Vasculogenesis and angiogenesis in nonseminomatous testicular germ cell tumors

Urologic Oncology: Seminars and Original Investigations

Volumn 33, Issue 6, 2015, Pages 268.e17-268.e28

  Silván, Unai ^a,b   Díez Torre, Alejandro ^a   Bonilla, Zuriñe ^a   Moreno, Pablo ^a   Díaz Núñez, María ^a   Aréchaga, Juan ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Angiogenesis; Teratocarcinoma; Teratoma; Testicular germ cell tumor; TGCT; Tumor derived endothelial cell; Vascularization; Vasculogenesis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN I; ANGIOTENSIN II; CHEMOKINE RECEPTOR CXCR4; CISPLATIN; ENDOCRINE GLAND DERIVED VASCULAR ENDOTHELIAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR LIKE DOMAIN 7; GEFITINIB; GELATINASE A; GELATINASE B; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; KRUPPEL LIKE FACTOR 4; PLACENTAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; RESVERATROL; SOMATOMEDIN; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN E; VASCULOTROPIN F; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; CARCINOMA IN SITU; CELL AGGREGATION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CYTOKINE RELEASE; EMBRYOID BODY; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; EPITHELIAL MESENCHYMAL TRANSITION; GERM CELL; GONAD; HISTOLOGY; HUMAN; HYPOXIA; IMMUNOCOMPETENT CELL; LEYDIG CELL; MALE; METASTASIS; NEOVASCULARIZATION (PATHOLOGY); NON SEMINOMATOUS GERMINOMA; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCANNING ELECTRON MICROSCOPY; SEMINIFEROUS TUBULE; TESTIS DEVELOPMENT; TESTIS FUNCTION; TESTIS TERATOMA; TUMOR GROWTH; TUMOR INVASION; TUMOR MICROENVIRONMENT; UPREGULATION; BLOOD; MORTALITY; NEOPLASM; PATHOLOGY; TESTIS TUMOR;

CELL DIFFERENTIATION; HUMANS; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; NEOVASCULARIZATION, PATHOLOGIC; TESTICULAR NEOPLASMS;

EID: 84929944535     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2015.01.005     Document Type: Review

References (60)

