FAT/CD36: A major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice

Diabetes

Volumn 62, Issue 8, 2013, Pages 2709-2716

  Foll, Christelle Le ^a   Dunn Meynell, Ambrose ^b   Musatov, Serguei ^c   Magnan, Christophe ^d   Levin, Barry E ^a,b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CARNITINE PALMITOYLTRANSFERASE; CD36 ANTIGEN; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LEPTIN; PARVOVIRUS VECTOR; PROOPIOMELANOCORTIN; SHORT HAIRPIN RNA; GLUCOSE BLOOD LEVEL; OLEIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCASS; CELL ENERGY; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; COMPARATIVE STUDY; CONTROLLED STUDY; FATTY ACID SENSING; FOOD INTAKE; GENE EXPRESSION; GENOTYPE; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HOMEOSTASIS; INSULIN BLOOD LEVEL; LIPID DIET; MALE; MEMBRANE POTENTIAL; MOUSE; NERVE CELL; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RAT; SUBCUTANEOUS FAT; WEIGHT GAIN; ZONA INCERTA; ANIMAL; BLOOD; BODY WEIGHT; C57BL MOUSE; DRUG EFFECTS; EATING; ENERGY METABOLISM; GENETICS; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; DRUG EFFECT;

ANIMALS; ANTIGENS, CD36; BLOOD GLUCOSE; BODY WEIGHT; EATING; ENERGY METABOLISM; FATTY ACIDS; HOMEOSTASIS; INSULIN; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; OLEIC ACID; RATS; RATS, SPRAGUE-DAWLEY; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 84891710015     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1689     Document Type: Article

References (34)

1. Kang L, Dunn-Meynell AA, Routh VH, et al. Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing. Diabetes 2006;55:412-420
2. Lam TK, Pocai A, Gutierrez-Juarez R, et al. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 2005;11: 320-327
3. Levin BE, Becker TC, Eiki J, Zhang BB, Dunn-Meynell AA. Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. Diabetes 2008;57: 1371-1379
4. Pocai A, Lam TK, Obici S, et al. Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J Clin Invest 2006;116:1081-1091
5. Le Foll C, Irani BG, Magnan C, Dunn-Meynell AA, Levin BE. Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing. Am J Physiol Regul Integr Comp Physiol 2009;297:R655-R664
6. Clément L, Cruciani-Guglielmacci C, Magnan C, et al. Intracerebroventricular infusion of a triglyceride emulsion leads to both altered insulin secretion and hepatic glucose production in rats. Pflugers Arch 2002;445:375-380
7. Migrenne S, Cruciani-Guglielmacci C, Kang L, et al. Fatty acid signaling in the hypothalamus and the neural control of insulin secretion. Diabetes 2006;55(Suppl. 2):S139-S144
8. Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 2002;51:271-275
9. Sokoloff L, Reivich M, Kennedy C, et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 1977;28:897-916
10. Escartin C, Pierre K, Colin A, et al. Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults. J Neurosci 2007;27:7094-7104
11. Edmond J, Robbins RA, Bergstrom JD, Cole RA, de Vellis J. Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture. J Neurosci Res 1987;18:551-561
12. Levin BE. Metabolic sensors: viewing glucosensing neurons from a broader perspective. Physiol Behav 2002;76:397-401
13. Oomura Y, Nakamura T, Sugimori M, Yamada Y. Effect of free fatty acid on the rat lateral hypothalamic neurons. Physiol Behav 1975;14:483-486
14. Wang R, Liu X, Hentges ST, et al. The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes 2004;53:1959-1965
15. Le Foll C, Irani BG, Magnan C, Dunn-Meynell AA, Levin BE. Effects of maternal genotype and diet on offspring glucose and fatty acid-sensing ventromedial hypothalamic nucleus neurons. Am J Physiol Regul Integr Comp Physiol 2009;297:R1351-R1357
16. Laugerette F, Passilly-Degrace P, Patris B, et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest 2005;115:3177-3184
17. Kang L, Routh VH, Kuzhikandathil EV, Gaspers LD, Levin BE. Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons. Diabetes 2004;53:549-559
18. Levin BE, Magnan C, Migrenne S, Chua SC Jr, Dunn-Meynell AA. The F-DIO obesity-prone rat is insulin resistant prior to obesity onset. Am J Physiol Regul Integr Comp Physiol 2005;289:R704-R711
19. Dunn-Meynell AA, Routh VH, Kang L, Gaspers L, Levin BE. Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucoseinhibited central neurons. Diabetes 2002;51:2056-2065
20. Kang L, Dunn-Meynell AA, Routh VH, Liu X, Levin BE. Knockdown of GK mRNA with GK RNA interference (RNAi) blocks ventromedial hypothalamic (VMH) neuronal glucosensing (Abstract). Diabetes 2004;53:A43
21. Koonen DP, Sung MM, Kao CK, et al. Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance. Diabetes 2010;59:1366-1375
22. Bonen A, Han XX, Habets DD, Febbraio M, Glatz JF, Luiken JJ. A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulinand AICAR-stimulated fatty acid metabolism. Am J Physiol Endocrinol Metab 2007;292:E1740-E1749
23. Jo YH, Su Y, Gutierrez-Juarez R, Chua S Jr. Oleic acid directly regulates POMC neuron excitability in the hypothalamus. J Neurophysiol 2009;101:2305-2316
24. Silver IA, Erecinska M. Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. J Neurosci 1994;14:5068-5076
25. Dunn-Meynell AA, Sanders NM, Compton D, et al. Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding. J Neurosci 2009;29:7015-7022
26. El-Yassimi A, Hichami A, Besnard P, Khan NA. Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. J Biol Chem 2008;283:12949-12959
27. Edmond J. Energy metabolism in developing brain cells. Can J Physiol Pharmacol 1992;70(Suppl.):S118-S129
28. Levin BE, Routh VH, Kang L, Sanders NM, Dunn-Meynell AA. Neuronal glucosensing: what do we know after 50 years? Diabetes 2004;53:2521- 2528
29. Pellerin L, Pellegri G, Martin JL, Magistretti PJ. Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc Natl Acad Sci USA 1998;95:3990-3995
30. Murphy BA, Fakira KA, Song Z, Beuve A, Routh VH. AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons. Am J Physiol Cell Physiol 2009; 297:C750-C758
31. Fioramonti X, Marsollier N, Song Z, et al. Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation. Diabetes 2010;59:519-528
32. Barichello T, Milioli G, Generoso JS, et al. Imipramine reverses depressivelike parameters in pneumococcal meningitis survivor rats. J Neural Transm 2012;119:653-660
33. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387: 903-908
34. Gastaldelli A, Cusi K, Pettiti M, et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology 2007;133:496-506