Exploring human testicular peritubular cells: Identification of secretory products and regulation by tumor necrosis factor-α

Endocrinology

Volumn 149, Issue 4, 2008, Pages 1678-1686

  Schell, Christoph ^a   Albrecht, Martin ^a   Mayer, Christine ^a   Schwarzer, J Ullrich ^b   Frungieri, Monica B ^c   Mayerhofer, Artur ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b Department of Urology   (Germany)

^c INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYCLOOXYGENASE 2; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; NERVE GROWTH FACTOR; PROSTAGLANDIN D2; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ARTICLE; CELL CULTURE; CELL INFILTRATION; CELL ISOLATION; CONTROLLED STUDY; CYTOARCHITECTURE; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; INFLAMMATION; INNERVATION; MACROPHAGE; MAST CELL; MICROARRAY ANALYSIS; MYOFIBROBLAST; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPERMATOGENESIS; TESTIS; WESTERN BLOTTING;

CHEMOKINE CCL2; CYCLOOXYGENASE 2; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEMINIFEROUS TUBULES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 41549144843     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1064     Document Type: Article

References (56)

1. Davidoff MS, Breucker H, Holstein AF, Seidl K 1990 Cellular architecture of the lamina propria of human seminiferous tubules. Cell Tissue Res 262:253-261
2. Rossi F, Ferraresi A, Romagni P, Silvestroni L, Santiemma V 2002 Angiotensin II stimulates contraction and growth of testicular peritubular myoid cells in vitro. Endocrinology 143:3096-3104
3. Santiemma V, Beligotti F, Magnanti M, Palleschi S, Silvestroni L, Fabbrini A 1996 Endothelin-1 stimulates deoxyribonucleic acid synthesis and contraction in testicular peritubular myoid cells. Biol Reprod 54:583-590
4. Middendorff R, Muller D, Wichers S, Holstein AF, Davidoff MS 1997 Evidence for production and functional activity of nitric oxide in seminiferous tubules and blood vessels of the human testis. J Clin Endocrinol Metab 82:4154-4161
5. Maekawa M, Kamimura K, Nagano T 1996 Peritubular myoid cells in the testis: their structure and function. Arch Histol Cytol 59:1-13
6. Skinner MK, McLachlan RI, Bremner WJ 1989 Stimulation of Sertoli cell inhibin secretion by the testicular paracrine factor PModS. Mol Cell Endocrinol 66:239-249
7. Verhoeven G, Hoeben E, De Gendt K 2000 Peritubular cell-Sertoli cell interactions: factors involved in PmodS activity. Andrologia 32:42-45
8. Scott HM, Hutchison GR, Mahood IK, Hallmark N, Welsh M, De Gendt K, Verhoeven G, O'Shaughnessy P, Sharpe RM 2007 Role of androgens in fetal testis development and dysgenesis. Endocrinology 148:2027-2036
9. Schuppe HC, Meinhardt A 2005 Immune privilege and inflammation of the testis. Chem Immunol Allergy 88:1-14
10. Haider SG, Talati J, Servos G 1999 Ultrastructure of peritubular tissue in association with tubular hyalinization in human testis. Tissue Cell 31:90-98
11. Gulkesen KH, Erdogru T, Sargin CF, Karpuzoglu G 2002 Expression of extracellular matrix proteins and vimentin in testes of azoospermic man: an immunohistochemical and morphometric study. Asian J Androl 4:55-60
12. Frungieri MB, Calandra RS, Lustig L, Meineke V, Kohn FM, Vogt HJ, Mayerhofer A 2002 Number, distribution pattern, and identification of macrophages in the testes of infertile men. Fertil Steril 78:298-306
13. Frungieri MB, Weidinger S, Meineke V, Kohn FM, Mayerhofer A 2002 Proliferative action of mast-cell tryptase is mediated by PAR2, COX-2, prostaglandins, and PPARγ: possible relevance to human fibrotic disorders. Proc Natl Acad Sci USA 99:15072-15077
14. Meineke V, Frungieri MB, Jessberger B, Vogt H, Mayerhofer A 2000 Human testicular mast cells contain tryptase: increased mast cell number and altered distribution in the testes of infertile men. Fertil Steril 74:239-244
15. Cigorraga SB, Chemes H, Pellizzari E 1994 Steroidogenic and morphogenic characteristics of human peritubular cells in culture. Biol Reprod 51:1193-1205
16. Magnanti M, Gismondi A, Gandini O, Rossi FM, Michetti PM, Santiemma V, Morrone S 2001 Integrin pattern and effect on contraction in cultured testicular peritubular myoid cells. Am J Reprod Immunol 45:21-27