1. Fallon R., Olshan A., Saxman S. Male genital tract cancer. Cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival: 1975-2000 2001, 155-162. National Cancer Institute, NIH Publications, Bethesda. A. Bleyer, M. O'Leary, R. Barr, L.A.G. Ries (Eds.).
2. Oosterhuis J.W., Looijenga L.H. Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 2005, 5:210-222.
3. Almstrup K., Sonne S.B., Hoei-Hansen C.E., Ottesen A.M., Nielsen J.E., Skakkebaek N.E., et al. From embryonic stem cells to testicular germ cell cancer-should we be concerned?. Int J Androl 2006, 29:211-218.
4. Patan S. Vasculogenesis and angiogenesis. Cancer Treat Res 2004, 117:3-32.
5. Folberg R., Pe'er J., Gruman L.M., Woolson R.F., Jeng G., Montague P.R., et al. The morphologic characteristics of tumor blood vessels as a marker of tumor progression in primary human uveal melanoma: a matched case-control study. Hum Pathol 1992, 23:1298-1305.
6. Lissbrant I.F., Lissbrant E., Persson A., Damber J.E., Bergh A. Endothelial cell proliferation in male reproductive organs of adult rat is high and regulated by testicular factors. Biol Reprod 2003, 68:1107-1111.
7. Silván U., Díez-Torre A., Jiménez-Rojo L., Aréchaga J. Vascularization of testicular germ cell tumours: evidence from experimental teratocarcinomas. Int J Androl 2010, 33:765-774. 10.1111/j.1365-2605.2010.01068.x.
8. Ziyad S., Iruela-Arispe M.L. Molecular mechanisms of tumor angiogenesis. Genes Cancer 2011, 2:1085-1096. 10.1177/1947601911432334.
9. Ferrara N., Carver-Moore K., Chen H., Dowd M., Lu L., O'Shea K.S., et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996, 380:439-442.
10. Silván U., Díez-Torre A., Andrade R., Arluzea J., Silió M., Aréchaga J. Embryonic stem cell transplantation into seminiferous tubules: a model for the study of invasive germ cell tumors of the testis. Cell Transplant 2011, 20:637-642. 10.3727/096368910X536581.
11. Silván U., Arlucea J., Andrade R., Díez-Torre A., Silió M., Konerding M.A., et al. Angiogenesis and vascular network of teratocarcinoma from embryonic stem cell transplant into seminiferous tubules. Br J Cancer 2009, 101:64-70. 10.1038/sj.bjc.6605125.
12. Otranto M., Sarrazy V., Bonté F., Hinz B., Gabbiani G., Desmoulière A. The role of the myofibroblast in tumor stroma remodeling. Cell Adhes Migration 2012, 6:203-219. 10.4161/cam.20377.
13. Flenkenthaler F., Windschüttl S., Fröhlich T., Schwarzer J.U., Mayerhofer A., Arnold G.J. Secretome analysis of testicular peritubular cells: a window into the human testicular microenvironment and the spermatogonial stem cell niche in man. J Proteome Res 2014, 13:1259-1269. 10.1021/pr400769z.
14. Chiarenza C., Filippini A., Tripiciano A., Beccari E., Palombi F. Platelet-derived growth factor-BB stimulates hypertrophy of peritubular smooth muscle cells from rat testis in primary cultures. Endocrinology 2000, 141:2971-2981.
15. Svechnikov K., Petersen C., Sultana T., Wahlgren A., Zetterström C., Colón E., et al. The paracrine role played by interleukin-1 alpha in the testis. Curr Drug Targets Immune Endocr Metabol Disord 2004, 4:67-74.
16. Schell C., Albrecht M., Mayer C., Schwarzer J.U., Frungieri M.B., Mayerhofer A. Exploring human testicular peritubular cells: identification of secretory products and regulation by tumor necrosis factor-alpha. Endocrinology 2008, 149:1678-1686. 10.1210/en.2007-1064.
17. Mayerhofer A. Human testicular peritubular cells: more than meets the eye. Reproduction 2013, 1455:107-116.
18. Maragoudakis M.E., Missirlis E., Karakiulakis G.D., Sarmonica M., Bastakis M., Tsopanoglou N. Basement membrane biosynthesis as a target for developing inhibitors of angiogenesis with anti-tumor properties. Kidney Int 1993, 43:147-150.
19. Hawinkels L.J., Zuidwijk K., Verspaget H.W., de Jonge-Muller E.S., van Duijn W., Ferreira V., et al. VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis. Eur J Cancer 2008, 44:1904-1913. 10.1016/j.ejca.2008.06.031.
