Glucagon and lipid signaling in the hypothalamus

Mammalian Genome

Volumn 25, Issue 9-10, 2014, Pages 434-441

  LaPierre, Mary P ^a,b   Abraham, Mona A ^a,b   Filippi, Beatrice M ^a   Yue, Jessica T Y ^a   Lam, Tony K T ^a,b,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MaRS Centre   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; COENZYME A; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCAGON; GLUCAGON RECEPTOR; LIPID; LONG CHAIN FATTY ACID; PROTEIN KINASE C DELTA;

ARCUATE NUCLEUS; DIABETES MELLITUS; FAT INTAKE; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; HYPOTHALAMUS; NONHUMAN; OBESITY; REVIEW; ANIMAL; LIPID DIET; LIPID METABOLISM; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; DIET, HIGH-FAT; GLUCAGON; HUMANS; HYPOTHALAMUS; LIPID METABOLISM; SIGNAL TRANSDUCTION;

EID: 84929506500     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-014-9510-6     Document Type: Review

References (67)

1. Abraham MA, Yue JT, LaPierre MP, Rutter GA, Light PE, Filippi BM, Lam TK (2014) Hypothalamic glucagon signals through the KATP channels to regulate glucose production. Mol Metab 3:202–208
2. Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ (2001) Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 291:2613–2616
3. Acosta-Martínez M, Levine JE (2007) Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats. Am J Physiol Endocrinol Metab 292:E1801–E1807
4. Agarwala GC, Bapat SK (1977) Effect of centrally administered glucagon on blood glucose levels in dogs. Indian J Med Res 66:323–330
5. Agarwala GC, Mishra R, Jaiswal G, Bapat V (1989) Effect of centrally administered glucagon on liver glycogen & enzymes in anaesthetised dogs. Indian J Med Res 90:372–378
6. Amatruda JM, Livingston JN (2003) Glucagon. In: Porte D, Sherwin RS, Baron A, Ellenberg M, Rifkin H (eds) Ellenberg and Rifkin’s diabetes mellitus, 6th edn. McGraw-Hill, Ann Arbor, pp 97–115
7. Béguin P, Nagashima K, Nishimura M, Gonoi T, Seino S (1999) PKA-mediated phosphorylation of the human K(ATP) channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation. EMBO J 18:4722–4732
8. Belgardt BF, Okamura T, Brüning JC (2009) Hormone and glucose signalling in POMC and AgRP neurons. J Physiol 587:5305–5314
9. Bomboy JD, Lewis SB, Lacy WW, Sinclair-Smith BC, Liljenquist JE (1977) Transient stimulatory effect of sustained hyperglucagonemia on splanchnic glucose production in normal and diabetic man. Diabetes 26:4–177
10. Brand CL, Rolin B, Jørgensen PN, Svendsen I, Kristensen JS, Holst JJ (1994) Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats. Diabetologia 37:985–993
11. Choi CS, Savage DB, Abu-Elheiga L, Liu Z-X, Kim S, Kulkarni A, Distefano A, Hwang Y-J, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI (2007) Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci USA 104:16480–16485
12. Damm E, Buech TRH, Gudermann T, Breit A (2012) Melanocortin-induced PKA activation inhibits AMPK activity via ERK-1/2 and LKB-1 in hypothalamic GT1-7 cells. Mol Endocrinol 26:643–654
13. Dogrukol-Ak D, Tore F, Tuncel N (2004) Passage of VIP/PACAP/secretin family across the blood-brain barrier: therapeutic effects. Curr Pharm Des 10:1325–1340
14. Eigler N, Saccà L, Sherwin RS (1979) Synergistic interactions of physiologic increments of glucagon, epinephrine, and cortisol in the dog: a model for stress-induced hyperglycemia. J Clin Invest 63:114–123
15. Felig P, Wahren J, Hendler R (1976) Influence of physiologic hyperglucagonemia on basal and insulin-inhibited splanchnic glucose output in normal man. J Clin Invest 58:761–765
16. Filippi BM, Yang CS, Tang C, Lam TKT (2012) Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production. Cell Metab 16:500–510
17. Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, Charron MJ (2003) Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci USA 100:1438–1443
