Hanging-drop multicellular spheroids as a model of tumour angiogenesis

Angiogenesis

Volumn 7, Issue 2, 2004, Pages 97-103

  Timmins, Nicholas ^a   Dietmair, Stefanie ^a   Nielsen, Lars ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

3 D culture; Angiogenesis; Endothelial cell; HUVEC; Multicellular spheroid; Tumour

Indexed keywords

ANGIOGENIC FACTOR;

ANGIOGENESIS; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MICROVASCULATURE; MODEL; MULTICELLULAR SPHEROID; PRIORITY JOURNAL; SOLID TUMOR; TUMOR SPHEROID;

CELL COMMUNICATION; CELL LINE, TUMOR; CELL MOVEMENT; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; SPHEROIDS, CELLULAR; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 8544254739     PISSN: 09696970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10456-004-8911-7     Document Type: Article

References (41)

1. Beecken W, Kramer W, Jonas D et al. New molecular mediators in tumor angiogenesis. J Cell Mol Med 2000; 4(4): 262-269.
2. Gourley M, Williamson J. Angiogenesis: New targets for the development of anticancer chemotherapies. Curr Pharm Des 2000; 6(4): 417-39.
3. Kerbel R. Tumor angiogenesis: Past, present and the near future. Carcinogenesis 2000; 21(3): 505-15.
4. Fidler I. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003; 3(6): 453-8.
5. Fontanini G, Lucchi M, Vignati S et al. Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: A prospective study. J Natl Cancer Inst 1997; 89(12): 881-6.
6. Koomagi R, Volm M. Tissue-factor expression in human non-smallcell lung carcinoma measured by immunohistochemistry: correlation between tissue factor and angiogenesis. Int J Cancer 1998; 79(1): 19-22.
7. Hamada K, Kuratsu J, Saitoh Y. Expression of tissue factor correlates with grade of malignancy in human glioma. Cancer 1996; 77(9): 1877-83.
8. Nakasaki T, Wada H, Shigemori C et al. Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer. Am J Hematol 2002; 69(4): 247-54.
9. Kaku T, Kamura T, Kinukawa N et al. Angiogenesis in endometrial carcinoma. Cancer 1997; 80(4): 741-7.
10. Vermeulen P, Gasparini G, Fox S. Quantification of angiogenesis in solid human tumours: An international consensus on the methodology and criteria of evaluation. Eur J Cancer 1996; 32A(14): 2474-84.
11. Genentech: 2004, 'Avastin (bevacizumab)'. http://www.gene.com/gene/ pipeline/status/oncology/avastin/index.jsp.
12. Sato Y. Molecular diagnosis of tumour angiogenesis and anti-angiogenic cancer therapy. Int J Clin Oncol 2003; 8: 200-6.
13. McCarthy M. Antiangiogenesis drug promising for metastatic colorectal cancer. Lancet 2003; 361(9373): 1959.
14. Auerbach R, Akhtar N, Lewis R, Shinners B. Angiogenesis assays: problems and pitfalls. Cancer Metastasis Rev 2003; 19(1-2) 167-72.
15. Vernon R, Gooden M. New technologies in vitro for analysis of cell movement on or within collagen gels. Matrix Biol 2002; 21(8): 661-9.
16. Vernon R, Sage E. A novel, quantitative model for study of endothelial cell migration and sprout formation within three-dimensional collagen matrices. Microvasc Res 1999; 57(2): 118-33.
17. Donovan D, Brown NJ, Bishop ET, Lewis CE. Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo. Angiogenesis: 2001; 4(2): 113-21.
18. Montaez E, Casaroli-Marano R, Vilar S, Pagan R. Comparative study of tube assembly, in three-dimensional collagne matix and on Matrigel coats. Angiogenesis 2002; 5: 167-72.
19. Auerbach R, Lewis R, Shinners B et al. Angiogenesis assays: A critical overview. Clin Chem 2003; 49 (1): 32-40.
20. Vailhe B, Vittet D, Feige J et al. In vitro models of vasculogenesis and angiogenesis. Lab Invest 2001; 81(4): 439-52.