20. Banerjee I., Fuseler J.W., Souders C.A., Bowers S.L., Baudino T.A. The role of interleukin-6 in the formation of the coronary vasculature. Microsc Microanal 2009, 15:415-421. 10.1158/1078-0432.CCR-09-0287.
21. Shinriki S., Jono H., Ota K., Ueda M., Kudo M., Ota T., et al. Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma. Clin Cancer Res 2009, 15:5426-5434. 10.1158/1078-0432.CCR-09-0287.
22. Fan Y., Ye J., Shen F., Zhu Y., Yeghiazarians Y., Zhu W., et al. Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab 2008, 28:90-98.
23. Tzeng H.E., Tsai C.H., Chang Z.L., Su C.M., Wang S.W., Hwang W.L., et al. Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. Biochem Pharmacol 2012, 85:531-540. 10.1016/j.bcp.2012.11.021.
24. Sunderkötter C., Goebeler M., Schulze-Osthoff K., Bhardwaj R., Sorg C. Macrophage-derived angiogenesis factors. Pharmacol Ther 1991, 51:195-216.
25. Chen P., Huang Y., Bong R., Ding Y., Song N., Wang X., et al. Tumor-associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner. Clin Cancer Res 2011, 17:7230-7239. 10.1158/1078-0432.CCR-11-1354.
26. Riabov V., Gudima A., Wang N., Mickley A., Orekhov A., Kzhyshkowska J. Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis. Front Physiol 2014, 5:75. 10.3389/fphys.2014.00075.
27. Giraudo E., Inoue M., Hanahan D. An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest 2004, 114:623-633.
28. Wu X., Schulte B.C., Zhou Y., Haribhai D., Mackinnon A.C., Plaza J.A., et al. Depletion of M2-Like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo. J Invest Dermatol 2014, 29. 10.1038/jid.2014.206.
29. Nichol D., Stuhlmann H. EGFL7: a unique angiogenic signaling factor in vascular development and disease. Blood 2012, 119:1345-1352. 10.1182/blood-2011-10-322446.
30. Badiwala M.V., Tumiati L.C., Joseph J.M., Sheshgiri R., Ross H.J., Delgado D.H., et al. Epidermal growth factor-like domain 7 suppresses intercellular adhesion molecule 1 expression in response to hypoxia/reoxygenation injury in human coronary artery endothelial cells. Circulation 2010, 122:156-161. 10.1161/CIRCULATIONAHA.109.927715.
31. Campagnolo L., Moscatelli I., Pellegrini M., Siracusa G., Stuhlmann H. Expression of EGFL7 in primordial germ cells and in adult ovaries and testes. Gene Expr Patterns 2008, 8:389-396. 10.1016/j.gep.2008.05.001.
32. Godmann M., Gashaw I., Katz J.P., Nagy A., Kaestner K.H., Behr R. Krüppel-like factor 4, a "pluripotency transcription factor" highly expressed in male postmeiotic germ cells, is dispensable for spermatogenesis in the mouse. Mech Dev 2009, 126:650-664. 10.1016/j.mod.2009.06.1081.
33. Maeng Y.S., Choi H.J., Kwon J.Y., Park Y.W., Choi K.S., Min J.K., et al. Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis. Blood 2009, 113:233-243. 10.1182/blood-2008-06-162891.
34. Silván U., Díez-Torre A., Arluzea J., Andrade R., Silió M., Aréchaga J. Hypoxia and pluripotency in embryonic and embryonal carcinoma stem cell biology. Differentiation 2009, 78:159-168. 10.1016/j.diff.2009.06.002.
35. Pudliszewski M., Pardanaud L. Vasculogenesis and angiogenesis in the mouse embryo studied using quail/mouse chimeras. Int J Dev Biol 2005, 49:355-361.
36. Coveney D., Cool J., Oliver T., Capel B. Four-dimensional analysis of vascularization during primary development of an organ, the gonad. Proc Natl Acad Sci U S A 2008, 105:7212-7217. 10.1073/pnas.0707674105.
37. Timmins N.E., Dietmair S., Nielsen L.K. Hanging-drop multicellular spheroids as a model of tumour angiogenesis. Angiogenesis 2004, 7:97-103.
38. Silván U., Díez-Torre A., Jiménez-Rojo L., Aréchaga J. Embryonic and cancer stem cells, two views of the same landscape. Embryonic stem cells-recent advances in pluripotent stem cell-based regenerative medicine 2011, 371-398. InTech Open Access Publisher, Vienna. C. Atwood (Ed.).
39. Gerecht-Nir S., Dazard J.E., Golan-Mashiach M., Osenberg S., Botvinnik A., Amariglio N., et al. Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells. Dev Dyn 2005, 232:487-497.