18. Gerich JE (1981) Physiology of glucagon. Int Rev Physiol 24:243–275
19. Hamilton JA, Brunaldi K (2007) A model for fatty acid transport into the brain. J Mol Neurosci 33:12–17
20. Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE, Cooney GJ (2010) Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metab 11:70–76
21. Honda K, Kamisoyama H, Saito N, Kurose Y, Sugahara K, Hasegawa S (2007) Central administration of glucagon suppresses food intake in chicks. Neurosci Lett 416:198–201
22. Honda K, Kamisoyama H, Uemura T, Yanagi T, Saito N, Kurose Y, Sugahara K, Katoh K, Hasegawa S (2012) The mechanism underlying the central glucagon-induced hyperglycemia and anorexia in chicks. Comp Biochem Physiol A: Mol Integr Physiol 163:260–264
23. Hoosein NM, Gurd RS (1984) Identification of glucagon receptors in rat brain. Proc Natl Acad Sci USA 81:4368–4372
24. Inokuchi A, Oomura Y, Shimizu N, Yamamoto T (1986) Central action of glucagon in rat hypothalamus. Am J Physiol 250:R120–R126
25. Jiang G, Zhang BB (2003) Glucagon and regulation of glucose metabolism. Am J Physiol Endocrinol Metab 284:E671–E678
26. Johnson DG, Goebel CU, Hruby VJ, Bregman MD, Trivedi D (1982) Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist. Science 215:1115–1116
27. Kahn BB, Alquier T, Carling D, Hardie DG (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1:15–25
28. Kishore P, Boucai L, Zhang K, Li W, Koppaka S, Kehlenbrink S, Schiwek A, Esterson YB, Mehta D, Bursheh S, Su Y, Gutierrez-Juarez R, Muzumdar R, Schwartz GJ, Hawkins M (2011) Activation of K(ATP) channels suppresses glucose production in humans. J Clin Invest 121:4916–4920
29. Kong D, Vong L, Parton LE, Ye C, Tong Q, Hu X, Choi B, Brüning JC, Lowell BB (2010) Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab 12:545–552
30. Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley Ma, Ashcroft FM, Brüning JC (2007) Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 5:438–449
31. Kurose Y, Kamisoyama H, Honda K, Azuma Y, Sugahara K, Hasegawa S, Kobayashi S (2009) Effects of central administration of glucagon on feed intake and endocrine responses in sheep. Anim Sci J 80:686–690
32. Lam TK (2010) Neuronal regulation of homeostasis by nutrient sensing. Nat Med 16:392–395
33. Lam TK, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, Schwartz GJ, Rossetti L (2005) Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 11:320–327
34. Le Foll C, Irani BG, Magnan C, Dunn-Meynell AA, Levin BE (2009) Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing. Am J Physiol Regul Integr Comp Physiol 297:R655–R664
35. Le Foll C, Dunn-Meynell AA, Musatov S, Magnan C, Levin BE (2013) FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice. Diabetes 62:2709–2716
36. Light PE, Bladen C, Winkfein RJ, Walsh MP, French RJ (2000) Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels. Proc Natl Acad Sci USA 97:9058–9063
37. López M, Varela L, Vazquez MJ, Rodriguez-Cuenca S, Gonzalez CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martinez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Dieguez C, Vidal-Puig A (2010) Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med 16:1001–1008
38. Marubashi S, Tominaga M, Katagiri T, Yamatani K, Yawata Y, Hara M, Sasaki H (1985) Hyperglycaemic effect of glucagon administered intracerebroventricularly in the rat. Acta Endocrinol (Copenh) 108:6–10
39. McGarry JD (1992) What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258:766–770
40. Mighiu PI, Yue JT, Filippi BM, Abraham MA, Chari M, Lam CK, Yang CS, Christian NR, Charron MJ, Lam TK (2013) Hypothalamic glucagon signaling inhibits hepatic glucose production. Nat Med 19:766–772
41. Minokoshi Y, Alquier T, Furukawa N, Kim Y-B, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428:569–574
