Activated K-Ras, but Not H-Ras or N-Ras, regulates brain neural stem cell proliferation in a Raf/Rb-dependent manner

Stem Cells

Volumn 33, Issue 6, 2015, Pages 1998-2010

  Bender, R Hugh F ^a   Haigis, Kevin M ^b   Gutmann, David H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cell proliferation; Neural stem cells; Raf kinases; Ras proteins; Retinoblastoma protein

Indexed keywords

H RAS PROTEIN; K RAS PROTEIN; N RAS PROTEIN; RAF PROTEIN; RAS PROTEIN; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CELL; BRAIN TISSUE; CELL GROWTH; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENETICALLY ENGINEERED MOUSE STRAIN; IN VITRO STUDY; IN VIVO STUDY; MAMMAL; MOLECULE; MOUSE; NEURAL STEM CELL; NONHUMAN; PROTEIN BINDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; WILD TYPE; ANIMAL; CELL CYCLE; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; METABOLISM; PHYSIOLOGY;

MAMMALIA;

ANIMALS; BRAIN; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; MICE; NEURAL STEM CELLS; RAS PROTEINS; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION;

EID: 84929783046     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1990     Document Type: Article

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