Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo

Journal of Investigative Dermatology

Volumn 134, Issue 11, 2014, Pages 2814-2822

  Wu, Xuesong ^a   Schulte, Brian C ^a   Zhou, Youwen ^b   Haribhai, Dipica ^a   Mackinnon, Alexander C ^a   Plaza, Jose A ^a   Williams, Calvin B ^a   Hwang, Sam T ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; CCL1 CHEMOKINE; CD163 ANTIGEN; CD31 ANTIGEN; CLODRONIC ACID; INTERLEUKIN 10; LIPOSOME; MESSENGER RNA; PODOPLANIN; STAT3 PROTEIN; CELL SURFACE RECEPTOR; CYTOKINE; DIFFERENTIATION ANTIGEN; GP38 PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER STAGING; CARCINOGENESIS; CELL SELECTION; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHANGIOGENESIS; M2 LIKE TUMOR ASSOCIATED MACROPHAGE; MACROPHAGE; MACROPHAGE DEPLETION; MOUSE; MYCOSIS FUNGOIDES; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T CELL LYMPHOMA; T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; ANIMAL; BLOOD; BONE MARROW CELL; C57BL MOUSE; CANCER TRANSPLANTATION; CHEMISTRY; CYTOLOGY; DISEASE MODEL; INFLAMMATION; METABOLISM; PATHOLOGY; PHENOTYPE; SCID MOUSE; SKIN TUMOR; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD31; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BONE MARROW CELLS; CELL LINE, TUMOR; CLODRONIC ACID; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; LIPOSOMES; LYMPHOMA, T-CELL, CUTANEOUS; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, SCID; MYCOSIS FUNGOIDES; NEOPLASM TRANSPLANTATION; PHENOTYPE; RECEPTORS, CELL SURFACE; SKIN NEOPLASMS;

EID: 84908607110     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.206     Document Type: Article

References (28)

1. Asai A, Nakamura K, Kobayashi M., et al (2012) CCL1 released from M2b macrophages is essentially required for the maintenance of their properties. J Leukoc Biol 92:859-67
2. Assudulah K, Doecke WD, Haeussler A., et al (1996) Progression of mycosis fungoides is associated with increasing cutaneous expression of interleukin-10 mRNA. J Invest Dermatol 107:833-7
3. Bander NH, Czuczman MS, Younes A (2012) Antibody-drug conjugate technology development for hematologic disorders. Clin Adv Hematol Oncol 10:1-16
4. Bennett CL, van Rijn E, Jung S., et al (2005) Inducible ablation of mouse langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 169:569-76
5. Berger CL, Hanlon D, Kanada D., et al (2002) The growth of cutaneous T-cell lymphoma is stimulated by immature dendritic cells. Blood 99:2929-39
6. Campbell JJ, Clark RA, Watanabe R., et al (2010) Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood 116:767-71
7. Claman HN (1976) Tolerance and contact sensitivity to DNFB in mice. V. induction of tolerance with DNP compounds and with free and membrane-Associated DNFB. J Immunol 116:704-9
8. Fujiwara Y, Komohara Y, Kudo R., et al (2011) Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. Oncol Rep 26:1533-7
9. Geskin L, Kingston A, Whiteside T (2004) An engineered autologous dendritic cell therapy induces potent tumor specific T-cell activity and clinical response in a patient with end-stage cutaneous T-cell lymphoma. J Invest Dermatol 130:A51
10. Girardi M, Berger C, Hanlon D., et al (2002) Efficient tumor antigen loading of dendritic antigen presenting cells by transimmunization. Technol Cancer Res Treat 1:65-9
11. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-74
12. Honeychurch J, Melis MH, Dovedi SJ., et al (2013) Immunogenic potential of irradiated lymphoma cells is enhanced by adjuvant immunotherapy and modulation of local macrophage populations. Leuk Lymphoma 54:2008-15
13. Hwang ST, Janik JE, Jaffe ES., et al (2008) Mycosis fungoides and sezary syndrome. Lancet 371:945-57
14. Kissenpfennig A, Henri S, Dubois B., et al (2005) Dynamics and function of langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating langerhans cells. Immunity 22:643-54
15. Litvinov IV, Jones DA, Sasseville D., et al (2010) Transcriptional profiles predict disease outcome in patients with cutaneous T-cell lymphoma. Clin Cancer Res 16:2106-14
16. Mantovani A, Allavena P, Sica A., et al (2008) Cancer-related inflammation. Nature 454:436-44
17. Mantovani A, Sica A, Sozzani S., et al (2004) The chemokine system in Diverse forms of macrophage activation and polarization. Trends Immunol 25:677-86
18. Martinez FO, Helming L, Gordon S (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 27:451-83
19. Ralfkiaer E, Hou-Jensen K, Mason DY., et al (1985) Benign and malignant lymphocytic skin infiltrates: immunological patterns recognized by immunohistochemical staining with monoclonal antibodies. Adv Exp Med Biol 186:1033-41
20. Rehwald U, Schulz H, Reiser M., et al (2003) Treatment of relapsed CD20θ hodgkin lymphoma with the monoclonal antibody rituximab is effective and well tolerated: results of a phase 2 trial of the german hodgkin lymphoma study grouP Blood 101:420-4
21. Sanchez-Espiridion B, Martin-Moreno AM, Montalban C., et al (2012) Immunohistochemical markers for tumor associated macrophages and survival in advanced classical hodgkin's lymphoma. Haematologica 97:1080-4
22. Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122:787-95
23. Sommer VH, Clemmensen OJ, Nielsen O., et al (2004) In vivo activation of STAT3 in cutaneous T-cell lymphoma. evidence for an antiapoptotic function of STAT3. Leukemia 18:1288-95
24. Steidl C, Lee T, Shah SP., et al (2010) Tumor-Associated macrophages and survival in classic hodgkin's lymphoma. N Engl J Med 362:875-85
25. Sugaya M, Miyagaki T, Ohmatsu H., et al (2012) Association of the numbers of CD163(θ) cells in lesional skin and serum levels of soluble CD163 with disease progression of cutaneous T cell lymphoma. J Dermatol Sci 68: 45-51
26. van Hall T, van Bergen J, van Veelen PA., et al (2000) Identification of a novel tumor-specific CTL epitope presented by RMA, EL-4, and MBL-2 lymphomas reveals their common origin. J Immunol 165:869-77
27. Wu X, Sells RE, Hwang ST (2011) Upregulation of inflammatory cytokines and oncogenic signal pathways preceding tumor formation in a murine model of T-cell lymphoma in skin. J Invest Dermatol 131:1727-34
28. Zhang Y, Wang Y, Yu R., et al (2012) Molecular markers of early-stage mycosis fungoides. J Invest Dermatol 132:1698-1706