Integrating complementary medicine in cancer supportive care across the middle east: Challenges and opportunities

Palliative Care to the Cancer Patient: The Middle East as a Model for Emerging Countries

Volumn , Issue , 2014, Pages 77-97

  Ben Arye, Eran ^a,b  

^a CLALIT HEALTH SERVICES   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84929711946     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (181)

1. Deng GE, Cassileth BR, Cohen L, Gubili J, Johnstone PA, Kumar N, Vickers A; Society for Integrative Oncology Executive Committee, Abrams D, Rosenthal D, Sagar S, Tripathy D. Integrative Oncology Practice Guidelines. J. Soc. Integr. Oncol. 2007;5(2):65-84.
2. Frenkel M, Cohen L, Peterson N, et al: Integrative medicine consultation service in a comprehensive cancer center: findings and outcomes. Integr. Cancer Ther. 2010;9(3):276-83.
3. Deng G: Integrative Cancer Care in a US Academic Cancer Centre: The Memorial Sloan-Kettering Experience. Curr. Oncol. Suppl. 2008;2:s108.es68-71.
4. Ben-Arye E, Schiff E, Zollman C, Heusser P, Mountford P, Frenkel M, Bar-Sela G, Lavie O. Integrating complementary medicine in supportive cancer care models across four continents. Med. Oncol. 2013;30(2):511.
5. Ben-Arye E, Schiff E, Shapira C, Frenkel M, Shalom T, Steiner M. Modeling an integrative oncology program within a community-centered oncology service in Israel. Patient Educ. Couns. 2012;89(3):423-9.
6. Ben-Arye E, Attias S, Tadmor T, Schiff E. Herbs in hemato-oncological care: an evidence-based review of data on efficacy, safety, and drug interactions. Leuk Lymphoma. 2010;51(8):1414-23.
7. Al-Omari A, Al-Qudimat M, Abu Hmaidan A, Zaru L. Perception and attitude of Jordanian physicians towards complementary and alternative medicine (CAM) use in oncology. Complement Ther. Clin. Pract. 2013;19(2):70-6.
8. Montazeri A, Sajadian A, Ebrahimi M, Haghighat S, Harirchi I (2007) Factors predicting the use of complementary and alternative therapies among cancer patients in Iran. Eur. J. Cancer Care (Engl). 16(2):144-149.
9. Brahmi SA, El M'rabet FZ, Benbrahim Z, Akesbi Y, Amine B, Nejjari C, El Mesbahi O. Complementary medicine use among Moroccan patients with cancer: a descriptive study 4Pan Afr. Med. J. 2011;10:36.
10. Paltiel O, Avitzour M, Peretz T, Cherny N, Kaduri L, Pfeffer RM, Wagner N, Soskolne V. Determinants of the use of complementary therapies by patients with cancer. J. Clin. Oncol. 2001 ;19(9):2439-48.
11. Yildiz I, Ozguroglu M, Toptas T, Turna H, Sen F, Yildiz M. Patterns of complementary and alternative medicine use among Turkish cancer patients. J. Palliat. Med. 2013;16(4):383-90.
12. Jazieh AR, Al Sudairy R, Abulkhair O, Alaskar A, Al Safi F, Sheblaq N, Young S, Issa M, Tamim H. Use of complementary and alternative medicine by patients with cancer in Saudi Arabia. J. Altern Complement Med. 2012;18(11):1045-9.
13. Akhu-Zaheya LM, Alkhasawneh EM. Complementary alternative medicine use among a sample of Muslim Jordanian oncology patients. Complement Ther. Clin. Pract. 2012;18(2):121-6.
14. Inanç N, Sahin H, Ciçek B, Taşc S. Use of herbs or vitamin/mineral supplements by patients with cancer in Kayseri, Turkey. Cancer Nurs. 2006;29(1):17-20.
15. Afifi FU, Wazaify M, Jabr M, Treish E. The use of herbal preparations as complementary and alternative medicine (CAM) in a sample of patients with cancer in Jordan. Complement Ther. Clin. Pract. 2010;16(4):208-12.
16. Ali-Shtayeh MS, Jamous RM, Jamous RM. Herbal preparation use by patients suffering from cancer in Palestine. Complement Ther. Clin. Pract. 2011;17(4):235-40. doi: 10.1016/j.ctcp.2011.06.002.
17. Yildirim Y. Patterns of the use of complementary and alternative medicine in women with metastatic cancer. Cancer Nurs. 2010;33(3):194-200.
18. Akyol AD, Oz B. The use of complementary and alternative medicine by patients with cancer: in Turkey. Complement Ther. Clin. Pract. 2011;17(4):230-4.
19. Malak AT, Karayurt ZL, Demir E, Y Mer AS. Complementary and alternative medicine in cancer patients - analysis of influencing factors in Turkey. Asian Pac. J. Cancer Prev. 2009;10(6):1083-7.
20. Can G, Erol O, Aydiner A, Topuz E. Quality of life and complementary and alternative medicine use among cancer patients in Turkey. Eur. J. Oncol. Nurs. 2009;13(4):287-94.
21. Özcelik, H, Fadiloglu. [Reasons for use of complementary and alternative medicine in cancer patients]. Türk Onkoloji Dergisi, 2009;24(1):48-52.
22. Yazar Adı: Ucan O, Pehlivan S, Ovayolu N, Sevinc A, Camci C. The use of complementary therapies in cancer patients: a questionnaire-based descriptive survey from southeastern Turkey. Am. J. Clin. Oncol. 2008;31(6):589-94.
