Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 5, 2015, Pages 1240-1246.e8

  Park, Heung Woo ^a,c   Ge, Bing ^d   Tse, Szeman ^a,e   Grundberg, Elin ^d   Pastinen, Tomi ^d   Kelly, H William ^f   Tantisira, Kelan G ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Seoul National University College of Medicine   (South Korea)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF MONTREAL   (Canada)

^f UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

Asthma; bone mineral density; child; corticosteroids

Indexed keywords

DEXAMETHASONE; GAMMA TUBULIN; PREDNISONE; CORTICOSTEROID; MICROTUBULE ASSOCIATED PROTEIN; TBCD PROTEIN, HUMAN; TUBG1 PROTEIN, HUMAN; TUBULIN;

ARTICLE; ASTHMA; BONE DENSITY; BONE MINERAL ACCRETION; CHILD; CORTICOSTEROID THERAPY; DISEASE EXACERBATION; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC RISK; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; OSTEOBLAST; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; BONE DEVELOPMENT; BONE DYSPLASIA; BONE MINERALIZATION; CHEMICALLY INDUCED; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; ADRENAL CORTEX HORMONES; ASTHMA; BONE DENSITY; BONE DEVELOPMENT; BONE DISEASES, DEVELOPMENTAL; CALCIFICATION, PHYSIOLOGIC; CHILD; CHILD, PRESCHOOL; DEXAMETHASONE; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; OSTEOBLASTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDNISONE; RISK FACTORS; TUBULIN;

EID: 84929892016     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.04.014     Document Type: Article

References (44)

