Tetramethylpyrazine ameliorated hypoxia-induced myocardial cell apoptosis via HIF-1α/JNK/p38 and IGFBP3/BNIP3 inhibition to upregulate PI3K/Akt survival signaling

Cellular Physiology and Biochemistry

Volumn 36, Issue 1, 2015, Pages 334-344

  Lin, Kuan Ho ^a,b,c   Kuo, Wei Wen ^a   Jiang, Ai Zhi ^a   Pai, Peiying ^c   Lin, Jing Ying ^d   Chen, Wei Kung ^a,b   Day, Cecilia Hsuan ^e   Shen, Chia Yao ^e   Padma, V Vijaya ^f   Huang, Chih Yang ^a,g  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e MEIHO UNIVERSITY   (Taiwan)

^f BHARATHIAR UNIVERSITY   (India)

^g ASIA UNIVERSITY   (Taiwan)

Author keywords

Cardiomyocyte; H9c2; Hemorrhagic shock; Hypoxia; IGF 1 survival pathway; Tetramethylpyrazine

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 9; CYTOCHROME C; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAK; PROTEIN BNIP3; PROTEIN KINASE B; SMALL INTERFERING RNA; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TETRAMETHYLPYRAZINE; PYRAZINE DERIVATIVE;

ANIMAL CELL; ANTIAPOPTOTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; HEART MUSCLE CELL; HEART PROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; MYOBLAST;

LIGUSTICUM SINENSE; LIGUSTICUM WALLICHII; RATTUS;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; GENE EXPRESSION REGULATION; MYOBLASTS, CARDIAC; MYOCYTES, CARDIAC; PYRAZINES; RATS; SIGNAL TRANSDUCTION;

EID: 84929869786     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000374076     Document Type: Article

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