T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines

Journal of Experimental and Clinical Cancer Research

Volumn 34, Issue 1, 2015, Pages

  Huang, Weifeng ^a   Lu, Chunjing ^b   Wu, Yong ^a   Ouyang, Shou ^c   Chen, Yuanzhong ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b Maternal and Child Health Hospital of Xiamen   (China)

^c Xiamen Institute of Medicine   (China)

Author keywords

Apoptosis; Leukemia; Mibefradil; NNC 55 0396; Proliferation; T type calcium channels

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; MIBEFRADIL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NNC 55 0396; UNCLASSIFIED DRUG; (1S,2S)-2-(2-(N-((3-BENZIMIDAZOL-2-YL)PROPYL)-N-METHYLAMINO)ETHYL)-6-FLUORO-1,2,3,4-TETRAHYDRO-1-ISOPROPYL-2-NAPHTYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE; BENZIMIDAZOLE DERIVATIVE; CYCLOPROPANE DERIVATIVE; NAPHTHALENE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CANCER INHIBITION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MALE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; GENETICS; LEUKEMIA; METABOLISM; MONONUCLEAR CELL; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; BENZIMIDAZOLES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLOPROPANES; ENDOPLASMIC RETICULUM; HUMANS; LEUKEMIA; LEUKOCYTES, MONONUCLEAR; MAP KINASE SIGNALING SYSTEM; MIBEFRADIL; NAPHTHALENES;

EID: 84929815874     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/s13046-015-0171-4     Document Type: Article

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