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Volumn 6, Issue 6, 2015, Pages 3550-3555

Enantioselective synthesis of bicyclo[3.n.1]alkanes by chiral phosphoric acid-catalyzed desymmetrizing Michael cyclizations

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIZATION; ENANTIOSELECTIVITY; PHOSPHORIC ACID;

EID: 84929600603     PISSN: 20416520     EISSN: 20416539     Source Type: Journal    
DOI: 10.1039/c5sc00753d     Document Type: Article
Times cited : (29)

References (74)
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    • The relative and absolute stereochemistries of the products described herein were assigned by analogy to those of products 2d, 3a, 6e, and 6f, which were determined by X-ray crystallography. See the ESI.† Although the substrate and phosphoric acid 4b are poorly soluble in cyclohexane at room temperature, the reaction mixtures become homogeneous upon heating to 50 °C For catalytic enantioselective conjugate additions of carbon-centered nucleophiles to 2-alkenylazaarenes, see
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    • However, the precise manner in which the catalyst 4b favors Si-face attack is not readily explained at the present time
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    • See ESI for full details. This experiment was conducted in toluene rather than cyclohexane to ensure complete homogeneity of the reaction mixture
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.