Medicinal plants from jordan in the treatment of cancer: Traditional uses vs in vitro and in vivo evaluations part 1

Planta Medica

Volumn 77, Issue 11, 2011, Pages 1203-1209

  Afifi Yazar, Fatma U ^a   Kasabri, Violet ^a   Abu Dahab, Rana ^a  

^a UNIVERSITY OF JORDAN   (Jordan)

Author keywords

cancer; Jordan; medicinal plants; traditional medicine

Indexed keywords

ANAGYRIS FOETIDA EXTRACT; ANTHEMIS PSEUDOCOTULA EXTRACT; ANTINEOPLASTIC AGENT; ARBUTUS ANDRACHNE EXTRACT; ARUM DIOSCORIDIS EXTRACT; ARUM HYGROPHILUM EXTRACT; ARUM PALAESTINUM EXTRACT; CALENDULA ARVENSIS EXTRACT; CLEMATIS FLAMMULA EXTRACT; COCCULUS PENDULUS EXTRACT; CRATAEGUS AZAROLUS EXTRACT; HEDELIX; INULA VISCOSA EXTRACT; LAURUS NOBILIS EXTRACT; LUFFA CYLINDRICA EXTRACT; MERCURIALIS ANNUA EXTRACT; NARCISSUS TAZETTA EXTRACT; ONION EXTRACT; ONONIS SICULA EXTRACT; PLANT EXTRACT; PLATANUS ORIENTALIS EXTRACT; QUERCUS CALLIPRINOS EXTRACT; SARCOPOTERIUM EXTRACT; UNCLASSIFIED DRUG; URTICA PILULIFERA EXTRACT; VISCUM CRUCIATUM EXTRACT; WHEAT EXTRACT; ZIZYPHUS SPINA CHRISTI EXTRACT;

ALTERNATIVE MEDICINE; ANAGYRIS FOETIDA; ANTHEMIS PSEUDOCOTULA; ANTINEOPLASTIC ACTIVITY; ARBUTUS ANDRACHNE; ARUM DIOSCORIDIS; ARUM HYGROPHILUM; ARUM PALAESTINUM; BLADDER CANCER; BREAST CANCER; CALENDULA ARVENSIS; CLEMATIS FLAMMULA; COCCULUS PENDULUS; COLON CANCER; CRATAEGUS AZAROLUS; DRUG ACTIVITY; ECOSYSTEM; FLOWER; FRUIT; IN VITRO STUDY; IN VIVO STUDY; INULA VISCOSA; IVY; JORDAN; LAURUS NOBILIS; LUFFA CYLINDRICA; MEDICINAL PLANT; MERCURIALIS ANNUA; NARCISSUS TAZETTA; NEOPLASM; NONHODGKIN LYMPHOMA; NONHUMAN; ONION; ONONIS SICULA; PHYTOTHERAPY; PLANT; PLANT LEAF; PLANT ROOT; PLANT SEED; PLATANUS ORIENTALIS; QUERCUS CALLIPRINOS; RANDOMIZED CONTROLLED TRIAL; REVIEW; SARCOPOTERIUM; TRADITIONAL MEDICINE; URTICA PILULIFERA; VISCUM CRUCIATUM; WHEAT; ZIZYPHUS SPINA CHRISTI;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; ETHNOPHARMACOLOGY; HUMANS; JORDAN; MEDICINE, TRADITIONAL; NEOPLASMS; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT PREPARATIONS; PLANTS, MEDICINAL;

EID: 79960782221     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1270832     Document Type: Review

References (143)

1. Al-Eisawi D, El-Oqlah A, Al-Khader I A. Jordan Country Study on Biological Diversity. United Nations Environmental Program, 2000. Amman Al-Rai Commercial Press 2000 7-11
2. Al-Eisawi D M. List of Jordan vascular plants. Mitt Bot München 1982 18 79-182
3. Al-Eisawi D M. Vegetation of Jordan. Cairo UNESCO-Regional Office for Science and Technology for the Arab States 1996 266
4. Al-Khalil S. A survey of plants used in Jordanian traditional medicine. Int J Pharmacognosy 1995 33 317-323 (Pubitemid 26080572)
5. Azaizeh H, Fulder S, Khalil K, Said O. Ethnobotanical knowledge of local Arab practitioners in the Middle Eastern region. Fitoterapia 2003 74 98-108 (Pubitemid 36287252)
6. Bonet M A., Valles J. Use of non-crop food vascular plants in Montseny biosphere reserve (Catalonia, Iberian Peninsula). Int J Food Sci Nutr 2002 53 225-248 (Pubitemid 34272259)
7. Butler M S. The role of natural product chemistry in drug discovery. J Nat Prod 2004 67 2141-2153 (Pubitemid 40092578)
8. Goldman P. Herbal medicines today and the roots of modern pharmacology. Ann Intern Med 2001 135 594-600 (Pubitemid 33010195)
9. Phillipson J D. Phytochemistry and medicinal plants. Phytochemistry 2001 56 237-243 (Pubitemid 32162796)
10. Newman D J., Cragg G M., Snader K M. Natural products as sources of new drugs over the period 19812001. J Nat Prod 2003 66 1022-1037 (Pubitemid 36909859)
