Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy

Science Translational Medicine

Volumn 7, Issue 288, 2015, Pages

  Doody, Karen M ^a   Stanford, Stephanie M ^a   Sacchetti, Cristiano ^a   Svensson, Mattias N D ^a   Coles, Charlotte H ^b,l   Mitakidis, Nikolaos ^b   Kiosses, William B ^c   Bartok, Beatrix ^d   Fos, Camille ^a   Cory, Esther ^e   Sah, Robert L ^e   Liu Bryan, Ru ^d,f   Boyle, David L ^d   Arnett, Heather A ^g   Mustelin, Tomas ^h   Corr, Maripat ^d   Esko, Jeffrey D ⁱ   Tremblay, Michel L ^j,k   Firestein, Gary S ^d   Aricescu, A Radu ^b   Bottini, Nunzio ^a   more..

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^g AMGEN INC   (United States)

^h MEDIMMUNE   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j MCGILL UNIVERSITY   (Canada)

^k MCGILL UNIVERSITY   (Canada)

^l GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

EZRIN; PHOSPHATASE; SYNDECAN 4; ANTIRHEUMATIC AGENT; CYTOSKELETON PROTEIN; HEPARIN; HEPARIN PROTEOGLYCAN; PROTEOCHONDROITIN SULFATE; PROTEOGLYCAN; PTPRS PROTEIN, HUMAN; PTPRS PROTEIN, MOUSE; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; SDC4 PROTEIN, HUMAN; SDC4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE CONTROL; DISEASE SEVERITY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; PROTEOGLYCAN SWITCH; RHEUMATOID ARTHRITIS; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, RHEUMATOID; CELL MOTION; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PHOSPHORYLATION; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; SYNOVIUM; TIME FACTOR;

ANIMALS; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CELL ADHESION; CELL MOVEMENT; CHONDROITIN SULFATE PROTEOGLYCANS; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; HEK293 CELLS; HEPARIN; HUMANS; MICE, KNOCKOUT; MOLECULAR TARGETED THERAPY; PHOSPHORYLATION; PROTEOGLYCANS; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 2; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; SYNDECAN-4; SYNOVIAL MEMBRANE; TIME FACTORS; TRANSFECTION;

EID: 84929773737     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aaa4616     Document Type: Article

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