23. Er O, Mistik S, Ozkan M, Ozturk A, Altinbas M. Factors related to complementary/alternative medicine use among cancer patients in central Anatolia. Tumori. 2008;94(6):833-7.
24. Yildirim Y, Tinar S, Yorgun S, Toz E, Kaya B, Sonmez S, Balsak D. The use of complementary and alternative medicine (CAM) therapies by Turkish women with gynecological cancer. Eur. J. Gynaecol. Oncol. 2006;27(1):81-5.
25. Yildiz I, Ozguroglu M, Toptas T, Turna H, Sen F, Yildiz M. Patterns of complementary and alternative medicine use among Turkish cancer patients. J. Palliat Med. 2013;16(4):383-90.
26. Genc RE, Senol S, Turgay AS, Kantar M. Complementary and alternative medicine used by pediatric patients with cancer in western Turkey. Oncol. Nurs Forum. 2009;36(3):E159-64.
27. Karalı Y, Demirkaya M, Sevinir B. Use of complementary and alternative medicine in children with cancer: effect on survival. Pediatr Hematol Oncol. 2012;29(4):335-44.
28. Nazik E, Nazik H, Api M, Kale A, Aksu M. Complementary and alternative medicine use by gynecologic oncology patients in Turkey. Asian Pac. J. Cancer Prev. 2012;13(1):21-5.
29. Tarhan O, Alacacioglu A, Somali I, Sipahi H, Zencir M, Oztop I, Dirioz M, Yilmaz U. Complementary-alternative medicine among cancer patients in the western region of Turkey. J. BUON. 2009;14(2):265-9.
30. Aksu MG, Bozcuk HS, Korcum AF. Effect of complementary and alternative medicine during radiotherapy on radiation toxicity. Support Care Cancer. 2008 ;16(4):415-9.
31. Inanç N, Sahin H, Ciçek B, Taşc S. Use of herbs or vitamin/mineral supplements by patients with cancer in Kayseri, Turkey. Cancer Nurs. 2006;29(1):17-20.
32. Ulger O, Yağli NV. Effects of yoga on the quality of life in cancer patients. Complement Ther. Clin. Pract. 2010;16(2):60-3.
33. Aktas G, Ogce F. Dance as a therapy for cancer prevention. Asian Pac. J. Cancer Prev. 2005;6(3):408-11.
34. Yildirim Y. Patterns of the use of complementary and alternative medicine in women with metastatic cancer. Cancer Nurs. 2010;33(3):194-200.
35. Akyuz A, Dede M, Cetinturk A, Yavan T, Yenen MC, Sarici SU, Dilek S. Selfapplication of complementary and alternative medicine by patients with gynecologic cancer. Gynecol. Obstet. Invest. 2007;64(2):75-81.
36. Unyayar A, Demirbilek M, Turkoglu M, Celik A, Mazmanci MA, Erkurt EA, Unyayar S, Cekic O, Atacag H. Evaluation of cytotoxic and mutagenic effects of Coriolus versicolor and Funalia trogii extracts on mammalian cells. Drug Chem. Toxicol. 2006;29(1):69-83.
37. Ozmen A, Bauer S, Gridling M, Singhuber J, Krasteva S, Madlener S, Vo TP, Stark N, Saiko P, Fritzer-Szekeres M, Szekeres T, Askin-Celik T, Krenn L, Krupitza G. In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey. Oncol. Rep. 2009;22(4):845-52.
38. Turan N, Akgün-Dar K, Kuruca SE, Kiliçaslan-Ayna T, Seyhan VG, Atasever B, Meriçli F, Carin M. Cytotoxic effects of leaf, stem and root extracts of Nerium oleander on leukemia cell lines and role of the p-glycoprotein in this effect. J. Exp. Ther. Oncol. 2006;6(1):31-8.
39. Ozmen A, Madlener S, Bauer S, Krasteva S, Vonach C, Giessrigl B, Gridling M, Viola K, Stark N, Saiko P, Michel B, Fritzer-Szekeres M, Szekeres T, Askin-Celik T, Krenn L, Krupitza G. In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey. Phytomedicine. 2010;17(1):55-62.
40. Taşkin EI, Akgün-Dar K, Kapucu A, Osanç E, Doğruman H, Eraltan H, Ulukaya E. Apoptosis-inducing effects of Morinda citrifolia L. and doxorubicin on the Ehrlich ascites tumor in Balb-c mice. Cell Biochem. Funct. 2009;27(8):542-6.
41. Yazici ZM, Meric A, Midi A, Arınc YV, Kahya V, Hafız G. Reduction of cisplatin ototoxicity in rats by oral administration of pomegranate extract. Eur. Arch. Otorhinolaryngol. 2012;269(1):45-52.
42. Genç A, Can G, Aydiner A. The efficiency of the acupressure in prevention of the chemotherapy-induced nausea and vomiting. Support Care Cancer. 2013;21(1):253-61.
43. Taspinar A, Sirin A. Effect of acupressure on chemotherapy-induced nausea and vomiting in gynecologic cancer patients in Turkey. Eur. J. Oncol. Nurs. 2010;14(1):49-5.
44. Genç A, Ikiz AO, Güneri EA, Günerli A. Effect of deep breathing exercises on oxygenation after major head and neck surgery. Otolaryngol Head Neck Surg. 2008;139(2):281-5.