17. Albrecht M, Ramsch R, Kohn FM, Schwarzer JU, Mayerhofer A 2006 Isolation and cultivation of human testicular peritubular cells: a new model for the investigation of fibrotic processes in the human testis and male infertility. J Clin Endocrinol Metab 91:1956-1960
18. Mayerhofer A, Frungieri MB, Fritz S, Bulling A, Jessberger B, Vogt HJ 1999 Evidence for catecholaminergic, neuronlike cells in the adult human testis: changes associated with testicular pathologies. J Androl 20:341-347
19. Apa DD, Cayan S, Polat A, Akbay E 2002 Mast cells and fibrosis on testicular biopsies in male infertility. Arch Androl 48:337-344
20. Hussein MR, Abou-Deif ES, Bedaiwy MA, Said TM, Mustafa MG, Nada E, Ezat A, Agarwal A 2005 Phenotypic characterization of the immune and mast cell infiltrates in the human testis shows normal and abnormal spermatogenesis. Fertil Steril 83:1447-1453
21. Mukhopadhyay S, Hoidal JR, Mukherjee TK 2006 Role of TNFα in pulmonary pathophysiology. Respir Res 7:125
22. Pucilowska JB, Williams KL, Lund PK 2000 Fibrogenesis. IV. Fibrosis and inflammatory bowel disease: cellular mediators and animal models. Am J Physiol Gastrointest Liver Physiol 279:G653-G659
23. Frungieri MB, Albrecht M, Raemsch R, Mayerhofer A 2005 The action of the mast cell product tryptase on cyclooxygenase-2 (COX-2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2). Cell Signal 17:525-533
24. Schell C, Frungieri MB, Albrecht M, Gonzalez-Calvar SI, Kohn FM, Calandra RS, Mayerhofer A 2007 A prostaglandin D2 system in the human testis. Fertil Steril 88:233-236
25. Theiss AL, Simmons JG, Jobin C, Lund PK 2005 Tumor necrosis factor (TNF) α increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem 280:36099-36109
26. Li X, Strauss L, Kaatrasalo A, Mayerhofer A, Huhtaniemi I, Santti R, Makela S, Poutanen M 2006 Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis. Endocrinology 147:1271-1277
27. Marinoni E, Di Iorio R, Villaccio B, Vellucci O, Di Netta T, Sessa M, Letizia C, Cosmi EV 2005 Adrenomedullin in human male reproductive system. Eur J Obstet Gynecol Reprod Biol 122:195-198
28. Piquet-Pellorce C, Dorval-Coiffec I, Pham MD, Jegou B 2000 Leukemia inhibitory factor expression and regulation within the testis. Endocrinology 141:1136-1141
29. Suominen JS, Wang Y, Kaipia A, Toppari J 2004 Tumor necrosis factor-α (TNF-α) promotes cell survival during spermatogenesis, and this effect can be blocked by infliximab, a TNF-α antagonist. Eur J Endocrinol 151:629-640
30. Nockher WA, Renz H 2006 Neurotrophins in allergic diseases: from neuronal growth factors to intercellular signaling molecules. J Allergy Clin Immunol 117:583-589
31. Groneberg DA, Serowka F, Peckenschneider N, Artuc M, Grutzkau A, Fischer A, Henz BM, Welker P 2005 Gene expression and regulation of nerve growth factor in atopic dermatitis mast cells and the human mast cell line-1. J Neuroimmunol 161:87-92
32. Cupp AS, Kim GH, Skinner MK 2000 Expression and action of neurotropin-3 and nerve growth factor in embryonic and early postnatal rat testis development. Biol Reprod 63:1617-1628
33. Micera A, Puxeddu I, Aloe L, Levi-Schaffer F 2003 New insights on the involvement of nerve growth factor in allergic inflammation and fibrosis. Cytokine Growth Factor Rev 14:369-374
34. Perrard MH, Vigier M, Damestoy A, Chapat C, Silandre D, Rudkin BB, Durand P 2007 β-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes. J Cell Physiol 210:51-62
35. Micera A, Puxeddu I, Lambiase A, Antonelli A, Bonini S, Bonini S, Aloe L, Pe'er J, Levi-Schaffer F 2005 The pro-fibrogenic effect of nerve growth factor on conjunctival fibroblasts is mediated by transforming growth factor-β. Clin Exp Allergy 35:650-656
36. Ayer-LeLievre C, Olson L, Ebendal T, Hallbook F, Persson H 1988 Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat. Proc Natl Acad Sci USA 85:2628-2632
37. Jin W, Arai KY, Shimizu K, Kojima C, Itoh M, Watanabe G, Taya K 2006 Cellular localization of NGF and its receptors trkA and p75LNGFR in male reproductive organs of the Japanese monkey, Macaca fuscata fuscata. Endocrine 29:155-160
