The effect of topical application of pure honey on radiation-induced mucositis: A randomized clinical trial

Journal of Contemporary Dental Practice

Volumn 9, Issue 3, 2008, Pages 040-047

  Motallebnejad, M ^a   Akram, S ^a   Moghadamnia, A ^a   Moulana, Z ^a   Omidi, S ^b  

^a BABOL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Babol University of Medical Science ^*

Author keywords

Cancer; Honey; Mucositis; OMAS; Oral mucositis assessing scale; Radiotherapy

Indexed keywords

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HONEY; HUMAN; MALE; MIDDLE AGED; MUCOSA INFLAMMATION; NONPARAMETRIC TEST; OROPHARYNX TUMOR; RADIATION INJURY; RADIOISOTOPE THERAPY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SKULL IRRADIATION; STOMATITIS;

CRANIAL IRRADIATION; FEMALE; HONEY; HUMANS; MALE; MIDDLE AGED; MUCOSITIS; OROPHARYNGEAL NEOPLASMS; RADIATION INJURIES; RADIOISOTOPE TELETHERAPY; SINGLE-BLIND METHOD; STATISTICS, NONPARAMETRIC; STOMATITIS;

EID: 40949151478     PISSN: None     EISSN: 15263711     Source Type: Journal    
DOI: 10.5005/jcdp-9-3-40     Document Type: Article

References (33)

1. Petersen PE. Strengthening the prevention of oral cancer the WHO perspective. Community Dent Oral Epidemiol. 2005; 33:397-9.
2. Jemal A, Murrey T, Ward E, Samuel A, Towari RC, Ghafoor A, Feuer EJ, Thun MJ. Cancer statistics 2005. CA Cancer J Clin. 2005; 55(1):10-30.
3. World Health Organization & International Union against Cancer. Global action against cancer. Geneva: WHO, 2003.
4. Stewart BW, Kleihues P. World Cancer Report, 1st ed. International Agency for research on cancer, Lyon WHO 2003.
5. Petersen PE. The World Oral Health Report 2003: continuous improvement of oral health in the 21st century- the approach of WHO Global Oral Health Programme. Community Dent Oral Epidemiol 2003; 31(supp.1):3-24.
6. Scully C, Epstein JB. Oral health care for the cancer patient. Oral Oncol Eur J Cancer 1996; 32 B:281-292.
7. Vissink A, Jansma J, Spijkervet FKL, Burlage FR, Coppes RP. Oral sequellae of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003; 14(3):199-212.
8. Vissink A, Burlage FR, Spijkervet FKL, Jansmal J, Coppes RP. Prevention & treatment of the consequences of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003; 14(3):213-225.
9. Sonis ST. The pathophysiology of mucositis. Nature Reviews Cancer. 2004; 4: 277-84.
10. Consensus statement. Oral complications of cancer therapies. NCI Monogr. 1990; 9:3-8.
11. Sonis ST, Eilers JP, Epstein JB, Le Vaque FG, Liggett WH, Mulagha MT, Peterson DE, Rose AH, Schubert MM, Spijkervet FK, Wittes JP. Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Cancer. 1999; 85:2103-211.
12. Sutherland SE, Brownman GP. Prophylaxis of oral mucositis irradiated head and neck cancer patients: a proposed classification scheme of interventions & Meta analysis of randomized controlled trials. Int J Radiol Oncol Biol Phys.2001; 49:917-930.
13. Biswall MM, Zakaria A, Ahmad NM. Topical application of honey in the management of radiation mucositis: Apreliminary study. Support Care Cancer. 2003; 11:242-248.
14. Liza G, Ovington LG. Honey: Ancient cure or modern alternative? Wound Care newsletter. 1999 Jan;4:1-3.
15. Molan PC. The theory of honey in the management of wound. J Wound Care. 1999; 8(8):423-6.
16. Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns. 1998; 24(2):157-61.
17. Molan PC. The potential of honey promote oral wellness: Gen Dent. 2001; 49(6):584-9.
18. Cooper RA, Molan PC. The use of honey in healing a recalcitrant wound following surgical treatment of hidradentitis supportive. Eur J Clin Microbiol Inf Dis. 2001; 20:758-759.
19. Vander Weyden EA. The use of honey for the treatment of two patients with pressure ulcers. Community Nurs. 2003; 8(12):514-20.
20. Handschel J, Prott FJ, Sunderkötter C, Metze D, Meyer U, Joos U. Irradiation induces increase of adhesion molecules and accumulation of 2-integrin-expressing cell in humans. Int J Radiat Oncol Biol Phys. 1999; 45:475-481.
21. Al-Tikriti U, Martin MV, Bramley PA. A pilot study of the clinical effects of irradiation on the oral tissues. Br J Oral Maxillofac Surg. 1984; 22:77-86.
22. Bernhoft CH, Skaug N. Oral findings in irradiated edentulous patients. Int J Oral Surg.1985; 14:416.
23. Wymenga AN, van der Graaf WT, Hofstra LS, Spijkervet FK, Timens W, Timmer-Bosscha H, Sluiter WJ, van Buuren AH, Mulder NH, de Vries EG. Phase I study of transforming growth factor β3 mouthwash for prevention of chemotherapy induced mucositis. Clin Cancer Res.1999; 5(6):1363-1368.
24. Dorr W, Noack R, Spekl K, Forrell CL. Modification of oral mucositis by keratinocyte growth factor: single radiation exposure. Int Radiat Biol. 2001; 77:341-347.
25. Schonekas KG, Wagner W, Prott FJ. Amifostine a radioprotector in locally advanced head and neck tumors. Strahlenther Onko.1999; l 175 [Suppl 4]:30-33.
26. Mascarin M, Franchin G, Minatel E, Gobitti C, Talamini R, De Maria D, Trovò MG., The effect of granulocyte colony-stimulating factor on oral mucositis in head and neck cancer patients treated with hyperfractionated radiotherapy. Oral Oncol.1999; 35: 203-8.
27. Epstein JB, Stevenson-Moore P, Jackson S, Mohamed JH, Spinelli JJ. Prevention of oral mucositis in radiation therapy: a controlled study with Benzydamine hydrochloride rinse. Int J Radiat Oncol Biol Phys. 1989; 16:1571-5.
28. Okuno SI, Foote RL, Loprinzi CL, Gulavita S, Sloan JA, Earle J, Novotny PJ, Burk M, Frank AR. A randomized trail of a nonabsorbable antibiotic lozenge given to alleviate radiation-induced mucositis. Cancer. 1997; 79(11):2193-9.
29. Qiu PY, Ding HB, Tang YK, Xu RJ. Determination of chemical composition of commercial honey by near-infrared spectroscopy. J Argic Food Chem.1999; 47:2760-2765.
30. Vardi A, Barzilay Z, Linder N, Cohen HA, Paret G, Barzilai A. Local application of honey for treatment of neonated postoperative wound infection. Acta Paediatr. 1998; 87(4): 429-32.
31. Al-Waili NS, Saloom KY. Effect of topical honey on post-operative wound infections due to gram positive and gram negative bacteria following caesarean sections and hysterectomies. Eur J Med Res.1999; 4(3):126-30.
32. Abuharfeil N, Al Oran R, Abo-Shehada M. The effect of bee honey on the proliferative activity of phagocytes. Food Argic Immunol. 1999; 11:169-77.
33. Tonks AJ, Cooper RA, Jones KP, Blair S, Parton J, Tonks A. Honey stimulates inflammatory cytokine production from monocyte. Cytokine. 2003 Mar 7; 21(5):242-7.