45. Demiralp M, Oflaz F, Komurcu S. Effects of relaxation training on sleep quality and fatigue in patients with breast cancer undergoing adjuvant chemotherapy. J. Clin. Nurs. 2010;19(7-8):1073-83.
46. Ulger O, Yağli NV. Effects of yoga on the quality of life in cancer patients. Complement Ther. Clin. Pract. 2010;16(2):60-3.
47. Yucel I, Guzin G. Topical henna for capecitabine induced hand-foot syndrome. Invest New Drugs. 2008;26(2):189-92.
48. Can G, Topuz E, Derin D, Durna Z, Aydiner A. Effect of kefir on the quality of life of patients being treated for colorectal cancer. Oncol. Nurs Forum. 2009;36(6):E335-42.
49. Aksu MG, Bozcuk HS, Korcum AF. Effect of complementary and alternative medicine during radiotherapy on radiation toxicity. Support Care Cancer. 2008;16(4):415-9.
50. Pud D, Kaner E, Morag A, Ben-Ami S, Yaffe A. Use of complementary and alternative medicine among cancer patients in Israel. Eur. J. Oncol Nurs. 2005;9(2):124-30.
51. Ben-Arye E, Steinmetz D, Ezzo J. Two women and cancer - The need for addressing spiritual well-being in cancer care. Families Systems and Health. 2007;25(1):1-9.
52. Frenkel M, Ben-Arye E, Baldwin CD, Sierpina V. An Approach to Communicating with Patients about the Use of Nutritional Supplements in Cancer Care. Southern Medical Journal. 2005; 98(3):289-294.
53. Ben-Arye E, Frenkel M. [ Doctor, patient and cancer in the encounter of complementary and conventional medicine]. The Israel Journal of Family Practice. 2004; 14(114-115): 11-17.
54. Popper-Giveon A, Schiff E, Ben-Arye E. I will always be with you: traditional and complementary therapists' perspectives on patient-therapist-doctor communication regarding treatment of Arab patients with cancer in Israel. Patient Educ. Couns. 2012;89(3):381-6.
55. Barak F, Lugacy G, Kreitler S. Complementary medicine regulations. Patient Educ. Couns. 2008;73(1):166-7.
56. Ben-Arye E, Schiff E, Golan O. Ethical issues in integrative oncology. Hematology/Oncology Clinics of North America. 2008;22(4):737-53.
57. Ben-Arye E, Schiff E, Steiner M, Keshet Y, Lavie O. Attitudes of patients with gynecological and breast cancer toward integration of complementary medicine in cancer care. Int. J. Gynecol Cancer. 2012;22(1):146-5.
58. Weyl Ben Arush M, Geva H, Ofir R, Mashiach T, Uziel R, Dashkovsky Z. Prevalence and characteristics of complementary medicine used by pediatric cancer patients in a mixed western and middle-eastern population. J. Pediatr Hematol. Oncol. 2006;28(3):141-6.
59. Paltiel O, Avitzour M, Peretz T, Cherny N, Kaduri L, Pfeffer RM, Wagner N, Soskolne V. Determinants of the use of complementary therapies by patients with cancer. J. Clin. Oncol. 2001;19(9):2439-48.
60. Talmi YP, Yakirevitch A, Migirov L, Horowitz Z, Bedrin L, Simon Z, Pfeffer MR. Limited use of complementary and alternative medicine in Israeli head and neck cancer patients. Laryngoscope. 2005;115(8):1505-8.
61. Ben-Arye E, Bar-Sela G, Frenkel M, Kuten A, Hermoni D. Is a bio-psycho-socialspiritual approach relevant to cancer treatment? A study of patients and oncology staff members on issues of complementary medicine and spirituality. Supportive Care in Cancer. 2006; 14(2):147-52.
62. Ben-Arye E, Attias S, Tadmor T, Schiff E. Herbs in hemato-oncological care: an evidence-based review of data on efficacy, safety, and drug interactions. Leuk Lymphoma. 2010;51(8):1414-23.
63. Zaid H, Rayan A, Said O, Saad B. Cancer Treatment by Greco-Arab and Islamic Herbal Medicine. The Open Nutraceuticals Journal, 2010; 3.
64. Popper-Giveon A, Schiff E, Ben-Arye E. We and They in the House of Healing:Debate Among Arab Complementary Medicine Practitioners on an Integrative Versus Alternative Approach to Supportive Cancer Care. Integr. Cancer Ther. 2013 Apr 26.
65. Samuels N. [Acupuncture for cancer patients: why not?] Harefuah. 2002;141(7):608-10, 666.
66. Baider L, Uziely B, De-Nour AK. Progressive muscle relaxation and guided imagery in cancer patients. Gen. Hosp. Psychiatry. 1994;16(5):340-7.
67. Ben-Arye E, Schiff E, Vintal H, Agour O, Preis L, Steiner M. Integrating complementary medicine and supportive care: patients' perspectives toward complementary medicine and spirituality. J. Altern Complement Med. 2012;18(9):824-3.
68. Bar-Sela G, Haim N. Abnoba-viscum (mistletoe extract) in metastatic colorectal carcinoma resistant to 5-fluorouracil and leucovorin-based chemotherapy. Med. Oncol. 2004;21(3):251-4.
