:1861-1867
7. Flegal KM, Kit BK, Orpana H, et al: Association of all-cause mortality with overweight and obesity using standard body mass index categories: A systematic review and meta-analysis. JAMA 2013; 309:71-82
8. Mehta NK, Chang VW: Mortality attributable to obesity among middle-aged adults in the United States. Demography 2009; 46:851-872
9. Kahn BB, Flier JS: Obesity and insulin resistance. J Clin Invest 2000; 106:473-481
10. Yang R, Barouch LA: Leptin signaling and obesity: Cardiovascular consequences. Circ Res 2007; 101:545-559
11. Caballero AE: Endothelial dysfunction in obesity and insulin resistance: A road to diabetes and heart disease. Obes Res 2003; 11:1278-1289
12. Yudkin JS, Stehouwer CD, Emeis JJ, et al: C-reactive protein in healthy subjects: Associations with obesity, insulin resistance, and endothelial dysfunction: A potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999; 19:972-978
13. Singer G, Granger DN: Infammatory responses underlying the microvascular dysfunction associated with obesity and insulin resistance. Microcirculation 2007; 14:375-387
14. Akinnusi ME, Pineda LA, El Solh AA: Effect of obesity on intensive care morbidity and mortality: A meta-analysis. Crit Care Med 2008; 36:151-158
15. Oliveros H, Villamor E: Obesity and mortality in critically ill adults: A systematic review and meta-analysis. Obesity (Silver Spring) 2008; 16:515-521
16. Hogue CW Jr, Stearns JD, Colantuoni E, et al: The impact of obesity on outcomes after critical illness: A meta-analysis. Intensive Care Med 2009; 35:1152-1170
17. O'Brien JM Jr, Philips GS, Ali NA, et al: The association between body mass index, processes of care, and outcomes from mechanical ventilation: A prospective cohort study. Crit Care Med 2012; 40:1456-1463
18. Hall WB, Wllis LE, Medvedev S, et al: The implications of long-term acute care hospital transfer practices for measures of in-hospital mortality and length of stay. Am J Respir Crit Care Med 2012; 185:53-57
19. Vasilevskis EE, Kuzniewicz MW, Dean ML, et al: Relationship between discharge practices and intensive care unit in-hospital mortality performance: Evidence of a discharge bias. Med Care 2009; 47:803-812
20. Kahn JM, Werner RM, Carson SS, et al: Variation in long-term acute care hospital use after intensive care. Med Care Res Rev 2012; 69:339-350
21. Gershengorn HB, Iwashyna TJ, Cooke CR, et al: Variation in use of intensive care for adults with diabetic ketoacidosis. Crit Care Med 2012; 40:2009-2015
22. Seymour CW, Iwashyna TJ, Ehlenbach WJ, et al: Hospital-level variation in the use of intensive care. Health Serv Res 2012; 47:2060-2080
23. Fried TR, Bradley EH, Towle VR, et al: Understanding the treatment preferences of seriously ill patients. N Engl J Med 2002; 346:1061-1066
24. Elixhauser A, Friedman B, Stranges E: Septicemia in U.S. Hospitals, 2009. HCUP Statistical Brief #122. October, 2011. Rockville, MD, Agency for Healthcare Research and Quality. Available at: http://www.hcup-us.ahrq.gov/ reports/statbriefs/sb122.pdf. Accessed January 23, 2013
25. Health and Retirement Study. Available at: http://hrsonline.isr.umich. edu/. Accessed October 18, 2012
26. IwashynaTJ, Ely EW, Smith DM, et al: Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 2010; 304:1787-1794
27. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
28. Iwashyna TJ, Odden A, Rohde J, et al: Identifying patients with severe sepsis using administrative claims: Patient-level validation of the Angus implementation of the international consensus conference defnition of severe sepsis. Med Care 2012 Sep 18. [Epub ahead of print]
29. Deyo RA, Cherkin DC, Ciol MA: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45:613-619
30. Esper AM, Moss M, Martin GS: The effect of diabetes mellitus on organ dysfunction with sepsis: An epidemiological study. Crit Care 2009; 13:R18
31. Quan H, Parsons GA, Ghali WA: Validity of procedure codes in International Classifcation of Diseases, 9th revision, clinical modifcation administrative data. Med Care 2004; 42:801-809
32. Wunsch H, Linde-Zwirble WT, Angus DC, et al: The epidemiology of mechanical ventilation use in the United States. Crit Care Med 2010; 38:1947-1953
