Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 308, Issue 9, 2015, Pages H1039-H1050

  Reho, John J ^a   Zheng, Xiaoxu ^a   Asico, Laureano D ^a   Fisher, Steven A ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Endotoxemia; Mesenteric artery; Myosin phosphatase

Indexed keywords

INOSINATE DEHYDROGENASE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; ISOPROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; MYOSIN PHOSPHATASE; NITRIC OXIDE; PHENYLEPHRINE; PHOSPHATASE; UNCLASSIFIED DRUG; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOENZYME; LIPOPOLYSACCHARIDE, ESCHERICHIA COLI 0111 B4; MUSCLE PROTEIN; MYOSIN LIGHT CHAIN KINASE; MYOSIN LIGHT CHAIN PHOSPHATASE; MYPT1 PROTEIN, MOUSE; NOS2 PROTEIN, MOUSE; PHOSPHOPROTEIN; PPP1R14A PROTEIN, MOUSE; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ADULT; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR PARAMETERS; COMPARATIVE STUDY; DOWN REGULATION; EXON; GENE DELETION; GENE EXPRESSION; INDEL MUTATION; LOXP SITE; MALE; MEAN ARTERIAL PRESSURE; MOUSE; MUSCLE ATROPHY; NITRIC OXIDE VASODILATOR RESERVE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RNA SPLICING; SEPSIS; SIGNAL TRANSDUCTION; VASODILATATION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; KNOCKOUT MOUSE; MESENTERIC ARTERY; METABOLISM; MICROCIRCULATION; PATHOPHYSIOLOGY; PHENOTYPE; TIME; VASCULAR SMOOTH MUSCLE;

ANIMALS; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASE TYPE I; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENOTYPE; ISOENZYMES; LIPOPOLYSACCHARIDES; MALE; MESENTERIC ARTERIES; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROCIRCULATION; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MUSCULAR ATROPHY; MYOSIN-LIGHT-CHAIN KINASE; MYOSIN-LIGHT-CHAIN PHOSPHATASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATION-REDUCTION; PHENOTYPE; PHOSPHOPROTEINS; RNA, MESSENGER; SEPSIS; SIGNAL TRANSDUCTION; TIME FACTORS; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 84929688878     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00912.2014     Document Type: Article

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