11. Abu-Rabia A. Herbs as a food and medicine source in Palestine. Asian Pac J Cancer Prev 2005 6 404-407
12. Nobili S, Lippi D, Witort E, Donnini M, Bausi L, Mini E, Capaccioli S. Natural compounds for cancer treatment and prevention. Pharmacol Res 2009 59 365-378
13. Afifi F U., Wazaify M, Jabr M, Treish E. The use of herbal preparations as complementary and alternative medicine (CAM) in a sample of patients with cancer in Jordan. Complement Ther Clin Pract 2010 16 208-212
14. Oran S A., Al-Eisawi D M. Check list of medicinal plants in Jordan. Dirasat 1998 25 84-112
15. Abu-Rmailah B, Afifi F. Treatment with medicinal plants in Jordan. Dirasat 2000 27 53-74
16. Al-Aboudi A, Afifi F U. Plants used for the treatment of diabetes in Jordan: A review of scientific evidence. Pharm Biol 2011 49 221-239
17. Camejo-Rodrigues J, Ascensao L, Bonet M A., Valles J. An ethnobotanical study of medicinal and aromatic plants in the Natural Park of Serra de Sao Mamede (Portugal). J Ethnopharmacol 2003 89 199-209 (Pubitemid 37383738)
18. Jeambey Z, Johns T, Talhouk S, Batal M. Perceived health and medicinal properties of six species of wild edible plants in north-east Lebanon. Public Health Nutr 2009 12 1902-1911
19. Ali-Shtayeh M S., Yaniv Z, Mahajna J. Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicinal plants. J Ethnopharmacol 2000 73 221-232
20. Said O, Khalil K, Fulder S, Azaizeh H. Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region. J Ethnopharmacol 2002 83 251-265 (Pubitemid 35333216)
21. Hudaib M, Mohammad M, Bustanji Y, Tayyeb R, Yousef M, Aburjeie M, Aburjai T. Ethnopharmacological survey of medicinal plants in Jordan, Mujib Nature Reserve and surrounding area. J Ethnopharmacol 2008 120 63-71
22. Al-Qura'n S. Ethnopharmacological survey of wild medicinal plants in Showbak, Jordan. J Ethnopharmacol 2009 123 45-50
23. Talib W H., Mahasneh A M. Antiproliferative activity of plant extracts used against cancer in traditional medicine. Sci Pharm 2010 78 33-45
24. WHO. WHO projections of the global burden of disease including cancer: 2004-2030. http://www.who.int/healthinfo/global-burden-disease/projections/en/ index.html Accessed January 1, 2011[nl]
25. Tarawneh M, Nimri O. Cancer incidence in Jordan. Jordan Cancer Registry. Jordan Ministry of Health 2007
26. King Hussein Cancer Centre. Jordanian cancer statistics for the year 2007. Amman KHCC publications 2007
27. Abu-Dahab R, Afifi F. Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7). Sci Pharm 2007 75 121-136 (Pubitemid 47605840)
28. Afifi-Yazar F U., Abu-Dahab R, Ismail S. Medicinal plants and anticancer activities: Experiences from Jordan using MCF7 cell lines. BIT Life Sciences' 1st Annual World Cancer Congress, Shanghai. 2008
29. Abu-Dahab R, Afifi-Yazar F U. Comparison of antiproliferative activities of ethanolic plant extracts of the Jordanian flora using MCF7 and A549 cells. Planta Med 2007 3 990
30. Al-Kalaldeh J Z., Abu-Dahab R, Afifi F U. Volatile oil composition and antiproliferative activity of Laurus nobilis, Origanum syriacum, Origanum vulgare and Salvia triloba against human breast adenocarcinoma cells. Nutr Res 2010 30 271-278
31. Gupta M. Pharmacological properties and traditional therapeutic uses of important Indian spices: A review. Int J Food Prop 2010 13 1092-1116
32. Faris M A., Takruri H R., Shomaf M S., Bustanji Y K. Chemopreventive effect of raw and cooked lentils (Lens culinaris L.) and soybeans (Glcine max) against azoxymethane-induced aberrant crypt foci. Nutr Res 2009 29 355-362