38. Muller D, Davidoff MS, Bargheer O, Paust HJ, Pusch W, Koeva Y, Jezek D, Holstein AF, Middendorff R 2006 The expression of neurotrophins and their receptors in the prenatal and adult human testis: evidence for functions in Leydig cells. Histochem Cell Biol 126:199-211
39. Russo MA, Odorisio T, Fradeani A, Rienzi L, De Felici M, Cattaneo A, Siracusa G 1994 Low-affinity nerve growth factor receptor is expressed during testicular morphogenesis and in germ cells at specific stages of spermatogenesis. Mol Reprod Dev 37:157-166
40. Seidl K, Holstein AF 1990 Evidence for the presence of nerve growth factor (NGF) and NGF receptors in human testis. Cell Tissue Res 261:549-554
41. Parvinen M, Pelto-Huikko M, Soder O, Schultz R, Kaipia A, Mali P, Toppari J, Hakovirta H, Lonnerberg P, Ritzen EM 1992 Expression of β-nerve growth factor and its receptor in rat seminiferous epithelium: specific function at the onset of meiosis. J Cell Biol 117:629-641
42. Persson H, Ayer-Le Lievre C, Soder O, Villar MJ, Metsis M, Olson L, Ritzen M, Hokfelt T 1990 Expression of β-nerve growth factor receptor mRNA in Sertoli cells downregulated by testosterone. Science 247:704-707
43. Bonini S, Rasi G, Bracci-Laudiero ML, Procoli A, Aloe L 2003 Nerve growth factor: neurotrophin or cytokine? Int Arch Allergy Immunol 131:80-84
44. Dissen GA, Parrott JA, Skinner MK, Hill DF, Costa ME, Ojeda SR 2000 Direct effects of nerve growth factor on thecal cells from antral ovarian follicles. Endocrinology 141:4736-4750
45. Salas C, Julio-Pieper M, Valladares M, Pommer R, Vega M, Mastronardi C, Kerr B, Ojeda SR, Lara HE, Romero C 2006 Nerve growth factor-dependent activation of trkA receptors in the human ovary results in synthesis of follicle-stimulating hormone receptors and estrogen secretion. J Clin Endocrinol Metab 91:2396-2403
46. Shi Z, Jin W, Watanabe G, Suzuki AK, Takahashi S, Taya K 2004 Expression of nerve growth factor (NGF), and its receptors trkA and p75 in ovaries of the cyclic golden hamster (Mesocricetus auratus) and the regulation of their production by luteinizing hormone. J Reprod Dev 50:605-611
47. Heumann R, Lindholm D, Bandtlow C, Meyer M, Radeke MJ, Misko TP, Shooter E, Thoenen H 1987 Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages. Proc Natl Acad Sci USA 84:8735-8739
48. Guazzone VA, Rival C, Denduchis B, Lustig L 2003 Monocyte chemoattractant protein-1 (MCP-1/CCL2) in experimental autoimmune orchitis. J Reprod Immunol 60:143-157
49. Iosub R, Klug J, Fijak M, Schneider E, Frohlich S, Blumbach K, Wennemuth G, Sommerhoff CP, Steinhoff M, Meinhardt A 2006 Development of testicular inflammation in the rat involves activation of proteinase-activated receptor-2. J Pathol 208:686-698
50. Renlund N, Jo Y, Svechnikova I, Holst M, Stocco DM, Soder O, Svechnikov K 2006 Induction of steroidogenesis in immature rat Leydig cells by interleukin-1α is dependent on extracellular signal-regulated kinases. J Mol Endocrinol 36:327-336
51. Petersen C, Svechnikov K, Froysa B, Soder O 2005 The p38 MAPK pathway mediates interleukin-1-induced Sertoli cell proliferation. Cytokine 32:51-59
52. Jegou B, Cudicini C, Gomez E, Stephan JP 1995 Interleukin-1, interleukin-6 and the germ cell-Sertoli cell cross-talk. Reprod Fertil Dev 7:723-730
53. Frungieri MB, Gonzalez-Calvar SI, Parborell F, Albrecht M, Mayerhofer A, Calandra RS 2006 Cyclooxygenase-2 and prostaglandin F2α in Syrian hamster Leydig cells: Inhibitory role on luteinizing hormone/human chorionic gonadotropin-stimulated testosterone production. Endocrinology 147:4476-4485
54. Hubbard AK, Rothlein R 2000 Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades. Free Radic Biol Med 28:1379-1386
55. Yang W, Kaur D, Okayama Y, Ito A, Wardlaw AJ, Brightling CE, Bradding P 2006 Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol 176:1238-1243
56. Brill A, Baram D, Sela U, Salamon P, Mekori YA, Hershkoviz R 2004 Induction of mast cell interactions with blood vessel wall components by direct contact with intact T cells or T cell membranes in vitro. Clin Exp Allergy 34:1725-1731