40. Gerecht-Nir S., Osenberg S., Nevo O., Ziskind A., Coleman R., Itskovitz-Eldor J. Vascular development in early human embryos and in teratomas derived from human embryonic stem cells. Biol Reprod 2004, 71:2029-2036.
41. Risau W., Sariola H., Zerwes H.G., Sasse J., Ekblom P., Kemler R., et al. Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies. Development 1988, 102:471-478.
42. Krah K., Mironov V., Risau W., Flamme I. Induction of vasculogenesis in quail blastodisc-derived embryoid bodies. Dev Biol 1994, 164:123-132.
43. Silván U., Díez-Torre A., Moreno P., Arluzea J., Andrade R., Silió M., et al. The spermatogonial stem cell niche in testicular germ cell tumors. Int J Dev Biol 2013, 57:185-195. 10.1387/ijdb.130068ja.
44. Komarova N.L., Mironov V. On the role of endothelial progenitor cells in tumor neovascularization. J Theor Biol 2005, 235:338-349.
45. Chen JJ, Lin Y-H, Chiang C-S, Hong J-H, Yeh C-K. Characterization of tumor vasculature derived from angiogenesis and vasculogenesis by high-frequency three-dimensional doppler ultrasound. International ultrasonics symposium 2010;2319-2322.
46. Skowroński A., Jedrzejewski K. The human testicular artery and the pampiniform plexus--where is the connection?. Folia Morphol (Warsz) 2003, 62:201-204.
47. Nacov E. Tumor angiogenesis formation of vessels de novo at germ cell tumors. Cancer 1990, 669:916-922.
48. Shamloo A., Heilshorn S.C. Matrix density mediates polarization and lumen formation of endothelial sprouts in VEGF gradients. Lab Chip 2010, 10:3061-3068. 10.1039/c005069e.
49. Critser P.J., Kreger S.T., Voytik-Harbin S.L., Yoder M.C. Collagen matrix physical properties modulate endothelial colony forming cell-derived vessels in vivo. Microvasc Res 2010, 80:23-30. 10.1016/j.mvr.2010.03.001.
50. Chouinard-Pelletier G., Jahnsen E.D., Jones E.A. Increased shear stress inhibits angiogenesis in veins and not arteries during vascular development. Angiogenesis 2013, 16:71-83. 10.1007/s10456-012-9300-2.
51. Rössler J., Dietrich T., Pavlakovic H., Schweigerer L., Havers W., Schüler A., et al. Higher vessel densities in retinoblastoma with local invasive growth and metastasis. Am J Pathol 2004, 164:391-394.
52. Labropoulou V.T., Skandalis S.S., Ravazoula P., Perimenis P., Karamanos N.K., Kalofonos H.P., et al. Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours. Biomed Res Int 2013, 214864. 10.1155/2013/214864.
53. Goel S., Duda D.G., Xu L., Munn L.L., Boucher Y., Fukumura D., et al. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 2011, 91:1071-1121. 10.1152/physrev.00038.2010.
54. Tian F., Liang P.H., Li L.Y. Inhibition of endothelial progenitor cell differentiation by VEGI. Blood 2009, 113:5352-5360. 10.1182/blood-2008-08-173773.
55. Yang J.X., Chen B., Pan Y.Y., Han J., Chen F., Hu S.J. Zoledronate attenuates angiogenic effects of angiotensin II-stimulated endothelial progenitor cells via RhoA and MAPK signaling. PLoS One 2012, 7:e46511. 10.1371/journal.pone.0046511.
56. Castillo-Avila W., Piulats J.M., Garcia Del Muro X., Vidal A., Condom E., Casanovas O., et al. Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors. Clin Cancer Res 2009, 15:3384-3395. 10.1158/1078-0432.CCR-08-2170.
57. Berndorff D., Borkowski S., Sieger S., Rother A., Friebe M., Viti F., et al. Radioimmunotherapy of solid tumors by targeting extra domain B fibronectin: identification of the best-suited radioimmunoconjugate. Clin Cancer Res 2005, 11:7053-7063.
58. Trapp V., Parmakhtiar B., Papazian V., Willmott L., Fruehauf J.P. Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture. Angiogenesis 2010, 13:305-315. 10.1007/s10456-010-9187-8.
59. Ciardiello F., Caputo R., Bianco R., Damiano V., Fontanini G., Cuccato S., et al. Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res 2001, 7:1459-1465.
60. Nitzsche B., Gloesenkamp C., Schrader M., Ocker M., Preissner R., Lein M., et al. Novel compounds with antiangiogenic and antiproliferative potency for growth control of testicular germ cell tumours. Br J Cancer 2010, 103:18-28. 10.1038/sj.bjc.6605725.