The apoptotic and anti-proliferative activity of Origanum majorana extracts on human leukemic cell line

Leukemia Research

Volumn 34, Issue 8, 2010, Pages 1052-1056

  Abdel Massih, Roula M ^a   Fares, Rida ^a   Bazzi, Samer ^a   El Chami, Nisrine ^b   Baydoun, Elias ^b  

^a UNIVERSITY OF BALAMAND   (Lebanon)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

ALL; Anti proliferative; Antioxidant; Apoptosis; DPPH; Origanum majorana

Indexed keywords

ORIGANUM MAJORANA EXTRACT; PROTEIN BCL 2; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; CYTOTOXICITY; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRY WEIGHT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; LYMPHATIC LEUKEMIA; NONHUMAN; OREGANO; ORIGANUM MAJORANA; PRIORITY JOURNAL; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CELL PROLIFERATION; FREE RADICAL SCAVENGERS; HUMANS; ORIGANUM; PHYTOTHERAPY; PICRATES; PLANT EXTRACTS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 77953611446     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2009.09.018     Document Type: Article

References (29)

1. Sari M., Biondi D.M., Kaabeche M., Mandalari G., D'Arrigo M., Bisignano G., et al. Chemical composition, antimicrobial and antioxidant activities of the essential oil of several populations of Algerian Origanum glandulosum Desf. Flavour and Fragrance Journal 2006, 21:890-898.
2. Vàgi E., Rapavi E., Hadolin M., Vásárhelyiné Perédi K., Balázs A., Blázovics A., et al. Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents. Journal of Agricultural and Food Chemistry 2005, 53:17-21.
3. Cipak L., Grausova L., Miadokova E., Novotny L., Rauko P. Dual activity of triterpenoids: apoptotic versus antidifferentiation effects. Archives of Toxicology 2006, 80:429-435.
4. El-Ashmawy I.M., El-Nahas A.F., Salama O.M. Protective effect of volatile oil, alcoholic and aqueous extracts of Origanum majorana on lead acetate toxicity in mice. Basic and Clinical Pharmacology and Toxicology 2005, 97:238-243.
5. Dapkevicius A., Venskutonis R., Van Beek T.A., Linssen J.P.H. Antioxidant activity of extracts obtained by different isolation procedures from some aromatic herbs grown in Lithuania. Journal of the Science of Food and Agriculture 1998, 77:140-146.
6. Tsimogiannis D., Stavrakaki M., Oreopoulou V. Isolation and characterisation of antioxidant components from Oregano (Origanum heracleoticum). International Journal of Food, Science, and Technology 2006, 41:39-48.
7. Niture S.K., Rao U.S., Srivenugopal K.S. Chemopreventative strategies targeting the MGMT repair protein: augmented expression in human lymphocytes and tumor cells by ethanolic and aqueous extracts of several Indian medicinal plants. International Journal of Oncology 2006, 29:1269-1278.
8. Bellosillo B., Pique M., Barragan M., Castano E., Villamor N., Colomer D., et al. Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells. Blood 1998, 92:1406-1414.
9. Zhu J., Lavrik I., Mahlknecht U., Giaisi M., Proksch P., Krammer P., et al. The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities. International Journal of Cancer 2007, 121:1839-1846.
10. Kumagai T., Muller C., Desmond J., Imai Y., Heber D., Koeffler H. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leukemia Research 2007, 31:523-530.
11. Lin L.T., Liu L.T., Chiang L.C., Lin C.C. In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytotherapy Research 2002, 16:440-444.
12. Yazdanparast R., Shahriyary L. Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion. Vascular Pharmacology 2008, 48:32-37.
13. Roshak A.K., Capper E.A., Stevenson C., Eichman C., Marshall L.A. Human calcium-independent phospholipase A2 mediates lymphocyte proliferation. The Journal of Biological Chemistry 2000, 275:35692-35698.
14. Lee S.K., Mbwambo Z.H., Chung H., Luyengi L., Gamez E.J., Mehta R.G., et al. Evaluation of the antioxidant potential of natural products. Combinatorial Chemistry and High throughput Screening 1998, 1:35-46.
15. Singleton V.L., Rossi J.A. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture 1965, 16:144-158.
16. Kahkonen M.P., Hopia A.I., Vuorela H.J., Rauha J.P., Pihlaja K., Kujala T.S., et al. Antioxidant activity of plant extracts containing phenolic compounds. Journal of Agriculture and Food Chemistry 1999, 47:3954-3962.
17. Littlefield J.W., Gould E.A. The toxic effect of 5-bromodeoxyuridine on cultured epithelial cells. Journal of Biological Chemistry 1960, 235:1129-1133.
18. Vermes I., Haanen C., Steffens-Nakken H., Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V. Journal of Immunological Methods 1995, 184:39-51.
19. Aherne S.A., Kerry J.P., O'Brien N.M. Effects of plant extracts on antioxidant status and oxidant-induced stress in Caco-2 cells. British Journal of Nutrition 2007, 97:321-328.
20. Harakeh S., Diab-Assef M., El-Sabban M., Haddadin M., Gali-Muhtasib H. Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7 dichloroquinoxaline 1,4-dioxide in adult T-cell leukemia cells. Chemico-Biological Interactions 2004, 148:101-113.
21. Chen Y.H., Chen H.Y., Hsu C.L., Yen G.C. Induction of apoptosis by the Lactua indica L. in human leukemia cell line and its active components. Journal of Agriculture and Food Sciences 2007, 55:1743-1749.
22. Hitoshi T., Yuka K., Takashi G., Kazuo K., Masato N. DPPH radical-scavenging effect of several phenylpropanoid compounds and their glycoside derivatives. Yakugaku Zasshi 2005, 125:371-375.
23. Matsuura H., Chiji H., Asakawa C., Amano M., Yoshihara T., Mizutani J. DPPH radical scavengers from dried leaves of Oregano (Origanum vulgare). Bioscience, Biotechnology, and Biochemistry 2003, 67:2311-2316.
24. Jasril Lajis N.H., Mooi L.Y., Abdullah M.A., Sukari M.A., Ali A.M. Antitumor promoting and antioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica. Asia Pacific Journal of Molecular Biology and Biotechnology 2003, 11:3-7.
25. Karakaya S., El S.N., Ta A.A. Antioxidant activity of some foods containing phenolic compounds. International Journal of Food Sciences and Nutrition 2001, 52:501-508.
26. Foley G.E., Lazarus H., Farber S., Uzman B.G., Boone B.A., McCarthy R.E. Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia. Cancer 1965, 18:522-529.
27. Harakeh S., Diab-Assaf M., Niedzweicki A., Khalife J., Abu-El-Ardat K., Rath M. Apoptosis induction by Epican Forte in HTLV-1 positive and negative malignant T-cells. Leukemia Research 2006, 30:869-881.
28. Jun W.J., Han B.K., Yu K.W., Kim M.S., Chang I.S., Kim H.Y., et al. Antioxidant effects of Origanum majorana L. on superoxide anion radicals. Food Chemistry 2001, 75:439-444.
29. O'Brien N.M., Carpenter R., O'Callaghan Y.C., O'Grady M.N., Kerry J.P. Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells. Journal of Medicinal Food 2006, 9:187-195.