33. Fonda S, Herzog AR: Documentation of Physical Functioning Measured in the Health and Retirement Study and the Asset and Health Dynamics among the Oldest Old Study. Survey Research Center, University of Michigan, Ann Arbor, MI, 2004
34. RAND Income and Wealth Imputation Files: RAND Center for the Study of Aging. Available at: http://hrsonline.isr.umich.edu/modules/meta/rand/READM E-incwlth.pdf. Accessed March 12, 2013
35. U.S. Department of Commerce Bureau of Economic Analysis Website. 2012. Available at: http://www.bea.gov/iTable/iTable. cfm?ReqID=9&step=1. Accessed November 27, 2012
36. Hajat A, Kaufman JS, Rose KM, et al: Do the wealthy have a health advantage? Cardiovascular disease risk factors and wealth. Soc Sci Med 2010; 71:1935-1942
37. Iwashyna TJ: On the detection of nursing home use in Medicare claims. Health Serv Outcomes Res Methodol 2003; 4:187-196
38. Yun H, Kilgore ML, Curtis JR, et al: Identifying types of nursing facilities using Medicare claims data: An algorithm and validation. Health Serv Outcomes Res Methodol 2010; 10:100-110
39. BMI Classifcation: World Health Organization. 2013. Available at: http://apps.who.int/bmi/index.jsp?introPage=intro-3.html. Accessed March 5, 2013
40. Finkielman JD, Gajic O, Afessa B: Underweight is independently associated with mortality in post-operative and non-operative patients admitted to the intensive care unit: A retrospective study. BMC Emerg Med 2004; 4:3
41. O'Brien JM Jr, Phillips GS, Ali NA, et al: Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med 2006; 34:738-744
42. Cuzick J. A Wilcoxon-type test for trend. Stat Med 1985; 4:87-90
43. Diehr P, Bild DE, Harris TB, et al: Body mass index and mortality in nonsmoking older adults: The Cardiovascular Health Study. Am J Public Health 1998; 88:623-629
44. Bender R, Jöckel KH, Trautner C, et al: Effect of age on excess mortality in obesity. JAMA 1999; 281:1498-1504
45. Stevens J, Cai J, Pamuk ER, et al: The effect of age on the association between body-mass index and mortality. N Engl J Med 1998; 338:1-7
46. Peake SL, Moran JL, Ghelani DR, et al: The effect of obesity on 12-month survival following admission to intensive care: A prospective study. Crit Care Med 2006; 34:2929-2939
47. Abhyankar S, Leishear K, Callaghan FM, et al: Lower short-and long-term mortality associated with overweight and obesity in a large cohort study of adult intensive care unit patients. Crit Care 2012; 16:R235
48. Arabi YM, Dara SI, Tamim HM, et al; The Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group: Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: An international multicenter cohort study. Crit Care 2013; 17:R72
49. O'Brien JM Jr, Aberegg SK, Ali NA, et al: Results from the national sepsis practice survey: Predictions about mortality and morbidity and recommendations for limitation of care orders. Crit Care 2009; 13:R96
50. Stapleton RD, Dixon AE, Parsons PE, et al: The association between body mass index and plasma cytokine levels in patients with acute lung injury. Chest 2010; 138:568-577
51. Herridge MS, Cheung AM, Tansey CM, et al; Canadian Critical Care Trials Group: One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003; 348:683-693
52. Druml W, Metnitz B, Schaden E, et al: Impact of body mass on incidence and prognosis of acute kidney injury requiring renal replacement therapy. Intensive Care Med 2010; 36:1221-1228
53. Shashaty MG, Meyer NJ, Localio AR, et al: African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients. J Crit Care 2012; 27:496-504
54. Soto GJ, Frank AJ, Christiani DC, et al: Body mass index and acute kidney injury in the acute respiratory distress syndrome. Crit Care Med 2012; 40:2601-2608
55. Lone NI, Walsh TS: Impact of intensive care unit organ failures on mortality during the fve years after a critical illness. Am J Respir Crit Care Med 2012; 186:640-647
56. Chang VW, Asch DA, Werner RM: Quality of care among obese patients. JAMA 2010; 303:1274-1281
57. Meng H, He XZ, Dixon D: Self-reported versus measured height and weight in the health and retirement study. J Am Geriatr Soc 2010; 58:412-413