42. Mitchell RW, Edmundson CL, Miller DW, Hatch GM (2009) On the mechanism of oleate transport across human brain microvessel endothelial cells. J Neurochem 110:1049–1057
43. Morgan K, Obici S, Rossetti L (2004) Hypothalamic responses to long-chain fatty acids are nutritionally regulated. J Biol Chem 279:31139–31148
44. Moritz W, Leech CA, Ferrer J, Habener JF (2001) Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells. Endocrinology 142:129–138
45. Morton GJ, Schwartz MW (2011) Leptin and the central nervous system control of glucose metabolism. Physiol Rev 91:389–411
46. Morton GJ, Gelling RW, Niswender KD, Morrison CD, Rhodes CJ, Schwartz MW (2005) Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab 2:411–420
47. Müller WA, Faloona GR, Aguilar-Parada E, Unger RH (1970) Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N Engl J Med 283:109–115
48. Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L (2002a) Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51:271–275
49. Obici S, Zhang BB, Karkanias G, Rossetti L (2002b) Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8:1376–1382
50. Obici S, Feng Z, Arduini A, Conti R, Rossetti L (2003) Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med 9:756–761
51. Pocai A, Lam TK, Gutierrez-Juarez R, Obici S, Schwartz GJ, Bryan J, Aguilar-Bryan L, Rossetti L (2005) Hypothalamic K(ATP) channels control hepatic glucose production. Nature 434:1026–1031
52. Pocai A, Lam TK, Obici S, Gutierrez-Juarez R, Muse ED, Arduini A, Rossetti L (2006) Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J Clin Invest 116:1081–1091
53. Posey KA, Clegg DJ, Printz RL, Byun J, Morton GJ, Vivekanandan-Giri A, Pennathur S, Baskin DG, Heinecke JW, Woods SC, Schwartz MW, Niswender KD (2009) Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab 296:E1003–E1012
54. Rapoport SI (1996) In vivo labeling of brain phospholipids by long-chain fatty acids: relation to turnover and function. Lipids 31(Suppl):S97–S101
55. Rapoport SI, Chang MC, Spector AA (2001) Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. J Lipid Res 42:678–685
56. Reaven GM, Chen YD, Golay A, Swislocki AL, Jaspan JB (1987) Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 64:106–110
57. Ross R, Wang PY, Chari M, Lam CK, Caspi L, Ono H, Muse ED, Li X, Gutierrez-Juarez R, Light PE, Schwartz GJ, Rossetti L, Lam TK (2008) Hypothalamic protein kinase C regulates glucose production. Diabetes 57:2061–2065
58. Sandoval DA, Bagnol D, Woods SC, D’Alessio DA, Seeley RJ (2008) Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes 57:2046–2054
59. Schwartz MW, Seeley RJ, Tschöp MH, Woods SC, Morton GJ, Myers MG, D’Alessio D (2013) Cooperation between brain and islet in glucose homeostasis and diabetes. Nature 503:59–66
60. Su Y, Lam TK, He W, Pocai A, Bryan J, Aguilar-Bryan L, Gutierrez-Juarez R (2012) Hypothalamic leucine metabolism regulates liver glucose production. Diabetes 61:85–93
61. Taylor SI (1999) Deconstructing type 2 diabetes. Cell 97:9–12
62. Unson CG, Gurzenda EM, Merrifield RB (1989) Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides 10:1171–1177
63. Vranic M, Kawamori R, Wrenshall GA (1975) The role of insulin and glucagon in regulating glucose turnover in dogs during exercise. Med Sci Sports 7:27–33
64. Wang R, Cruciani-Guglielmacci C, Migrenne S, Magnan C, Cotero VE, Routh VH (2006) Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels. J Neurophysiol 95:1491–1498
65. Wetsel WC, Eraly SA, Whyte DB, Mellon PL (1993) Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons. Endocrinology 132:2360–2370
66. Yang CS, Lam CK, Chari M, Cheung GWC, Kokorovic A, Gao S, Leclerc I, Rutter GA, Lam TK (2010) Hypothalamic AMP-activated protein kinase regulates glucose production. Diabetes 59:2435–2443
67. Yue JT, Lam TK (2012) Lipid Sensing and insulin resistance in the brain. Cell Metab 15:646–655