Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: The role of class I P110 isoforms

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Conte, Enrico ^a   Fruciano, Mary ^a   Fagone, Evelina ^a   Gili, Elisa ^a   Caraci, Filippo ^a   Iemmolo, Maria ^a   Crimi, Nunzio ^a   Vancheri, Carlo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE P110ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE P110BETA; PHOSPHATIDYLINOSITOL 3 KINASE P110DELTA; PHOSPHATIDYLINOSITOL 3 KINASE P110GAMMA; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; MORPHOLINE DERIVATIVE; PROTEIN KINASE INHIBITOR;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; EX VIVO STUDY; FIBROSING ALVEOLITIS; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MITOSIS INHIBITION; MYOFIBROBLAST; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; LUNG; METABOLISM;

CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMONES; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; HUMANS; ISOENZYMES; LUNG; MORPHOLINES; MYOFIBROBLASTS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; TRANSFORMING GROWTH FACTOR BETA;

EID: 80053452377     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024663     Document Type: Article

References (23)

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