21. Bishop E, Bell G, Bloor S et al. An in vitro model of angiogenesis: Basic features. Angiogenesis 1999; 3: 335-44.
22. Ment L, Stewart W, Scaramuzzino D, Madri J. An in vitro three-dimensional coculture model of cerebral microvascular angiogenesis and differentiation. In Vitro Cell Dev Biol Anim 1997; 33(9): 684-91.
23. Korff T, Kimmina S, Martiny-Baron G, Augustin HG. Blood vessel maturation in a 3-dimensional spheroidal coculture model: Direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness. FASEB J 2001; 15(2): 447-57.
24. Korff T, Augustin H. Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. J Cell Biol 1998; 143(5): 1341-52.
25. Haspel H, Scicli G, McMahon G, Scicli A. Inhibition of vascular endothelial growth factor-associated tyrosine kinase activity with SU5416 blocks sprouting in the microvascular endothelial cell spheroid model of angiogenesis. Microvasc Res 2002; 63(3): 304-15.
26. Kozien D, Gerol M, Hendey B, RayChaudhury A. A novel in vitro model of tumor angiogenesis. In Vitro Cell Dev Biol Anim 2000; 36(9): 555-8.
27. Oudar O. Spheroids: Relation between tumour and endothelial cells. Crit Rev Oncol Hematol 2000; 36(2-3): 99-106.
28. Chopra V, Dinh TV, Hannigan EV. Three-dimensional endothelial-tumor epithelial cell interactions in human cervical cancers. In Vitro Cell Dev Biol Anim 1997; 33(6): 432-42.
29. Knuchel R, Feichtinger J, Recktenwald A et al. Interactions between bladder tumor cells as tumor spheroids from the cell line J82 and human endothelial cells in vitro. J Urol 1988; 139(3): 640-5.
30. Offner F, Bigalke I, Schiefer J et al. Interaction of human malignant melanoma tumor spheroids with endothelium and reconstituted basement membrane: Modulation by RGDS. Int J Cancer 1993; 54(3): 506-12.
31. Kelm J, Timmins N, Brown C et al. Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol Bioeng 2003; 83(2): 173-80.
32. Wartenberg M, Dnmez F, Ling F et al. Tumour-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells. FASEB J 2001; 15: 995-1005.
33. Shweiki D, Neeman M, Itin A, Keshet E. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis. Proc Natl Acad Sci USA 1995; 92(3): 768-72.
34. Lazareff J, Suwinski R, De Rosa R, Olmstead C. Tumor volume and growth kinetics in hypothalamic-chiasmatic pediatric low grade gliomas. Pediatr Neurosurg 1999; 30(6): 312-9.
35. Marusic M, Bajzer Z, Vuk-Pavlovic, Freyer J. Tumour growth in vivo and as multicellualr spheroids compared by mathematical models. Bull Math Biol 1994; 56: 617-631.
36. Kunz-Schughart L, Mueller-Klieser W. Three-dimensional culture. In. Masters J (ed): Animal Cell Culture: A Practical Approach. New York: Oxford University Press, 3rd edition, 2000; 123-84.
37. Hemmerlein B, Kugler A, Ozisik R et al. Vascular endothelial growth factor expression, angiogenesis, and necrosis in renal cell carcinomas. Virchows Arch 2001; 439(5): 645-52.
38. Guan M, Jin J, Su B et al. Tissue factor expression and angiogenesis in human glioma. Clin Biochem 2002; 35(4): 321-5.
39. Sonoda T, Kobayashi H, Kaku T et al. Expression of angiogenesis factors in monolayer culture, multicellular spheroid and in vivo transplanted tumor by human ovarian cancer cell lines. Cancer Lett 2003; 196(2): 229-37.
40. Burns P, Wilson D. Angiogenesis mediated by metabolites is dependent on vascular endothelial growth factor (VEGF). Angiogenesis 2003; 6(1): 73-7.
41. Pavlakovic H, Havers W, Schweigerer L. Multiple angiogenesis stimulators in a single malignancy: Implications for anti-angiogenic tumour therapy. Angiogenesis 2001; 4(4): 259-62.