Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 31, 2014, Pages 11419-11424

  Stangenberg, Lars ^a,b   Burzyn, Dalia ^b   Binstadt, Bryce A ^b,c   Weissleder, Ralph ^a   Mahmood, Umar ^a   Benoist, Christophe ^b   Mathis, Diane ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Autoantibody; Inflammation; Nervous system; Vascular system

Indexed keywords

AUTOANTIBODY; CHOLINERGIC RECEPTOR; GUANETHIDINE; INTERLEUKIN 1; INTERLEUKIN 6; NORADRENALIN; NORADRENALIN UPTAKE INHIBITOR; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; ASTROCYTE; BLOOD VESSEL PERMEABILITY; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CRUSH TRAUMA; DENERVATION; ENDOTHELIUM CELL; FEMORAL NERVE; HEMIPLEGIA; MALE; MICROVASCULATURE; MOTOR PERFORMANCE; MOUSE; NERVE ENDING; NERVE TRANSECTION; NONHUMAN; PERICYTE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SCIATIC NERVE; SYMPATHECTOMY; TIGHT JUNCTION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION;

AUTOANTIBODY; INFLAMMATION; NERVOUS SYSTEM; VASCULAR SYSTEM;

ANIMALS; ANKLE; ARTHRITIS, EXPERIMENTAL; DENERVATION; DISEASE MODELS, ANIMAL; HINDLIMB; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MICROVESSELS; PARALYSIS; SERUM; TRANSCRIPTOME;

EID: 84905671112     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1410854111     Document Type: Article

References (36)

1. Eskandari F, Webster JI, Sternberg EM (2003) Neural immune pathways and their connection to inflammatory diseases. Arthritis Res Ther 5(6):251-265. (Pubitemid 37407974)
2. Kass EH, Finland M (1951) The role of adrenal steroids in infection and immunity. N Engl J Med 244(13):464-470.
3. Levine JD, Coderre TJ, Helms C, Basbaum AI (1988) Beta 2-adrenergic mechanisms in experimental arthritis. Proc Natl Acad Sci USA 85(12):4553-4556.
4. Alawi K, Keeble J (2010) The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation. Pharmacol Ther 125(2):181-195.
5. Borovikova LV, et al. (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405(6785):458-462. (Pubitemid 30367422)
6. Coste F, Forestier M (1935) Hemiplegie et nodosities d'Heberden contralaterales. Bull Mem Soc Med Hop Paris 51:772-776.
7. Jacqueline F (1953) [A case of evolutive polyarthritis with localisation controlateral to a hemiplegia]. Rev Rhum Mal Osteoartic 20(4):323-324.
8. Thompson M, Bywaters EG (1962) Unilateral rheumatoid arthritis following hemiplegia. Ann Rheum Dis 21:370-377.
9. Kouskoff V, et al. (1996) Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-822. (Pubitemid 26404281)
10. Monach PA, Mathis D, Benoist C (2008) The K/BxN arthritis model. Curr Protoc Immunol Chapter 15 Unit 15.22.
11. Ji H, et al. (2002) Arthritis critically dependent on innate immune system players. Immunity 16(2):157-168. (Pubitemid 34211957)
12. Nigrovic PA, et al. (2007) Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci USA 104(7):2325-2330. (Pubitemid 46391396)
13. Zhang N, Ahsan MH, Purchio AF, West DB (2005) Serum amyloid A-luciferase transgenic mice: Response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition. J Immunol 174(12):8125-8134. (Pubitemid 40806324)
14. Pongratz G, Straub RH (2013) Role of peripheral nerve fibres in acute and chronic inflammation in arthritis. Nat Rev Rheumatol 9(2):117-126.
15. Härle P, Möbius D, Carr DJ, Schölmerich J, Straub RH (2005) An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis. Arthritis Rheum 52(4):1305-1313. (Pubitemid 40530141)
16. Wang H, et al. (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421(6921):384-388. (Pubitemid 36157937)
17. Carolan EJ, Casale TB (1993) Effects of neuropeptides on neutrophil migration through noncellular and endothelial barriers. J Allergy Clin Immunol 92(4):589-598. (Pubitemid 23317084)
18. Saban MR, Saban R, Bjorling D, Haak-Frendscho M (1997) Involvement of leukotrienes, TNF-alpha, and the LFA-1/ICAM-1 interaction in substance P-induced granulocyte infiltration. J Leukoc Biol 61(4):445-451. (Pubitemid 27219838)
19. Binstadt BA, et al. (2006) Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-292.
20. Ruiz de Almodovar C, et al. (2011) VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron 70(5):966-978.
21. Zlokovic BV (2011) Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 12(12):723-738.
22. Sachithanandan N, et al. (2011) Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance. Diabetes 60(8):2023-2031.
23. Nava P (1953) [Old rheumatoid arthritis; cerebral ictus; acute evolutive outbreak of pain in joints of the hemiplegic side]. Bras Med 67(16-17):318-321.
24. Luo L, O'Leary DD (2005) Axon retraction and degeneration in development and disease. Annu Rev Neurosci 28:127-156. (Pubitemid 41098902)
25. Mueller M, et al. (2003) Macrophage response to peripheral nerve injury: The quantitative contribution of resident and hematogenousmacrophages. Lab Invest 83(2):175-185. (Pubitemid 36255363)
26. Perrin FE, Lacroix S, Avilés-Trigueros M, David S (2005) Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration. Brain 128(Pt 4):854-866. (Pubitemid 40516922)
27. Shamash S, Reichert F, Rotshenker S (2002) The cytokine network of Wallerian degeneration: Tumor necrosis factor-alpha, interleukin-1alpha, and interleukin-1beta. J Neurosci 22(8):3052-3060. (Pubitemid 35379194)
28. Wipke BT, Wang Z, Kim J, McCarthy TJ, Allen PM (2002) Dynamic visualization of a joint-specific autoimmune response through positron emission tomography. Nat Immunol 3(4):366-372. (Pubitemid 34308625)
29. Ruan GX, Kazlauskas A (2012) Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J 31(7):1692-1703.
30. Ludwig RJ, et al. (2005) Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation. J Invest Dermatol 125(5):969-976.
31. Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (2002) Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Blood 100(7):2479-2486.
32. Galaup A, et al. (2006) Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. Proc Natl Acad Sci USA 103(49):18721-18726. (Pubitemid 44913477)
33. Galaup A, et al. (2012) Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4. Circulation 125(1):140-149.
34. Löbel M, et al. (2012) CCN1: A novel inflammation-regulated biphasic immune cell migration modulator. Cell Mol Life Sci 69(18):3101-3113.
35. Jacobs JP, et al. (2010) Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model. Arthritis Rheum 62(7):1921-1932.
36. Burzyn D, et al. (2013) A special population of regulatory T cells potentiates muscle repair. Cell 155(6):1282-1295.