69. Gilbar O, Iron G, Goren A. Adjustment to illness of cancer patients treated by complementary therapy along with conventional therapy. Patient Educ. Couns. 2001;44(3):243-9.
70. Ben-Arye E, Frenkel M, Bar-sela G, Stashefsky Margalit R, Hermoni D, Kuten A. Teaching Complementary Medicine at an Academic Oncology Department. Accepted for publication in J. Cancer Education. 2008;23(1):46-50.
71. Ben-Arye E, Frenkel M. An approach to teaching physicians about CAM in the treatment of cancer. Integr. Cancer Ther. 2004;3(3):208-213.
72. Said O, Khalil K, Fulder S, Azaizeh H. Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region. J. Ethnopharmacol. 2002;83(3):251-65.
73. Dudai N, Weinstein Y, Krup M, Rabinski T, Ofir R. Citral is a new inducer of caspase-3 in tumor cell lines. Planta Med. 2005;71(5):484-8.
74. Lev-Ari S, Vexler A, Starr A, Ashkenazy-Voghera M, Greif J, Aderka D, Ben-Yosef R. Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines. Cancer Invest. 2007;25(6):411-8.
75. Rubnov S, Kashman Y, Rabinowitz R, Schlesinger M, Mechoulam R. Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation. J. Nat. Prod. 2001;64(7):993-6.
76. Tamir S, Eizenberg M, Somjen D, Stern N, Shelach R, Kaye A, Vaya J. Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Cancer Res. 2000 ;60(20):5704-9.
77. Lansky EP, Harrison G, Froom P, Jiang WG. Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel. Invest New Drugs. 2005;23(2):121-2.
78. Hochman N, Houri-Haddad Y, Koblinski J, Wahl L, Roniger M, Bar-Sinai A, Weiss EI, Hochman J. Cranberry juice constituents impair lymphoma growth and augment the generation of antilymphoma antibodies in syngeneic mice. Nutr. Cancer. 2008;60(4):511-7.
79. Hong-Fen L, Waisman T, Maimon Y, Shakhar K, Rosenne E, Ben-Eliyahu S. The effects of a Chinese herb formula, anti-cancer number one (ACNO), on NK cell activity and tumor metastasis in rats. Int. Immunopharmacol. 2001;1(11):1947-56.
80. Bar-Sela G, Tsalic M, Fried G, Goldberg H. Wheat grass juice may improve hematological toxicity related to chemotherapy in breast cancer patients: a pilot study. Nutr. Cancer. 2007;58(1):43-8.
81. Bar-Sela G, Goldberg H, Beck D, Amit A, Kuten A. Reducing malignant ascites accumulation by repeated intraperitoneal administrations of a Viscum album extract. Anticancer Res. 2006;26(1B):709-13.
82. Bar-Sela G, Atid L, Danos S, Gabay N, Epelbaum R. Art therapy improved depression and influenced fatigue levels in cancer patients on chemotherapy. Psychooncology. 2007;16(11):980-4.
83. Oberbaum M, Yaniv I, Ben-Gal Y, Stein J, Ben-Zvi N, Freedman LS, Branski D. A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation. Cancer. 2001 1;92(3):684-90.
84. Baider L, Peretz T, Hadani PE, Koch U. Psychological intervention in cancer patients:a randomized study. Gen. Hosp. Psychiatry. 2001;23(5):272-7.
85. Schiff E, Mogilner GJ, Sella E, Doweck I, Hershko O, Ben-Arye E, Yarom N. Hypnosis for Post-Radiation Xerostomia in Head and Neck Cancer Patients: A Pilot Study. Journal of Pain and Symptom Management. 2009;37(6):1086-1092.
86. Rezaei M, Adib-Hajbaghery M, Seyedfatemi N, Hoseini F (2008) Prayer in Iranian cancer patients undergoing chemotherapy. Complement Ther. Clin. Pract 14(2):90-97.
87. Geva H, Bar-Sela G, Zhana D, Mashiach T, Robinson E. The use of complementary and alternative therapies by cancer patients in northern Israel. Isr Med Assoc J. 2005 7(4):243-7.
88. Montazeri A, Sajadian A, Ebrahimi M, Akbari ME. Depression and the use of complementary medicine among breast cancer patients. Support Care Cancer. 2005;13(5):339-42.
89. Montazeri A, Sajadian A, Ebrahimi M, Haghighat S, Harirchi I. Factors predicting the use of complementary and alternative therapies among cancer patients in Iran. Eur. J. Cancer Care (Engl). 2007;16(2):144-9.
90. Emami SA, Sahebkar A, Tayarani-Najaran N, Tayarani-Najaran Z. Cancer and its Treatment in Main Ancient Books of Islamic Iranian Traditional Medicine (7th to 14th Century AD. Iran Red Crescent Me.d J. 2012;14(12):747-57.
91. Khorami Markani A, Yaghmaei F, Khodayari Fard M. Spirituality as experienced by Muslim oncology nurses in Iran. Br. J. Nurs. 2013;22(4):S22-4, S26-8.
92. Montazeri A, Sajadian A, Ebrahimi M, Akbari ME. Depression and the use of complementary medicine among breast cancer patients. Support Care Cancer. 2005;13(5):339-42.
93. Harandy TF, Ghofranipour F, Montazeri A, Anoosheh M, Bazargan M, Mohammadi E, Ahmadi F, Niknami S. Muslim breast cancer survivor spirituality: coping strategy or health seeking behavior hindrance? Health Care Women Int. 2010;31(1):88-98.