33. Khataibeh M, Abu-Alruz K, Al-Widyan O, Abu-Samak M, Al-Qudah J. Combined supplementation of soy and garlic modulate biochemical parameters of 7,12-dimethylbenz[alpha]anthracene induced mammary cancer in female albino rats. Pakistan J Biol Res 2007 10 2308-2313 (Pubitemid 47121358)
34. Abuherfeil N M., Maraqa A, Von Kleist S. Augmentation of natural killer cell activity in vitro against tumour cells by some wild plants from Jordan. J Ethnopharmacol 2000 71 55-63 (Pubitemid 30440652)
35. Shabsoug B, Khalil R, Abuherfeil N. Enhancement of natural killer cell activity in vitro against human tumour cells by some plants from Jordan. J Immunotoxicol 2008 5 279-285
36. Abuherfeil N M., Salim M, Von Kleist S. Augmentation of natural killer cell activity in vivo against tumour cells by some wild plants from Jordan. Phytother Res 2001 15 109-113
37. Fiore G, Nencini C, Cavallo F, Capasso A, Bader A, Giorgi G, Micheli L. In vitro antiproliferative effect of six Salvia species on human tumor cell lines. Phytother Res 2006 20 701-703
38. Kaileh M, Berghe W V., Boone E, Essawi T, Haegeman G. Screening of indigenous Palestinian plants for potential anti-inflammatory and cytotoxic activity. J Ethnopharmacol 2007 113 510-516 (Pubitemid 47371050)
39. Kaileh M, Vanden Berghe W, Heyerick A, Horion J, Piette J, Libert C, De Keukeleire D, Essawi T, Haegeman G. Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem 2007 282 4253-4264 (Pubitemid 47100978)
40. Alali F Q., El-Elimat T, Li C, Qandil A, Alkofahi A, Tawaha K, Burgess J P., Nakanishi Y, Kroll D J., Navarro H A., Falkinham III J O., Wani M C., Oberlies N H. New colchicinoids from a native Jordanian meadow saffron, Colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid. J Nat Prod 2005 68 173-178 (Pubitemid 40299801)
41. Alali F, Ma'aya'h A S., Alkofahi A, Qandil A, Li C, Burgess J P., Wani M C., Oberlies N H. A new colchicinoid from Colchicum tauri, an unexplored meadow saffron native to Jordan. Nat Prod Commun 2006 1 95-99
42. Alali F, Tawaha K, El-Elimat T, Qassaymeh R, Li C, Burgess J P., Yuka N, Kroll D J., Wani M C., Oberlies N Hl. Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons. Nat Prod Res 2006 20 558-566 (Pubitemid 43731133)
43. Alali F Q., Gharaibeh A, Ghawanmeh A, Tawaha K, Oberlies N H. Colchicinoids from Colchicum crocifolium Boiss.: a case study in dereplication strategies for ()-colchicine and related analogues using LC-MS and LC-PDA techniques. Phytochem Anal 2008 19 385-394
44. Al-Mahmoud M S., Alali F Q., Tawaha K, Qasaymeh R M. Phytochemical study and cytotoxicity evaluation of Colchicum stevenii Kunth (Colchicaceae): a Jordanian meadow saffron. Nat Prod Res 2006 20 153-160 (Pubitemid 43123628)
45. Alali F Q., Gharaibeh A A., Ghawanmeh A, Tawaha K, Qandil A, Burgess J P., Sy A, Nakanishi Y, Kroll D J., Oberlies N H. Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae). Nat Prod Res 2010 24 152-159
46. Alali F Q., Tahboub Y R., Ibrahim E S., Qandil A M., Tawaha K, Burgess J P., Sy A, Nakanishi Y, Kroll D J., Oberlies N H. Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae). Phytochemistry 2008 69 2341-2346
47. Rates S M. K. Plants as source of drugs. Toxicon 2001 39 603-613
48. Dorai T, Aggarwal B B. Role of chemopreventive agents in cancer therapy. Cancer Lett 2004 215 129-140 (Pubitemid 39370030)
49. Rabi T, Bishayee A. Terpenoids and breast cancer chemoprevention. Breast Cancer Res Treat 2009 115 223-239
50. Pezzuto J M. Resveratrol as an inhibitor of carcinogenesis. Pharm Biol 2008 46 443-573 (Pubitemid 351882326)
