Irisin, a novel myokine, regulates glucose uptake in skeletal muscle cells via AMPK

Molecular Endocrinology

Volumn 29, Issue 6, 2015, Pages 873-881

  Lee, Hye Jeong ^a   Lee, Jung Ok ^a   Kim, Nami ^a   Kim, Joong Kwan ^a   Kim, Hyung Ip ^a   Lee, Yong Woo ^a   Kim, Su Jin ^a   Choi, Jong Il ^b   Oh, Yoonji ^c   Kim, Jeong Hyun ^d   Hwang, Suyeon ^e   Park, Sun Hwa ^a   Kim, Hyeon Soo ^a  

^a Korea University College of Medicine   (South Korea)

^b Korea University Ansan Hospital   (South Korea)

^c Korea University   (South Korea)

^d Duksung Women's University   (South Korea)

^e UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CALCIUM; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IRISIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; FIBRONECTIN; GLUCOSE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE; COLORIMETRY; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE REPRESSION; GENE SILENCING; GENE TRANSLOCATION; GLUCOSE TRANSPORT; HYPOGLYCEMIA; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; ENZYME ACTIVATION; FIBRONECTINS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; MUSCLE, SKELETAL; MYOBLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN TRANSPORT; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84929648291     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/me.2014-1353     Document Type: Article

References (44)

1. Hardie DG, Carling D. The AMP-activated protein kinase–fuel gauge of the mammalian cell? Eur J Biochem. 1997;246:259–273.
2. Sakamoto K, McCarthy A, Smith D, et al. Deficiency of LK1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J. 2005;24:1810-1820.
3. Koh HJ, Arnolds DE, Fujii N, et al. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol. 2006;26:8217-8227.
4. Woods A, Dickerson K, Heath R, et al. Ca2+/calmodulin-dependent protein kinase kinase-/3 acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2005;2:21-33.
5. Hawley SA, Pan DA, Mustard KJ, et al. Calmodulin-dependent protein kinase kinase-/3 is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2005;2:9-19.
6. Hayashi T, Hirshman MF, Kurth EJ, Winder WW, Goodyear LJ. Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes. 1998; 47:1369-1373.
7. Mu J, Brozinick JT Jr, Valladares O, Bucan M, Birnbaum MJ. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell. 2001;7: 1085-1094.
8. Tsao TS, Burcelin R, Katz EB, Huang L, Charron MJ. Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle. Diabetes. 1996;45:28-36.
9. Tsao TS, Li J, Chang KS, et al. Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity. FASEB J. 2001;15:958-969.
10. Rossetti L, Stenbit AE, Chen W, et al. Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene. J Clinic Invest. 1997;100:1831-1839.
11. Shan T, Liang X, Bi P, Kuang S. Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1a-Fndc5 pathway in muscle. FASEB J. 2013;27:1981-1989.
12. Pedersen BK. Muscles and their myokines. J Exp Bio. 2011;214: 337-346.
13. Pedersen BK, Akerstrom TC, Nielsen AR, Fischer CP. Role of myokines in exercise and metabolism. J Appl Physiol. 2007;103,1093-1098.
14. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev. 2008;88:1379-1406.
15. Nishimura T, Nakatake Y, Konishi M, Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta. 2000;1492(1):203-206.
16. Oshima Y, Ouchi N, Sato K, Izumiya Y, Pimentel DR, Walsh K. Follistatin-like 1 is an Akt-regulated cardio protective factor that is secreted by the heart. Circulation. 2008;117:3099-3108.
17. Broholm C, Mortensen OH, Nielsen S, et al. Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle. J Physiol. 2008;586:2195-2201.
18. Haugen F, Norheim F, Lian H, et al. IL-7 is expressed and secreted by human skeletal muscle cells. Am J Physiol Cell Physiol. 2010; 298:C807-C816.
19. Grabstein KH, Eisenman J, Shanebeck K, et al. Cloning of a T cell growth factor that interacts with the /3 chain of the interleukin-2 receptor. Science. 1994;264:965-968.
20. Nishizawa H, Matsuda M, Yamada Y, et al. Musclin, a novel skeletal muscle-derived secretory factor. J Biol Chem. 2004;279: 19391-19395.
21. Boström P, Wu J, Jedrychowski MP, et al. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463-468.
22. Henriksen T, Green C, Pedersen BK. Myokines in myogenesis and health. Recent Pat Biotechnol. 2012;6:167-171.
23. Pedersen L, Hojman P. Muscle-to-organ cross talk mediated by myokines. Adipocyte. 2012;1:164-167.
24. Wang S, Mu J, Fan Z, et al. Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla. Stem Cell Res. 2012;8:346-356.
25. Ouchi N, Oshima Y, Ohashi K, et al. Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism. J Biol Chem. 2008;283:32802-32811.
26. Zhang Y, Li R, Meng Y, et al. Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes. 2014;63:514-525.
27. Hofmann T, Elbelt U, Stengel A. Irisin as a muscle derived hormone stimulating thermogenesis-a critical update. Peptides. 2014;54: 89-100.
28. Moreno-Navarrete JM, Ortega F, Serrano M, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab. 2013;98:E769-E778.
29. Shafique E, Choy WC, Liu Y, et al. Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK. Aging (Albany NY). 2013;5(7):515-530.
30. Sandström ME, Zhang SJ, Bruton J, et al. Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle. J Physiol. 2006;575:251-262.
31. Lanna A Henson SM, Escors D, Akbar AN. The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat Immunol. 2014;15(10):965-972.
32. Hsu YC, Meng X, Ou L, Ip MM. Activation of the AMP-activated protein kinase-p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells. Cell Signal. 2010;22(4):590-599.
33. Niu W, Huang C, Nawaz Z, et al. Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis. J Biol Chem. 2003;278(20):17953-17962.
34. Somwar R, Kim DY, Sweeney G, et al. GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase. Biochem J. 2001;359(pt 3):639-649.
35. Gouni-Berthold I, Berthold HK, Huh JY, et al. Effects of lipid-lowering drugs on irisin in human subjects in vivo and in human skeletal muscle cells ex vivo. PLoS One. 2013;8:e72858.
36. Park KH, Zaichenko L, Brinkoetter M, et al. Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab. 2013;98:4899-4907.
37. Zhang HJ, Zhang XF, Ma ZM, et al. Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. J Hepatol. 2013;59:557-562.
38. Vamvini MT, Aronis KN, Panagiotou G, et al. Irisin mRNA And circulating levels in relation to other myokines in healthy and morbidly obese humans. Eur J Endocrinol. 2013;169:829-834.
39. Zierler K. Does insulin-induced increase in the amount of plasma membrane GLUTs quantitatively account for insulin-induced increase in glucose uptake? Diabetologia. 1998;41:724-730.
40. Carey AL, Steinberg GR, Macaulay SL, et al. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes. 2006;55(10):2688-2697.
41. Lee WJ, Song KH, Koh EH, et al. a-Lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun. 2005;8:332(3):885-891.
42. Yang M, Chen P, Jin H, et al. Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus — correlation withpancreatic/3-cell function. DiabetolMetab Syndr. 2014;6:133.
43. Dun SL, Lyu RM, Chen YH, Chang JK, Luo JJ, Dun NJ. Irisin-immunoreactivity in neural and non-neural cells of the rodent. Neu-roscience. 2013;240:155-162.
44. Schumacher MA, Chinnam N, Ohashi T, Shah RS, Erickson H. Structure of irisin reveals a novel intersubunit /3-sheet fibronectin (FNIII) dimer: implications for receptor activation. J Biol Chem. 2013;288:33738-33744.