94. Ahmadi A, Mohagheghi MA, Fazeli MS, Nahavandian B, Bashardoost N, Musavi Jarahi A, Gharipoor M. HESA-A: new treatment for breast cancer and choroidal metastasis. Med. Sci. Monit. 2005;11(6):CR300-303.
95. Amirghofran Z, Bahmani M, Azadmehr A, Javidnia K. Anticancer effects of various Iranian native medicinal plants on human tumor cell lines. Neoplasma. 2006;53(5):428-33.
96. Tavakkol-Afshari J, Brook A, Mousavi SH. Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem. Toxicol. 2008;46(11):3443-7.
97. Feizzadeh B, Afshari JT, Rakhshandeh H, Rahimi A, Brook A, Doosti H. Cytotoxic effect of saffron stigma aqueous extract on human transitional cell carcinoma and mouse fibroblast. Urol. J. 2008;5(3):161-7.
98. Amirghofran Z, Bahmani M, Azadmehr A, Ashouri E, Javidnia K. Antitumor activity and apoptosis induction in human cancer cell lines by Dionysia termeana. Cancer Invest. 2007;25(7):550-4.
99. Varamini P, Javidnia K, Soltani M, Mehdipour AR, Ghaderi A. Cytotoxic activity and cell cycle analysis of quinoline alkaloids isolated from Haplophyllum canaliculatum Boiss. Planta Med. 2009;75(14):1509-16.
100. Amirghofran Z, Bahmani M, Azadmehr A, Javidnia K. Induction of apoptosis in leukemia cell lines by Linum persicum and Euphorbia cheiradenia. J. Cancer Res. Clin. Oncol. 2006;132(7):427-32.
101. Varamini P, Soltani M, Ghaderi A. Cell cycle analysis and cytotoxic potential of Ruta graveolens against human tumor cell lines. Neoplasma. 2009;56(6):490-3.
102. Rajabalian S. Methanolic extract of Teucrium polium L. potentiates the cytotoxic and apoptotic effects of anticancer drugs of vincristine, vinblastine and doxorubicin against a panel of cancerous cell lines. Exp. Oncol. 2008 ;30(2):133-8.
103. Amirghofran Z, Bahmani M, Azadmehr A, Javidnia K. Anticancer effects of various Iranian native medicinal plants on human tumor cell lines. Neoplasma. 2006;53(5):428-33.
104. Aghbali A, Hosseini SV, Delazar A, Gharavi NK, Shahneh FZ, Orangi M, Bandehagh A, Baradaran B. Induction of apoptosis by grape seed extract (Vitis vinifera) in oral squamous cell carcinoma 4Bosn J. Basic Med. Sci. 2013;13(3):186-91.
105. Motallebnejad M, Akram S, Moghadamnia A, Moulana Z, Omidi S. The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J. Contemp Dent Pract. 2008 Mar 1;9(3):40-7.
106. Mansouri A, Hadjibabaie M, Iravani M, Shamshiri AR, Hayatshahi A, Javadi MR, Khoee SH, Alimoghaddam K, Ghavamzadeh A. The effect of zinc sulfate in the prevention of high-dose chemotherapy-induced mucositis: a double-blind, randomized, placebo-controlled study. Hematol. Oncol. 2012;30(1):22-6.
107. Yekta ZP, Ebrahimi SM, Hosseini M, Nasrabadi AN, Sedighi S, Surmaghi MH, Madani H. Ginger as a miracle against chemotherapy-induced vomiting. Iran J. Nurs Midwifery Res. 2012;17(5):325-9.
108. Panahi Y, Saadat A, Sahebkar A, Hashemian F, Taghikhani M, Abolhasani E. Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: a pilot, randomized, open-label clinical trial. Integr. Cancer Ther. 2012;11(3):204-11.
109. Ahmadi A, Mohagheghi M, Karimi M, Golestanha SA, Naseri M, Faghihzadeh S, Habibi G. Therapeutic effects of HESA-A in patients with end-stage metastatic cancers. Integr. Cancer Ther. 2010;9(1):32-5.
110. Ahmadi A, Mohagheghi M, Karimi M, Seyed Ali Golestanha, Naseri M. Anticancer effects of HESA-A in patients with metastatic colon cancer. Integr. Cancer Ther. 2009;8(1):71-4.
111. Ahmadi A, Mohagheghi MA, Fazeli MS, Nahavandian B, Bashardoost N, Musavi Jarahi A, Gharipoor M. HESA-A: new treatment for breast cancer and choroidal metastasis. Med. Sci. Monit. 2005;11(6):CR300-303.
112. Rezaei M, Adib-Hajbaghery M, Seyedfatemi N, Hoseini F. Prayer in Iranian cancer patients undergoing chemotherapy.Complement Ther. Clin. Pract. 2008;14(2):90-7.
113. Bahrami M, Balouchestani E, Amini A, Eghbali M. Assessing the effect of two praying methods on the life quality of patients suffering from cancer hospitalized at Seyedo Shohada medical center of Isfahan University of Medical Sciences. Iran J. Nurs Midwifery Res. 2010;15(Suppl 1):296-301.
114. Jafari N, Zamani A, Farajzadegan Z, Bahrami F, Emami H, Loghmani A. The effect of spiritual therapy for improving the quality of life of women with breast cancer: a randomized controlled trial 4Psychol. Health Med. 2013;18(1):56-69.