51. Amin A R., Kucuk O, Khuri F R., Shin D M. Perspectives for cancer prevention with natural compounds. J Clin Oncol 2009 27 2712-2715
52. Kasinski A L., Du Y, Thomas S L., Zhao J, Sun S Y., Khuri F R., Wang C Y., Shoji M, Sun A, Snyder J P., Liotta D, Fu H. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis (2-flurobenzylidene) piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol 2008 74 654-661
53. Rajabalian S. Methanolic extract of Teucrium polium L. potentiates the cytotoxic and apoptotic effects of anticancer drugs of vincristine, vinblastine and doxorubicin against a panel of cancerous cell lines. Exp Oncol 2008 30 133-138 (Pubitemid 351951390)
54. Sarkar F H., Li Y. Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics. Cancer Treat Rev 2009 35 597-607
55. Papas T S., Sandhaus L, Chirigos M A., Furusawa E. Inhibition of DNA polymerase of avian myeloblastosis virus by an alkaloid extract from Narcissus tazetta L. Biochem Biophys Res Commun 1973 52 88-92
56. Youssef D T., Khalifa A A. Cytotoxic quaternary alkaloids from the flowers of Narcissus tazetta. Pharmazie 2001 56 818-822 (Pubitemid 32971286)
57. Talib W H., Mahasneh A M. Antimicrobial, cytotoxicity and phytochemical screening of Jordanian plants used in traditional medicine. Molecules 2010 15 1811-1824
58. Kelling C L., Schipper I A., Schermeister L J., Vacik J P. Effects of crude extracts of various plants on infectious bovine rhinotracheitis virus-plaque production. Am J Vet Res 1976 37 215-218
59. Ooi L S., Tian L, Su M, Ho W S., Sun S S., Chung H Y., Wong H N., Ooi V E. Isolation, characterisation, molecular cloning and modelling of a new lipid transfer protein with antiviral and antiproliferative activities from Narcissus tazetta. Peptides 2008 29 2101-2109 (Pubitemid 50301167)
60. Khalil A, Dababneh B. Inhibition of phytopathogenic fungi by extracts from medicinal plants in Jordan. J Biol Sci 2007 7 579-581 (Pubitemid 46958089)
61. El-Desouky S K., Kim K H., Ryu S Y., Eweas A F., Gamal-Eldeen A M., Kim Y K. A new pyrrole alkaloid isolated from Arum palaestinum Boiss. and its biological activities. Arch Pharm Res 2007 30 927-931
62. Al-Mustafa A H., Al-Thunibat O Y. Antioxidant capacity of some Jordanian medicinal plants used traditionally for the treatment of diabetes. Pakistan J Biol Sci 2008 11 351-358
63. Majester-Savornin B, Elias R, Diaz-Lanza A M., Balansard G, Gasquet M, Delmas F. Saponins of the ivy plant, Hedera helix, and their leishmanicidic activity. Planta Med 1991 57 260-262
64. Demirci B, Goppel M, Demirci F, Franz G. HPLC profiling and quantification of active principles in leaves of Hedera helix L. Pharmazie 2004 59 770-774 (Pubitemid 39390247)
65. Facino R M., Carini M, Stefani R, Aldini G, Saibene L. Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency. Arch Pharm (Weinheim) 1995 328 720-724
66. Trute A, Gross J, Mutschler E, Nahrstedt A. In vitro antispasmodic compounds of the dry extract obtained from Hedera helix. Planta Med 1997 63 125-129 (Pubitemid 27196078)
67. Elias R, De Meo M, Vidal-Ollivier E, Laget M, Balansard G, Dumenil G. Antimutagenic activity of some saponins isolated from Calendula officinalis L., C. arvensis L. and Hedera helix L. Mutagenesis 1990 5 327-331 (Pubitemid 20334845)
68. Hofmann D, Hecker M, Volp A. Efficacy of dry extract of ivy leaves in children with bronchial asthmaa review of randomised controlled trials. Phytomedicine 2003 10 213-220 (Pubitemid 36433221)
69. Zarga M H., Sabri S S., Hamed E M., Khanfar M A., Zeller K P., Atta-Ur-Rahman. A new eudesmane type sesquiterpene from Inula viscosa. Nat Prod Res 2003 17 99-102 (Pubitemid 36575498)
