Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse

Circulation

Volumn 126, Issue 3, 2012, Pages 287-295

  Rudyk, Olena ^a   Prysyazhna, Oleksandra ^a   Burgoyne, Joseph R ^a   Eaton, Philip ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

blood pressure; nitroglycerin; oxidative stress; signal transduction; vascular response

Indexed keywords

AURANOFIN; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE 1ALPHA; CYSTEINE; DISULFIDE; GLYCERYL TRINITRATE; SERINE; THIOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL; CONTROLLED STUDY; DIMERIZATION; DRUG MEGADOSE; ENZYME METABOLISM; GENE TARGETING; GENOTYPE; HYPOTENSION; IN VIVO STUDY; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; OXIDATION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TELEMETRY; VASCULAR RESISTANCE; VASODILATATION; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; AORTA; BLOOD PRESSURE; CELLS, CULTURED; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DIMERIZATION; DISULFIDES; GENE KNOCK-IN TECHNIQUES; HYPERTENSION; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUSCLE, SMOOTH, VASCULAR; NITROGLYCERIN; OXIDATION-REDUCTION; RATS; SIGNAL TRANSDUCTION; SULFHYDRYL COMPOUNDS; TELEMETRY; VASODILATION; VASODILATOR AGENTS;

EID: 84863981193     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.101287     Document Type: Article

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