115. Aghabati N, Mohammadi E, Pour Esmaiel Z. The Effect of Therapeutic Touch on Pain and Fatigue of Cancer Patients Undergoing Chemotherapy. Evid. Based Complement Alternat Med. 2008. [Epub ahead of print].
116. Ghoreishi Z, Esfahani A, Djazayeri A, Djalali M, Golestan B, Ayromlou H, Hashemzade S, Asghari Jafarabadi M, Montazeri V, Keshavarz SA, Darabi M. Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: a randomized double-blind placebo controlled trial. BMC Cancer. 2012;12:355.
117. Afifi FU, Wazaify M, Jabr M, Treish E. The use of herbal preparations as complementary and alternative medicine (CAM) in a sample of patients with cancer in Jordan. Complementary Therapies in Clinical Practice, 2010; 16(4):208-212.
118. Ali-Shtayeh MS, Jamous RM, Jamous RM. Herbal preparation use by patients suffering from cancer in Palestine, Complementary Therapies in Clinical Practice. In press, 2011.
119. Naja F, Alameddine M, Abboud M, Bustami D, Al Halaby R. Complementary and Alternative Medicine Use Among Pediatric Patients With Leukemia: The Case of Lebanon. Integr. Cancer Ther. 2010 Nov 8.
120. Al-Qudimat MR, Rozmus CL, Farhan N. Family strategies for managing childhood cancer: using complementary and alternative medicine in Jordan. J. Adv. Nurs. 2011 ;67(3):591-7.
121. Afifi-Yazar FU, Kasabri V, Abu-Dahab R. Medicinal Plants from Jordan in the Treatment of Cancer: Traditional Uses v. In vitro and In Vivo Evaluations - Part 1. Planta Med. 2011;77(11):1203-9.
122. Abuharfeil NM, Salim M, Von Kleist S. Augmentation of natural killer cell activity in vivo against tumour cells by some wild plants from Jordan. Phytother Res. 2001. 15:109-13.
123. Ali-Shtayeh MS, Daoud RTE, Jamous RM. Studies on folkloric medicinal plants used by Palestinians in the Qalqilia District. Biodiversity and Environmental Sciences Studies Series, 2010. 5(2).
124. Ali-Shtayeh MS, Jamous RM, Al-Shafie' JH, Elgharabah WA, Kherfan FA, Qarariah KH, Khdair IS, Soos IM, Musleh AA, Isa BA, Herzallah HM, Khlaif RB, Aiash SM, Swaiti GM, Abuzahra MA, Haj-Ali MM, Saifi NA, Azem HK, Nasrallah HA. Traditional knowledge of wild edible plants used in Palestine (Northern West Bank): a comparative stud. J. Ethnobiol. Ethnomed. 2008. 12;4:13.
125. Ali-Shtayeh MS, Jamous RM. Ethnobotany of Palestinian herbal medicine in the northern West Bank and Gaza Strip: review and comprehensive field study. Biodiversity and Environmental Sciences Studies Series. 2006;4:1-122.
126. Ali-Shtayeh MS, Yaniv Z, Mahajna J Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicinal plants. J. Ethnopharmacol. 2000;73(1-2):221-324
127. Kaileh M, Berghe WV, Boone E, Essawi T, Haegeman G. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J. Ethnopharmacol. 2007.113:510-6.
128. Jaradat NA. Ethnopharmacological Survey of Natural Products in Palestine. An-Najah Univ. J. Res. (N. Sc.), 2005. 19: 13-67.
129. Alali FQ, Tawaha K, El-Elimat T, Qasaymeh R, Li C, Burgess J, Nakanishi Y, Kroll DJ, Wani MC, Oberlies N H. Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum feinbr (Colchicaceae):2 native Jordanian meadow saffrons. Natural Product research, Part a: Structure and Synthesis. 2006; 20: 558-566.
130. Zihlif M, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R. Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan. Planta Med. 2012 Feb;78(3):297-301.
131. Abu-Dahab R, Afifi F. Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7). Scientia Pharmaceutica (Sci. Pharm.). 2007;75:121-136.
132. Abuharfeil NM, Maraqa A, Von Kleist S. Augmentation of natural killer cell activity in vitro against tumor cells by wild plants from Jordan. J. Ethnopharmacol. 2000;71(1-2):55-634
133. Tohme R, Al Aaraj L, Ghaddar T, Gali-Muhtasib H, Saliba NA, Darwiche N. Differential growth inhibitory effects of highly oxygenated guaianolides isolated from the Middle Eastern indigenous plant Achillea falcata in HCT-116 colorectal cancer cells. Molecules. 2013;18(7):8275-88.
134. El-Najjar N, Dakdouki S, Darwiche N, El-Sabban M, Saliba NA, Gali-Muhtasib H. Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. Oncol. Rep. 2008;19(4):897-904.
135. Al-Kalaldeh JZ, Abu-Dahab R, Afifi FU. Volatile oil composition and antiproliferative activity of Laurus nobilis, Origanum syriacum, Origanum vulgare, and Salvia triloba against human breast adenocarcinoma cells. Nutr. Res. 2010;30(4):271-8.
136. Abdel-Massih RM, Fares R, Bazzi S, El-Chami N, Baydoun E. The apoptotic and antiproliferative activity of Origanum majorana extracts on human leukemic cell line. Leuk Res. 2010;34(8):1052-6.