1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA 285 (2001), 785–795.
2. Kelly, H.W., Van Natta, M.L., Covar, R.A., Tonascia, J., Green, R.P., Strunk, R.C., Effect of long-term corticosteroid use on bone mineral density in children: a prospective longitudinal assessment in the childhood Asthma Management Program (CAMP) study. Pediatrics 122 (2008), e53–e61.
3. Tse, S.M., Kelly, H.W., Litonjua, A.A., Van Natta, M.L., Weiss, S.T., Tantisira, K.G., Corticosteroid use and bone mineral accretion in children with asthma: effect modification by vitamin D. J Allergy Clin Immunol 130 (2012), 53–60.
4. Grundberg, E., Adoue, V., Kwan, T., Ge, B., Duan, Q.L., Lam, K.C., et al. Global analysis of the impact of environmental perturbation on cis-regulation of gene expression. PLoS Genet, 7, 2011, e1001279.
5. Qiu, W., Rogers, A.J., Damask, A., Raby, B.A., Klanderman, B.J., Duan, Q.L., et al. Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis. Hum Mol Genet 23 (2014), 5017–5024.
6. Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med 343 (2000), 1054–1063.
7. Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A., Bender, D., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81 (2007), 559–575.
8. Marchini, J., Howie, B., Genotype imputation for genome-wide association studies. Nat Rev Genet 11 (2010), 499–511.
9. Gauderman WJ, Morrison JM. Quanto 1.2.4: a computer program for power and sample size calculations for genetic-epidemiology studies. Available at: http://biostats.usc.edu/Quanto.html. Accessed December 26, 2014.
10. Kraft, P., Yen, Y.C., Stram, D.O., Morrison, J., Gauderman, W.J., Exploiting gene-environment interaction to detect genetic associations. Hum Hered 63 (2007), 111–119.
11. Kaufman, J.M., Ostertag, A., Saint-Pierre, A., Cohen-Solal, M., Boland, A., Van Pottelbergh, I., et al. Genome-wide linkage screen of bone mineral density (BMD) in European pedigrees ascertained through a male relative with low BMD values: evidence for quantitative trait loci on 17q21-23, 11q12-13, 13q12-14, and 22q11. J Clin Endocrinol Metab 93 (2008), 3755–3762.
12. Cunningham, L.A., Kahn, R.A., Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle. J Biol Chem 283 (2008), 7155–7165.
13. The Global Initiative for Asthma (GINA). The guideline for asthma management and prevention 2010. Available at: http://www.ginasthma.org/guidelines-pocket-guide-for-asthma-management.html. Accessed May 18, 2014.
14. The National Asthma Education and Prevention Program (NAEPP). National Asthma Education and Prevention Program Expert Panel Report 3: guidelines for the diagnosis and management of asthma 2007. Available at: http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.pdf. Accessed May 18, 2014.
15. British Thoracic Society, Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Available at: http://www.sign.ac.uk/pdf/sign101.pdf. Accessed May 18, 2014.
16. Potter, P.C., Current guidelines for the management of asthma in young children. Allergy Asthma Immunol Res 2 (2010), 1–13.
17. Brown, J.J., Zacharin, M.R., Proposals for prevention and management of steroid induced osteoporosis in children and adolescents. J Paediatr Child Health 41 (2005), 553–557.
18. Lee, P.H., Shatkay, H., F-SNP: computationally predicted functional SNPs for disease association studies. Nucleic Acids Res 36 (2008), D820–D824.
19. Lee, P.H., Shatkay, H., An integrative scoring system for ranking SNPs by their potential deleterious effects. Bioinformatics 25 (2009), 1048–1055.
20. Clarke, B., Normal bone anatomy and physiology. Clin J Am Soc Nephrol 3:suppl 3 (2008), S131–S139.
21. Canalis, E., Bilezikian, J.P., Angeli, A., Giustina, A., Perspectives on glucocorticoid-induced osteoporosis. Bone 34 (2004), 593–598.
22. Pereira, R.C., Delany, A.M., Canalis, E., Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. Bone 30 (2002), 685–691.
23. Weinstein, R.S., Jilka, R.L., Parfitt, A.M., Manolagas, S.C., Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids: potential mechanisms of their deleterious effects on bone. J Clin Invest 102 (1998), 274–282.
24. Delany, A.M., Gabbitas, B.Y., Canalis, E., Cortisol downregulates osteoblast alpha 1 (I) procollagen mRNA by transcriptional and posttranscriptional mechanisms. J Cell Biochem 57 (1995), 488–494.
25. Gundersen, G.G., Cook, T.A., Microtubules and signal transduction. Curr Opin Cell Biol 11 (1999), 81–94.
26. Jordan, M.A., Wilson, L., Microtubules as a target for anticancer drugs. Nat Rev Cancer 4 (2004), 253–265.
27. Zhao, M., Ko, S.Y., Liu, J.H., Chen, D., Zhang, J., Wang, B., et al. Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol Cell Biol 29 (2009), 1291–1305.
28. Zou, W., Greenblatt, M.B., Brady, N., Lotinun, S., Zhai, B., de Rivera, H., et al. The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. J Exp Med 210 (2013), 1793–1806.
29. Moudjou, M., Bordes, N., Paintrand, M., Bornens, M., gamma-Tubulin in mammalian cells: the centrosomal and the cytosolic forms. J Cell Sci 109 (1996), 875–887.
30. Raynaud-Messina, B., Merdes, A., Gamma-tubulin complexes and microtubule organization. Curr Opin Cell Biol 19 (2007), 24–30.
31. Tian, G., Huang, Y., Rommelaere, H., Vandekerckhove, J., Ampe, C., Cowan, N.J., Pathway leading to correctly folded beta-tubulin. Cell 86 (1996), 287–296.
32. Colello, D., Reverte, C.G., Ward, R., Jones, C.W., Magidson, V., Khodjakov, A., et al. Androgen and Src signaling regulate centrosome activity. J Cell Sci 123 (2010), 2094–2102.
33. Murakami, K., Fellous, A., Baulieu, E.E., Robel, P., Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly. Proc Natl Acad Sci U S A 97 (2000), 3579–3584.
34. Dahlin, A., Tantisira, K.G., Integrative systems biology approaches in asthma pharmacogenomics. Pharmacogenomics 13 (2012), 1387–1404.
35. Fairfax, B.P., Makino, S., Radhakrishnan, J., Plant, K., Leslie, S., Dilthey, A., et al. Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat Genet 44 (2012), 502–510.
36. Zoorob, R.J., Cender, D., A different look at corticosteroids. Am Fam Physician 58 (1998), 443–450.
37. Greenberg, R.A., Kerby, G., Roosevelt, G.E., A comparison of oral dexamethasone with oral prednisone in pediatric asthma exacerbations treated in the emergency department. Clin Pediatr 47 (2008), 817–823.
38. Shefrin, A.E., Goldman, R.D., Use of dexamethasone and prednisone in acute asthma exacerbations in pediatric patients. Can Fam Physician 55 (2009), 704–706.
39. The SCAN database. Available at: http://www.scandb.org/newinterface/about.html. Accessed May 18, 2014.
40. Gamazon, E.R., Zhang, W., Konkashbaev, A., Duan, S., Kistner, E.O., Nicolae, D.L., et al. SCAN: SNP and copy number annotation. Bioinformatics 26 (2010), 259–262.
41. Chan, W.H., Wu, H.J., Shiao, N.H., Apoptotic signaling in methylglyoxal-treated human osteoblasts involves oxidative stress, c-Jun N-terminal kinase, caspase-3, and p21-activated kinase 2. J Cell Biochem 100 (2007), 1056–1069.
42. Huang, Y.T., Lai, C.Y., Lou, S.L., Yeh, J.M., Chan, W.H., Activation of JNK and PAK2 is essential for citrinin-induced apoptosis in a human osteoblast cell line. Environ Toxicol 24 (2009), 343–356.
43. Deepa, S.S., Dong, L.Q., APPL1: role in adiponectin signaling and beyond. Am J Physiol Endocrinol Metab 296 (2009), E22–E36.
44. Tu, Q., Zhang, J., Dong, L.Q., Saunders, E., Luo, E., Tang, J., et al. Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1. J Biol Chem 286 (2011), 12542–12553.