70. Lauro L, Rolih C. Observations and research on an extract of Inula viscosa Ait. Boll Soc Ital Biol Sper 1990 66 829-834
71. Al-Dissi N M., Salhab A S., Al-Hajj H. Effects of Inula viscosa leaf extracts on abortion and implantation in rats. J Ethnopharmacol 2001 77 117-121 (Pubitemid 32727755)
72. Askin Celik T, Aslanturk O S. Evaluation of cytotoxicity and gentoxicity of Inula viscosa leaf extracts with Allium test. J Biomed Biotechnol
73. Zeggwagh N A., Ouahidi M L., Lemhadri A, Eddouks M. Study of hypoglycaemic and hypolidemic effects of Inula viscosa L. aqueous extract in normal and diabetic rats. J Ethnopharmacol 2006 108 223-227 (Pubitemid 44635029)
74. Chemli R, Toumi A, Queslati S, Zouaghi H, Boukef K, Balansard G. Calendula arvensis L. Impact of saponins on toxicity, haemolytic effect and anti-inflammatory activity. J Pharm Belg 1990 45 12-16 (Pubitemid 20154300)
75. De Tommasi N, Pizza C, Conti C, Orsi N, Stein M L. Structure and in vitro antiviral activity of sesquiterpene glycosides from Calendula arvensis. J Nat Prod 1990 53 830-835 (Pubitemid 20334542)
76. Saleh M M., Rizk A M. Flavonoids and coumarins of Anthemis pseudocotiola. Planta Med 1974 25 60-62
77. Yoshikawa K, Arihara S, Wang J D., Narui T, Okuyama T. Structures of two fibrinolytic saponins from seeds of Luffa cylindrica Roem. Chem Pharm Bull 1991 39 1185-1188
78. Khajuria A, Gupta A, Garai S, Wakhloo B P. Immunomodulatory effects of two saponins 1 and 2 isolated from Luffa cylindrica in Balb/C mice. Bioorg Med Chem Lett 2007 17 1608-1612 (Pubitemid 46274344)
79. Du Q, Cui H. A new flavone glycoside from the fruits of Luffa cylindrica. Fitoterapia 2007 78 609-610 (Pubitemid 47625904)
80. Ng T B., Chan W Y., Yeung H W. Proteins with abortifacient, ribosome inactivating, immunomodulatory, antitumor and anti-AIDS activities from Cucurbitaceae plants. Gen Pharmacol 1992 23 579-590
81. Ng T B., Wong R N., Yeung H W. Two proteins with ribosome-inactivating, cytotoxic and abortifacient activities from seeds of Luffa cylindrica roem (Cucurbitaceae). Biochem Int 1992 27 197-207
82. Du Q, Xu Y, Li L, Zhao Y, Jerz G, Winterhalter P. Antioxidant constituents in the fruits of Luffa cylindrica (L.) Roem. J Agric Food Chem 2006 54 4186-4190 (Pubitemid 44013320)
83. Poma A, Marcozzi G, Cesare P, Carmignanu M, Spano L. Antiproliferative effect and apoptotic response in vitro of human melanoma cells to liposomes containing the ribosome-inactivating protein luffin. Biochim Biophys Acta 1999 1472 197-205 (Pubitemid 29486530)
84. Lui L, Wang R, He W, He F, Huang G. Cloning and soluble expression of mature alpha-luffin from Luffa cylindrica and its antitumor activities in vitro. Acta Biochim Biophys Sin (Shanghai) 2010 42 585-592
85. Issa R A., Afifi F U., Amro B I. Studying the anti-tyrosinase effect of Arbustus andrachne L. extracts. Int J Cosmet Sci 2008 40 271-276 (Pubitemid 351989210)
86. Dumkow K. Flavonoids of domestic euphorbiaceae. 4. Flavonol glycosides of Mercurialis annua L. Z Naturforsch B 1969 24 1203
87. Hanus L O., Temina M, Dembitsky V. Biodiversity of the chemical constituents in the epiphytic lichenized ascomycete Ramalina lacera grown on difference substrates Crataegus sinaicus, Pinus halepensis, and Quercus calliprinos. Biomed Pap 2008 152 203-208
88. Yeruham I, Avidar Y, Perl S, Yakobson B, Shlosberg A, Hanji V, Bogin E. Probable toxicosis in cattle in Israel caused by the oak Quercus calliprinos. Vet Hum Toxicol 1998 40 336-340 (Pubitemid 28538907)
