Smooth muscle-selective CPI-17 expression increases vascular smooth muscle contraction and blood pressure

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 305, Issue 1, 2013, Pages

  Su, Wen ^a   Xie, Zhongwen ^a   Liu, Shu ^a   Calderon, Lindsay E ^a   Guo, Zhenheng ^a   Gong, Ming C ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Hypercontractility; Phosphatase inhibitory protein; Protein kinase C potentiated myosin phosphatase inhibitor of 17 kilodaltons

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANGIOTENSIN II; CALCIUM; MUSCLE PROTEIN; MYOSIN LIGHT CHAIN; NORADRENALIN; PHENYLEPHRINE; POTASSIUM; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C POTENTIATED MYOSIN PHOSPHATASE INHIBITOR 17 KDA; RHO KINASE; RHO KINASE 2; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY PERFUSION; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; EMBRYO; EXPERIMENTAL MODEL; MALE; MESENTERIC ARTERY; MORPHOMETRICS; MOUSE; MUSCLE ISOMETRIC CONTRACTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE CONTRACTION; TELEMETRY; UPREGULATION; VASCULAR SMOOTH MUSCLE;

HYPERCONTRACTILITY; PHOSPHATASE INHIBITORY PROTEIN; PROTEIN KINASE C-POTENTIATED MYOSIN PHOSPHATASE INHIBITOR OF 17 KILODALTONS;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; CALCIUM; ISOMETRIC CONTRACTION; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; PHENYLEPHRINE; PHOSPHOPROTEINS; POTASSIUM; SEROTONIN; TRANSCRIPTION, GENETIC; UP-REGULATION; VASOCONSTRICTOR AGENTS;

EID: 84879593386     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00597.2012     Document Type: Article

References (40)

1. Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, Wright AD, Turner RC, Holman RR. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. Br Med J 321: 412-419, 2000.
2. Chang L, Villacorta L, Zhang J, Garcia-Barrio MT, Yang K, Hamblin M, Whitesall SE, D'Alecy LG, Chen YE. Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension. Circulation 119: 2161-2169, 2009.
3. Chang S, Hypolite JA, Disanto ME, Changolkar A, Wein AJ, Chacko S. Increased basal phosphorylation of detrusor smooth muscle myosin in alloxan-induced diabetic rabbit is mediated by upregulation of Rho-kinase beta and CPI-17. Am J Physiol Renal Physiol 290: F650-F656, 2006.
4. Collins R, Peto R, MacMahon S, Hebert P, Fiebach NH, Eberlein KA, Godwin J, Qizilbash N, Taylor JO, Hennekens CH. Blood pressure, stroke, and coronary heart disease. Part 2. Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 335: 827-838, 1990.
5. Crowley SD, Gurley SB, Oliverio MI, Pazmino AK, Griffiths R, Flannery PJ, Spurney RF, Kim HS, Smithies O, Le TH, Coffman TM. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest 115: 1092-1099, 2005.
6. Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T. Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle. Circ Res 100: 121-129, 2007.
7. Eto M. Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors. J Biol Chem 284: 35273-35277, 2009.
8. Eto M, Senba S, Morita F, Yazawa M. Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle. FEBS Lett 410: 356-360, 1997.
9. Gong MC, Cohen P, Kitazawa T, Ikebe M, Masuo M, Somlyo AP, Somlyo AV. Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle. J Biol Chem 267: 14662-14668, 1992.
10. Guilluy C, Bregeon J, Toumaniantz G, Rolli-Derkinderen M, Retailleau K, Loufrani L, Henrion D, Scalbert E, Bril A, Torres RM, Offermanns S, Pacaud P, Loirand G. The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat Med 16: 183-190, 2010.
11. Guo Z, Su W, Ma Z, Smith GM, Gong MC. Ca2+-independent phospholipase A2 is required for agonist-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem 278: 1856-1863, 2003.
12. Guyton AC, Coleman TG, Cowley AV Jr, Scheel KW, Manning RD Jr, Norman RA Jr. Arterial pressure regulation Overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med 52: 584-594, 1972.
13. Halabi CM, Beyer AM, de Lange WJ, Keen HL, Baumbach GL, Faraci FM, Sigmund CD. Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab 7: 215-226, 2008.
14. Horiuti K. Mechanism of contracture on cooling of caffeine-treated frog skeletal muscle fibres. J Physiol 398: 131-148, 1988.
15. Kim JI, Young GD, Jin L, Somlyo AV, Eto M. Expression of CPI-17 in smooth muscle during embryonic development and in neointimal lesion formation. Histochem Cell Biol 132: 191-198, 2009.
16. Kitazawa T, Eto M, Woodsome TP, Brautigan DL. Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J Biol Chem 275: 9897-9900, 2000.
17. Kitazawa T, Eto M, Woodsome TP, Khalequzzaman M. Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle. J Physiol 546: 879-889, 2003.
18. Kitazawa T, Kitazawa K. Size-dependent heterogeneity of contractile Ca2+ sensitization in rat arterial smooth muscle. J Physiol 590: 5401-5423, 2012.
19. Kitazawa T, Kobayashi S, Horiuti K, Somlyo AV, Somlyo AP. Receptor-coupled, permeabilized smooth muscle. Role of the phosphatidylinositol cascade, G-proteins, and modulation of the contractile response to Ca2+. J Biol Chem 264: 5339-5342, 1989.
20. Kitazawa T, Polzin AN, Eto M. CPI-17-deficient smooth muscle of chicken. J Physiol 557: 515-528, 2004.
21. Kitazawa T, Takizawa N, Ikebe M, Eto M. Reconstitution of protein kinase C-induced contractile Ca2+ sensitization in triton X-100-demembranated rabbit arterial smooth muscle. J Physiol 520: 139-152, 1999.
22. Koyama M, Ito M, Feng J, Seko T, Shiraki K, Takase K, Hartshorne DJ, Nakano T. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. FEBS Lett 475: 197-200, 2000.
23. Li L, Eto M, Lee MR, Morita F, Yazawa M, Kitazawa T. Possible involvement of the novel CPI-17 protein in protein kinase C signal transduction of rabbit arterial smooth muscle. J Physiol 508: 871-881, 1998.
24. Lindholm LH. The outcome of STOP-Hypertension-2 in relation to the 1999 WHO/ISH hypertension guidelines. Blood Press Suppl 2: 21-24, 2000.
25. Liu S, Xie Z, Zhao Q, Pang H, Turk J, Calderon L, Su W, Zhao G, Xu H, Gong MC, Guo Z. Smooth muscle-specific expression of calciumindependent phospholipase A2beta (iPLA2beta) participates in the initiation and early progression of vascular inflammation and neointima formation. J Biol Chem 287: 24739-24753, 2012.
26. MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, Abbott R, Godwin J, Dyer A, Stamler J. Blood pressure, stroke, and coronary heart disease. Part 1. Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 335: 765-774, 1990.
27. Mattes A, Witte K, Hohmann W, Lemmer B. PHARMFIT-a nonlinear fitting program for pharmacology. Chronobiol Int 8: 460-476, 1991.
28. Michael SK, Surks HK, Wang Y, Zhu Y, Blanton R, Jamnongjit M, Aronovitz M, Baur W, Ohtani K, Wilkerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME. High blood pressure arising from a defect in vascular function. Proc Natl Acad Sci USA 105: 6702-6707, 2008.
29. Ohama T, Hori M, Momotani E, Iwakura Y, Guo F, Kishi H, Kobayashi S, Ozaki H. Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-α and causes motility disorders. Am J Physiol Gastrointest Liver Physiol 292: G1429-G1438, 2007.
30. Pang H, Guo Z, Su W, Xie Z, Eto M, Gong MC. RhoA-Rho kinase pathway mediates thrombin-and U-46619-induced phosphorylation of a myosin phosphatase inhibitor, CPI-17, in vascular smooth muscle cells. Am J Physiol Cell Physiol 289: C352-C360, 2005.
31. Pang H, Guo Z, Xie Z, Su W, Gong MC. Divergent kinase signaling mediates agonist-induced phosphorylation of phosphatase inhibitory proteins PHI-1 and CPI-17 in vascular smooth muscle cells. Am J Physiol Cell Physiol 290: C892-C899, 2006.
32. Persechini A, Kamm KE, Stull JT. Different phosphorylated forms of myosin in contracting tracheal smooth muscle. J Biol Chem 261: 6293-6299, 1986.
33. Sakai H, Chiba Y, Misawa M. Augmentation of endothelin-1-induced phosphorylation of CPI-17 and myosin light chain in bronchial smooth muscle from airway hyperresponsive rats. Biol Pharm Bull 29: 1897-1899, 2006.
34. Senba S, Eto M, Yazawa M. Identification of trimeric myosin phosphatase (PP1M) as a target for a novel PKC-potentiated protein phosphatase-1 inhibitory protein (CPI17) in porcine aorta smooth muscle. J Biochem (Tokyo) 125: 354-362, 1999.
35. Stevenson AS, Matthew JD, Eto M, Luo S, Somlyo AP, Somlyo AV. Uncoupling of GPCR and RhoA-induced Ca2+-sensitization of chicken amnion smooth muscle lacking CPI-17. FEBS Lett 578: 73-79, 2004.
36. Su W, Guo Z, Randall DC, Cassis L, Brown DR, Gong MC. Hypertension and disrupted blood pressure circadian rhythm in type 2 diabetic db/db mice. Am J Physiol Heart Circ Physiol 295: H1634-H1641, 2008.
37. Wirth A, Benyo Z, Lukasova M, Leutgeb B, Wettschureck N, Gorbey S, Orsy P, Horvath B, Maser-Gluth C, Greiner E, Lemmer B, Schutz G, Gutkind JS, Offermanns S. G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med 14: 64-68, 2008.
38. Woodsome TP, Eto M, Everett A, Brautigan DL, Kitazawa T. Expression of CPI-17 and myosin phosphatase correlates with Ca(2+) sensitivity of protein kinase C-induced contraction in rabbit smooth muscle. J Physiol 535: 553-564, 2001.
39. Xie Z, Gong MC, Su W, Turk J, Guo Z. Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional upregulation of regulator of g-protein signaling-2 in vascular smooth muscle cells. J Biol Chem 282: 25278-25289, 2007.
40. Xie Z, Su W, Guo Z, Pang H, Post SR, Gong MC. Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells. Cardiovasc Res 69: 491-501, 2006.