Circulating levels of irisin in middle-Aged first-degree relatives of type 2 diabetes mellitus-correlation with pancreatic β-cell function

Diabetology and Metabolic Syndrome

Volumn 6, Issue 1, 2014, Pages

  Yang, Meili ^a,b   Chen, Peihong ^a   Jin, Hua ^a   Xie, Xinmiao ^a   Gao, Ting ^a,b   Yang, Lili ^a   Yu, Xuemei ^a,b  

^a Fengxian Central Hospital   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

First degree relatives; Irisin; Pancreatic cell; Type 2 diabetes mellitus

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; INSULIN; IRISIN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTHROPOMETRY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY COMPOSITION; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTROCHEMISTRY; ENERGY METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FAT MASS; FATTY ACID METABOLISM; FEMALE; FIRST-DEGREE RELATIVE; GLOMERULUS FILTRATION RATE; GLUCOSE METABOLISM; HORMONE BLOOD LEVEL; HUMAN; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MUSCLE MASS; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PHYSICAL ACTIVITY; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84989166038     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-6-133     Document Type: Article

References (38)

1. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, et al: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010, 42:579-589.
2. Perseghin G, Ghosh S, Gerow K, Shulman GI: Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study. Diabetes 1997, 46:1001-1009.
3. Meigs JB, Cupples LA, Wilson PW: Parental transmission of type 2 diabetes: The Framingham Offspring Study. Diabetes 2000, 49:2201-2207.
4. Alibegovic AC, Højbjerre L, Sonne MP, van Hall G, Stallknecht B, Dela F, Vaag A: Impact of 9 days of bed rest on hepatic and peripheral insulin action, insulin secretion, and whole-body lipolysis in healthy young male offspring of patients with type 2 diabetes. Diabetes 2009, 58:2749-2756.
5. Vaag A, Henriksen JE, Beck-Nielsen H: Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1992, 89:782-788.
6. Pedersen BK, Steensberg A, Fischer C, Keller C, Keller P, Plomgaard P, Febbraio M, Saltin B: Searching for the exercise factor: is IL-6 a candidate? J Muscle Res Cell Motil 2003, 24:113-119.
7. Bortoluzzi S, Scannapieco P, Cestaro A, Danieli GA, Schiaffino S: Computational reconstruction of the human skeletal muscle secretome. Proteins 2006, 62:776-792.
8. Henningsen J, Rigbolt KT, Blagoev B, Pedersen BK, Kratchmarova I: Dynamics of the skeletal muscle secretome during myoblast differentiation. Mol Cell Proteomics 2010, 9:2482-2496.
9. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hojlund K, Gygi SP, Spiegelman BM: A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012, 481:463-468.
10. Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, Mantzoros CS: FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012, 61:1725-1738.
11. Zhang HJ, Zhang XF, Ma ZM, Pan LL, Chen Z, Han HW, Han CK, Zhuang XJ, Lu Y, Li XJ, Yang SY, Li XY: Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. J Hepatol 2013, 59:557-562.
12. Choi YK, Kim MK, Bae KH, Seo HA, Jeong JY, Lee WK, Kim JG, Lee IK, Park KG: Serum irisin levels in new-onset type 2 diabetes. Diabetes Res Clin Pract 2013, 100:96-101.
13. Liu JJ, Wong MD, Toy WC, Tan CS, Liu S, Ng XW, Tavintharan S, Sum CF, Lim SC: Lower circulating irisin is associated with type 2 diabetes mellitus. J Diabetes Complications 2013, 27:365-369.
14. Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, Ricart W, Fernández-Real JM: Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab 2013, 98:E769-E778.
15. Timmons JA, Baar K, Davidsen PK, Atherton PJ: Is irisin a human exercise gene? Nature 2012, 488:E9-E11.