89. Elbetieha A, Oran S A., Alkofahi A, Darmnai H, Raies A M. Fetotoxic potentials of Globularia arabica and Globularia alypum (Globulariaceae) in rats. J Ethnopharmcol 2000 72 215-219
90. Oran S A., Raies A M. Antimicrobial activity of Globularia arabica Jaub. and Spach and G. alypum L. (Globulariaceae). Dirasat 2000 27 71-73
91. Sultan M M., Zaki A K. Antiviral screening of forty-two Egyptian medicinal plants. J Ethnopharmcol 2009 126 102-107
92. Dall'Aqua S, Cervellati R, Speroni E, Costa S, Guerra M C., Stella L, Greco E, Innocenti G. Phytochemical composition and antioxidant activity of Laurus nobilis L. leaf infusion. J Med Food 2009 12 869-876
93. Ferreira A, Proenca C, Serralheiro M L., Araujo M E. The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. J Ethnopharmacol 2006 108 31-37 (Pubitemid 44498982)
94. Panza E, Tersigni M, Iorizzi M, Zollo F, De Marino S, Festa C, Napolitano M, Castello G, Ialenti A, Ianaro A. Lauroside B, a megastigmane glycoside from Laurus nobilis (Bay Laurel) leaves, induces apoptosis in human melanoma cell lines by inhibiting NF- B activation. J Nat Prod
95. Innocenti G, Dall'Acqua S, Viola G, Loi M C. Cytotoxic constituents from Anagyris foetida leaves. Fitoterapia 2006 77 595-597 (Pubitemid 44738280)
96. Dias C, Borralho Graca J A., Lurdes Goncalves M. Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts. J Ethnopharmacol 2000 71 487-492 (Pubitemid 30642874)
97. Krenn L, Jelovina M, Kopp B. New bufadienolides from Urginea maritime sensu strictu. Fitoterapia 2000 71 126-129 (Pubitemid 30156002)
98. Civelek H S., Weintraub P G. Effects of two plant extracts on larval leafminer Liriomyza trifolii (Diptera: Agromyzidae) in tomatoes. J Econ Entomol 2004 97 1581-1586 (Pubitemid 39474595)
99. Mert M, Betul B. Cytogenetic effects of Urginea maritime L. aqueous extracts on the chromosomes by using Allium test method. Caryologia 2008 61 342-348
100. Boyle S P., Dobson V L., Duthie S J., Kyle J A., Collins A R. Absorption and DNA protective effects of flavonoid glycosides from an onion meal. Eur J Nutr 2000 39 213-223
101. Griffiths G, Trueman L, Crowther T, Thomas B, Smith B. Onionsa global benefit to health. Phytother Res 2002 16 603-615
102. Rose P, Whiteman M, Moore P K., Zhu Y Z. Bioactive S -alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Nat Prod Rep 2005 22 351-368 (Pubitemid 40885716)
103. Galluzzo P, Martini C, Bulzomi P, Leone S, Bolli A, Pallottini V, Marino M. Quercetin-induced apoptotic cascade in cancer cells: antioxidant versus estrogen receptor alpha-dependent mechanisms. Mol Nutr Food Res 2009 53 699-708
104. El-Aasr M, Fujiwara Y, Takeya M, Ikeda T, Tsukamoto S, Ono M, Nakano D, Okawa M, Kinjo J, Yoshimitsu H, Nohara T. Onionin A from Allium cepa inhibits macrophage activation. J Nat Prod 2010 73 1306-1308
105. Srinivasan K. Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts. Int J Food Sci Nutr 2005 56 399-414 (Pubitemid 43135377)
106. Hubbard G P., Wolffram S, de Vos R, Bovy A, Gibbins J M., Lovegrove J A. Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. Br J Nutr 2006 96 482-488
107. Sengupta A, Ghosh S, Bhattacharjee S. Allium vegetables in cancer prevention: an overview. Asian Pac J Cancer Prev 2004 5 237-245