137. Fiore G, Nencini C, Cavallo F, Capasso A, Bader A, Giorgi G, Micheli L. In vitro antiproliferative effect of six Salvia species on human tumor cell lines. Phytother Res. 2006;20(8):701-703.
138. Deeb SJ, El-Baba CO, Hassan SB, Larsson RL, Gali-Muhtasib HU. Sage components enhance cell death through nuclear factor kappa-B signaling. Front Biosci. (Elite Ed). 2011;3:410-20.
139. Itani WS, El-Banna SH, Hassan SB, Larsson RL, Bazarbachi A, Gali-Muhtasib HU. Anti colon cancer components from lebanese sage (Salvia libanotica) essential oil:Mechanistic basis. Cancer Biol. Ther. 2008 7(11).
140. Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A, Schneider-Stock R. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int. J. Oncol. 2004;25(4):857-66.
141. Hasan TN, Shafi G, Syed NA, Alfawaz MA, Alsaif MA, Munshi A, Lei KY, Alshatwi AA. Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis. Nat. Prod. Commun. 2013;8(2):213-6.
142. Salim EI, Fukushima S. Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. Nutr. Cancer. 2003;45(2):195-202.
143. el-Aziz MA, Hassan HA, Mohamed MH, Meki AR, Abdel-Ghaffar SK, Hussein MR. The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model. Int. J. Exp. Pathol. 2005;86(6):383-96.
144. Mabrouk GM, Moselhy SS, Zohny SF, Ali EM, Helal TE, Amin AA, Khalifa AA. Inhibition of methylnitrosourea (MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawely rats. J. Exp. Clin. Cancer Res. 2002;21(3):341-6.
145. Elkady AI, Abuzinadah OA, Baeshen NA, Rahmy TR. Differential control of growth, apoptotic activity, and gene expression in human breast cancer cells by extracts derived from medicinal herbs Zingiber officinale. J. Biomed. Biotechnol. 2012;2012:614356.
146. Elamin MH, Daghestani MH, Omer SA, Elobeid MA, Virk P, Al-Olayan EM, Hassan ZK, Mohammed OB, Aboussekhra A. Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells. Food Chem. Toxicol. 2013;53:310-6.
147. Esmat A Hassan , Kamilia A B. (Studies on plants with special reference to their potential use in cancer care research. Improving productivity and accumulation of principal active components in fennel plant. Egyptian Journal of Applied Science. 2010; 25 (6A) :187-196.
148. Al-Daghri NM, Alokail MS, Alkharfy KM, Mohammed AK, Abd-Alrahman SH, Yakout SM, Amer OE, Krishnaswamy S. Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells. BMC Complement Altern Med. 2012;12:202.
149. Khoja KK, Shaf G, Hasan TN, Syed NA, Al-Khalifa AS, Al-Assaf AH, Alshatwi AA. Fenugreek, a naturally occurring edible spice, kills MCF-7 human breast cancer cells via an apoptotic pathway. Asian Pac. J. Cancer Prev. 2011;12(12):3299-304.
150. Mohamad RH, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats. J. Med. Food. 2009;12(2):394-402.
151. Mothana RA, Lindequist U, Gruenert R, Bednarski PJ. Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra. BMC Complement Altern Med. 2009;9:7.
152. Mothana RA, Grünert R, Lindequist U, Bednarski PJ. Study of the anticancer potential of Yemeni plants used in folk medicine. Pharmazie. 2007;62(4):305-7.
153. Mothana RA, Kriegisch S, Harms M, Wende K, Lindequist U. Assessment of selected Yemeni medicinal plants for their in vitro antimicrobial, anticancer, and antioxidant activities. Pharm. Biol. 2011;49(2):200-10.
154. Mahassni SH, Al-Reemi RM. Apoptosis and necrosis of human breast cancer cells by an aqueous extract of garden cress (Lepidium sativum) seeds.Saudi J. Biol. Sci. 2013;20(2):131-9.
155. El-Obeid A, Al-Harbi S, Al-Jomah N, Hassib A. Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Phytomedicine. 2006;13(5):324-33.
156. Hawas UW, Gamal-Eldeen AM, El-Toumy SA, Meyer JJ, Hussein AA. Inhibition of the initiation stage of carcinogenesis by Salvia disermas constituents. Z Naturforsch C. 2009;64(11-12):831-9.
157. El-Shemy HA, Aboul-Enein AM, Aboul-Enein MI, Issa SI, Fujita K. The effect of willow leaf extracts on human leukemic cells in vitro. J. Biochem. Mol. Biol. 2003;36(4):387-9.
158. Kamilia AB, Elmakawy AI, Abdelsalam A Z E , Daewish AM. Evaluation of antimutagenic activity of lettuce leaves against genotoxicity of chlorpyifos low doses in male mice. J. of Comunicata Scientiae. 2010 ( in press).
159. Rashad UM, Al-Gezawy SM, El-Gezawy E, Azzaz AN. Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer. J. Laryngol Otol. 2008 May 19:1-6.
160. Mabed M, El-Helw L, Shamaa S. Phase II study of viscum fraxini-2 in patients with advanced hepatocellular carcinoma. Br. J. Cancer. 2004;90(1):65-9.
161. Jazieh AR, Al Sudairy R, Abulkhair O, Alaskar A, Al Safi F, Sheblaq N, Young S, Issa M, Tamim H. Use of complementary and alternative medicine by patients with cancer in Saudi Arabia 4J. Altern Complement Med. 2012;18(11):1045-9.