16. Boström PA, Graham EL, Georgiadi A, Ma X: Impact of exercise on muscle and nonmuscle organs. IUBMB Life 2013, 65:845-850.
17. Colberg SR: Physical activity, insulin action, and diabetes prevention and control. Curr Diabetes Rev 2007, 3:176-184.
18. Hawley JA, Lessard SJ: Exercise training-induced improvements in insulin action. Acta Physiol (Oxf ) 2008, 192:127-135.
19. Hoene M, Lehmann R, Hennige AM, Pohl AK, Häring HU, Schleicher ED, Weigert C: Acute regulation of metabolic genes and insulin receptor substrates in the liver of mice by one single bout of treadmill exercise. J Physiol 2009, 587:241-252.
20. Pold R, Jensen LS, Jessen N, Buhl ES, Schmitz O, Flyvbjerg A, Fujii N, Goodyear LJ, Gotfredsen CF, Brand CL, Lund S: Long-Term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes 2005, 54:928-934.
21. Calegari VC, Zoppi CC, Rezende LF, Silveira LR, Carneiro EM, Boschero AC: Endurance training activates AMP-Activated protein kinase, increases expression of uncoupling protein 2 and reduces insulin secretion from rat pancreatic islets. J Endocrinol 2011, 208:257-264.
22. Donath MY, Shoelson SE: Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011, 11:98-107.
23. Dinarello CA, Donath MY, Mandrup-Poulsen T: Role of IL-1betain type 2 diabetes. Curr Opin Endocrinol Diabetes Obes 2010, 17:314-321.
24. Zhang Y, Li R, Meng Y, Li S, Donelan W, Zhao Y, Qi L, Zhang M, Wang X, Cui T, Yang LJ, Tang D: Irisin stimulates browning of white adipocytes through mitogen-Activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes 2014, 63:514-525.
25. Swick AG, Orena S, O'Connor A: Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass. Metabolism 2013, 62:1070-1073.
26. Roberts MD, Bayless DS, Company JM, Jenkins NT, Padilla J, Childs TE, Martin JS, Dalbo VJ, Booth FW, Rector RS, Laughlin MH: Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats. Metabolism 2013, 62:1052-1056.
27. Polyzos SA, Kountouras J, Shields K, Mantzoros CS: Irisin: A renaissance in metabolism? Metabolism 2013, 62:1037-1044.
28. Villarroya F: Irisin, turning up the heat. Cell Metab 2012, 15:277-278.
29. Kelly DP: Irisin, Light My Fire. Science 2012, 336:42-43.
30. Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM: Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012, 150:366-376.
31. Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF: Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity-correlation with body mass index. Peptides 2013, 39:125-130.
32. Al-Daghri NM, Alkharfy KM, Rahman S, Amer OE, Vinodson B, Sabico S, Piya MK, Harte AL, McTernan PG, Alokail MS, Chrousos GP: Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects. Eur J Clin Invest 2013, 44:119-124.
33. Guo F, Moellering DR, Garvey WT: Use of HbA1c for diagnoses of diabetes and prediabetes: comparison with diagnoses based on fasting and 2-Hr glucose values and effects of gender, race, and age. Metab Syndr Relat Disord 2014, 12:258-268.
34. Wen MS, Wang CY, Lin SL, Hung KC: Decrease in irisin in patients with chronic kidney disease. PLoS One 2013, 8:e64025.
35. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ: Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potentialrole of PGC1 and NRF1. Proc Natl Acad Sci U S A 2003, 100:8466-8471.
36. Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, Jung R, Wisløff U, Tjønna AE, Raastad T, Hallén J, Norheim F, Drevon CA, Romacho T, Eckardt K, Eckel J: Evidence against a beneficial effect of irisin in humans. PLoS One 2013, 8:e73680.
37. Erickson HP: Irisin and FNDC5 in retrospect. Adipocyte 2013, 2:289-293.
38. Hofmann T, Elbelt U, Ahnis A, Kobelt P, Rose M, Stengel A: Irisin levels are not affected by physical activity in patients with anorexia nervosa. Front Endocrinol (Lausanne) 2014, 4:202.