108. González C A., Pera G, Agudo A, Bueno-de-Mesquita H B., Ceroti M, Boeing H, Schulz M, Del Giudice G, Plebani M, Carneiro F, Berrino F, Sacerdote C, Tumino R, Panico S, Berglund G, Simán H, Hallmans G, Stenling R, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quiros J R., Allen N, Key T J., Bingham S, Day N E., Linseisen J, Nagel G, Overvad K, Jensen M K., Olsen A, Tjønneland A, Büchner F L., Peeters P H., Numans M E., Clavel-Chapelon F, Boutron-Ruault M C., Roukos D, Trichopoulou A, Psaltopoulou T, Lund E, Casagrande C, Slimani N, Jenab M, Riboli E. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Int J Cancer 2006 118 2559-2566
109. Galasso R, Palli D, Tumino R, Vineis P, Trichopoulou A, Kalapothaki V, Trichopoulos D, Chang-Claude J, Linseisen J, Boutron-Ruault M C., Touillaud M, Clavel-Chapelon F, Olsen A, Tjønneland A, Overvad K, Tetsche M, Jenab M, Norat T, Kaaks R, Riboli E. Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev 2005 14 253-255
110. Galeone C, Pelucchi C, Dal Maso L, Negri E, Montella M, Zucchetto A, Talamini R, La Vecchia C. Allium vegetables intake and endometrial cancer risk. Public Health Nutr 2009 12 1576-1579
111. Ban J O., Hwang I G., Kim T M., Hwang B Y., Lee U S., Jeong H S., Yoon Y W., Kimz D J., Hong J T. Anti-proliferate and pro-apoptotic effects of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyranone through inactivation of NF-kappaB in human colon cancer cells. Arch Pharm Res 2007 30 1455-1463
112. Shrivastava S, Ganesh N. Tumour inhibition and cytotoxicity assay by aqueous extract of onion (Allium cepa) & garlic (Allium sativum): an in-vitro analysis. Int J Phytomed 2010 2 80-84
113. Martin-Cordero C, Lopez-Lazaro M, Agudo M A., Navarro E, Trujillo J, Ayus M J. A cytotoxic diarylheptanoid from Viscum cruciatum. Phytochemistry 2001 58 567-569 (Pubitemid 32910217)
114. Hass K, Bauer M, Wollenweber E. Cuticular waxes and flavonol aglycones of mistletoes. Z Naturforsch 2003 58 464-470 (Pubitemid 36971444)
115. Alali F Q., Tawaha K, El-Elimat T, Syouf M, Al-Fayad M, Abulaila K, Nielsen S J., Wheaton W D., Falkinham 3rd J O., Oberlies N H. Antioxidant activity and total phenolic content of aqueous and methanolic extracts of Jordanian plants: an ICBG project. Nat Prod Res 2007 21 1121-1131 (Pubitemid 47423488)
116. Saenz M T., Ahumada M C., Garcia M D. Extracts from Viscum and Crataegus are cytotoxic against larynx cancer cells. Z Naturforsch 1997 52 42-44 (Pubitemid 27155855)
117. Hussain S F., Khan L, Guinaudeau H, Leet J E., Freyer A J., Shamma M. The alkaloidal profile of Cocculus pendulus. Tetrahedron 1984 40 2513-2517
118. Atta-ur-Rahman. Isolation, structural and synthetic studies on the chemical constituents of medicinal plants of Pakistan. Pure Appl Chem 1986 58 663-673
119. Al-Khalil S, Al-Eisawi D, Sharaf M, Schiff Jr P L. Alkaloids of Cocculus pendulus. Planta Med 1993 59 276 (Pubitemid 23168781)
120. Atta-ur-Rahman, Atia-Tul-Wahab, Nawaz S A., Choudhary I M. New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Cocculus pendulus. Chem Pharm Bull (Tokyo) 2004 52 802-806 (Pubitemid 41679569)
121. Atta-ur-Rahman, Atia-Tul-Wahab, Zia Sultani S, Nawaz S A., Choudhary I M. Bisbenzylisoquinoline alkaloids from Cocculus pendulus. Nat Prod Res 2009 23 1265-1273
122. Qu H, Madl R L., Takemoto D J., Baybutt R C., Wang W. Lignans are involved in the antitumor activity of wheat bran in colon cancer SW480 cells. J Nutr 2005 135 598-602 (Pubitemid 40365224)
123. Borowicki A, Stein K, Scharlau D, Glei M. Fermentation supernatants of wheat (Triticum aestivum L.) aleurone beneficially modulate cancer progression in human colon cells. J Agric Food Chem 2010 58 2001-2007
124. Mitrokotsa D, Mitaku S, Demetzos C, Harvala C, Mentis A, Perez S, Kokkinopoulos D. Bioactive compounds from the buds of Plantanus orientalis and isolation of a new kaempferol glycoside. Planta Med 1993 59 517-520 (Pubitemid 24019539)