162. Bogusz MJ, al Tufail M, Hassan H. How natural are 'natural herbal remedies'? A Saudi perspective. Adverse Drug React Toxicol Rev. 2002;21(4):219-29.
163. Albedah AM. Use of Complementary and Alternative Medicine by Cancer Patients in Saudi Arabia: A Paradox in Healthcare. J. Altern Complement Med. 2013 Apr 26. [Epub ahead of print].
164. Brahmi SA, El M'rabet FZ, Benbrahim Z, Akesbi Y, Amine B, Nejjari C, El Mesbahi O. Complementary medicine use among Moroccan patients with cancer: a descriptive study. Pan Afr. Med. J. 2011;10:36.
165. Hessissen L, Bhour M, El Kababri M, Kili A, Nachef MN, Elkhorassani M, Khattab M. Use of alternative medicine in a Moroccan pediatric oncology unit. J. Afr Cancer. 2011. DOI 10.1007/s12558-011-0177-6.
166. Tazi I, Nafil H, Sifesalam M, Bouchtia M, Mahmal L. Prevalence of complementary and alternative medicine use in patients with hematological malignancies in Marrakech, Morocco. J. Acupunct Meridian Stud. 2013;6(2):67-8.
167. Errihani H, Mrabti H, Boutayeb S, El Ghissassi I, El Mesbahi O, Hammoudi M, Chergui H, Riadi A. Impact of cancer on Moslem patients in Morocco. Psychooncology. 2008;17(1):98-100.
168. Merghoub N, Benbacer L, Amzazi S, Morjani H, El mzibri M. Cytotoxic effect of some Moroccan medicinal plant extracts on human cervical cell lines. Journal of Medicinal Plants Research, 2009; 3(12):1045-1050.
169. Chaouki W, Leger DY, Liagre B, Beneytout JL, Hmamouchi M. Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells. Fundam Clin. Pharmacol. 2009;23(5):549-56.
170. Lamchouri F, Settaf A, Cherrah Y, Hassar M, Zemzami M, Atif N, Nadori EB, Zaid A, Lyoussi B. In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines. Fitoterapia. 2000;71(1):50-4.
171. Abdeljebbar LH, Benjouad A, Morjani H, Merghoub N, El Haddar S, Humam M, Christen P, Hostettmann K, Bekkouche K, Amzazi S. Antiproliferative effects of withanolides from Withania adpressa. Therapie. 2009;64(2):121-7.
172. Abdeljebbar LH, Benjouad A, Morjani H, Merghoub N, El Haddar S, Humam M, Christen P, Hostettmann K, Bekkouche K, Amzazi S. Kilani-Jaziri S, Neffati A, Limem I, Boubaker J, Skandrani I, Sghair MB, Bouhlel I, Bhouri W, Mariotte AM, Ghedira K, Dijoux Franca MG, Chekir-Ghedira L.Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells. Chem Biol Interact. 2009;181(1):85-94.
173. Taamalli A, Arráez-Román D, Barrajón-Catalán E, Ruiz-Torres V, Pérez-Sánchez A, Herrero M, Ibañez E, Micol V, Zarrouk M, Segura-Carretero A, Fernández-Gutiérrez A. Use of advanced techniques for the extraction of phenolic compounds from Tunisian olive leaves: phenolic composition and cytotoxicity against human breast cancer cells. Food Chem. Toxicol. 2012 Jun;50(6):1817-25.
174. El Bouzidi L, Mahiou-Leddet V, Bun SS, Larhsini M, Abbad A, Markouk M, Fathi M, Boudon M, Ollivier E, Bekkouche K. Cytotoxic withanolides from the leaves of Moroccan Withania frutescens. Pharm Biol. 2013;51(8):1040-6.
175. Internet site: http://www.eurekalert.org/pub_releases/2001-09/gumc-gr090401.php accessed: 2 October 2013.
176. Yang AK, He SM, Liu L, Liu JP, Wei MQ, Zhou SF. Herbal interactions with anticancer drugs: mechanistic and clinical considerations. Curr. Med. Chem. 2010;17(16):1635-78.
177. McCulloch M, See C, Shu XJ, Broffman M, Kramer A, Fan WY, Gao J, Lieb W, Shieh K, Colford JM Jr. Astragalus-based Chinese herbs and platinum-based chemotherapy for advanced non-small-cell lung cancer: meta-analysis of randomized trials. J. Clin. Oncol. 2006;24(3):419-30.
178. Bokmand S, Flyger H. Acupuncture relieves menopausal discomfort in breast cancer patients: a prospective, double blinded, randomized study. Breast. 2013;22(3):320-3.
179. Barton DL, Liu H, Dakhil SR, Linquist B, Sloan JA, Nichols CR, McGinn TW, Stella PJ, Seeger GR, Sood A, Loprinzi CL. Wisconsin Ginseng (Panax quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind Trial, N07C24 J. Natl. Cancer Inst. 2013;105(16):1230-8.
180. Popper-Giveon A, Schiff E, Ben-Arye E. We and They in the House of Healing:Debate Among Arab Complementary Medicine Practitioners on an Integrative Versus Alternative Approach to Supportive Cancer Care. Integr. Cancer Ther. 2013 Apr 26. [Epub ahead of print].
181. Silbermann M, Dweib Khleif A, Balducci L: Healing by cancer. J. Clin. Oncol. 28(8):1436-1437, 2010.