125. Dimas K, Demetzos C, Mitaku S, Marselos M, Tzavaras T, Kokkinopoulos D. Cytotoxic activity of kaempferol glycoside against human leukaemic cell lines in vitro. Pharmacol Res 2000 41 85-88 (Pubitemid 30008941)
126. Atmani D, Chaher N, Berboucha M, Ayouni K, Lounis H, Boudaoud H. Antioxidant capacity and phenol content of selected Algerian medicinal plants. Food Chem 2009 112 303-309
127. Dafni A, Levy S, Lev E. The ethnobotany of Christ's Thorne jujube (Ziziphus spina-christi) in Israel. J Ethnobiol Ethnomed 2005 1 8
128. Saied A S., Gebauer J, Hammer K, Buerkert A. Ziziphus spina-christi (L.) Willd: a multipurpose fruit tree. Genet Resour Crop Evol 2008 55 929-937
129. El-Din Hussein Mahran G, Glombitza K W., Mirhom Y W., Hartmann R, Michel C G. Novel saponins from Zizyphus spina-christi growing in Egypt. Planta Med 1996 62 163-165 (Pubitemid 26163223)
130. Shahat A A., Pieters L, Apers S, Nazeif N M., Abdel-Azim N S., Berghe D V., Vlietinck A J. Chemical and biological investigations on Zizyphus spina-christi L. Phytother Res 2001 15 593-597 (Pubitemid 33021865)
131. Abdel-Zaher A O., Salim S Y., Assaf M H., Abdel-Hady R H. Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. J Ethnopharmacol 2005 101 129-138 (Pubitemid 41265612)
132. Nesseem D I., Michel C G., Sleem A A., Al-Alfy T S. Formulation and evaluation of antihyperglycemic leaf extracts of Zizyphus spina-christi (L.) Willd. Pharmazie 2009 64 104-109
133. Michel C G., Nesseem D I., Ismail M F. Anti-diabetic activity and stability study of the formulated leaf extract of Zizyphus spina-christi (L.) Willd with the influence of seasonal variation. J Ethnopharmacol 2011 133 53-62
134. Abdel-Wahhab M A., Omara E A., Abdel-Galil M M., Hassan N S., Nada S A., Saeed A, el-Sayed M M. Zizyphus spina-christi extract protects against aflatoxin B1-initiated hepatic carcinogenicity. Afr J Tradit Complement Alternat Med 2007 4 248-256
135. Amin A, Mahmoud-Ghoneim D. Zizyphus spina-christi protects against carbon tetrachloride-induced liver fibrosis in rats. Food Chem Toxicol 2009 47 2111-2119
136. Godini A, Kazem M, Naseri G, Badavi M. The effect of Ziziphus spina-christi leaf extract on isolated rat aorta. JPMA 2009 53 537-539
137. Hadizadeh I, Peivastegan B, Kolahi M. Antifungal activity of nettle (Urtica dioica L.), colocynth (Citrullus colocynthis L. Schrad), oleander (Nerium oleander L.) and konar (Ziziphus spina-christi L.) extracts on plants pathogenic fungi. Pakistan J Biol Sci 2009 12 58-63
138. Reher G, Reznicek G, Baumann A. Triterpenoids from Sarcopoterium spinosum and Sanguisorba minor. Planta Med 1991 57 506
139. Kasabri V, Afifi F U., Hamdan I. In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine. J Ethnopharmacol 2011 27 888-896
140. Smirin P, Taler D, Abitbol G, Brutman-Barazani T, Kerem Z, Sampson S R., Rosenzweig T. Sarcopoterium spinosum extract as an antidiabetic agent: in vitro and in vivo study. J Ethnopharmacol 2010 129 10-17
141. Bashri-Sahloul R, Ammar S, Fredj R B., Saguem S, Grec S, Trotin F, Skhiri F H. Polyphenol contents and antioxidative activities of extracts from flowers of two Crataegus azarolus L. varieties. Pakistan J Biol Sci 2009 12 660-668
142. Ozen T, Collu Z, Korkmaz H. Antioxidant properties of Urtica pilulifera root, seed, flower and leaf extract. J Med Food 2010 13 1224-1231
143. Kavalali G, Tuncel H, Goksel S, Hatemi H H. Hypoglycaemic activity of Urtica pilulifera in streptozotocin-diabetic rats. J Ethnopharmacol 2003 84 241-245 (Pubitemid 36324263)