Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Yu, Qing ^a   Lou, Xiang Ming ^a   He, Yan ^b  

^a HANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^b Yiwu Maternity and Child Care Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; CCL20 PROTEIN, HUMAN;

ARTICLE; CELL MIGRATION; CHEMOTAXIS; CIRCULATING TUMOR CELL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PHENOTYPE; PREVALENCE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TH17 CELL; UTERINE CERVIX CANCER; CYTOLOGY; IMMUNOLOGY; METABOLISM; UTERINE CERVIX TUMOR;

CHEMOKINE CCL20; CHEMOTAXIS; FEMALE; HUMANS; PHENOTYPE; RECEPTORS, CCR6; TH17 CELLS; UTERINE CERVICAL NEOPLASMS;

EID: 84929500748     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120855     Document Type: Article

References (33)

1. Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer. 2002;2:342-350. PMID: 12044010
2. Kennedy R, Celis E. Multiple roles for CD4+ T cells in anti-tumor immune responses. Immunol Rev. 2008;222:129-144. doi: 10.1111/j.1600-065X.2008.00616.x PMID: 18363998
3. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441:235-238. PMID: 16648838
4. Leipe J, Grunke M, Dechant C, Reindl C, Kerzendorf U, Schulze-Koops H, et al. Role of Th17 cells in human autoimmune arthritis. Arthritis Rheum. 2010;62:2876-2885. doi: 10.1002/art.27622 PMID: 20583102
5. Strober W, Zhang F, Kitani A, Fuss I, Fichtner-Feigl S. Proinflammatory cytokines underlying the inflammation of Crohn's disease. Curr Opin Gastroenterol. 2010;26:310-317. doi: 10.1097/MOG. 0b013e328339d099 PMID: 20473158
6. Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, et al. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med. 2010;16:191-197. doi: 10.1038/nm.2077 PMID: 20062065
7. Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol. 2009;10:514-523. doi: 10.1038/ni.1716 PMID: 19305396
8. Zhang JP, Yan J, Xu J, Pang XH, Chen MS, Li L, et al. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol. 2009;50:980-989. doi: 10. 1016/j.jhep. 2008.12.033 PMID: 19329213
9. Maruyama T, Kono K, Mizukami Y, Kawaguchi Y, Mimura K, Watanabe M, et al. Distribution of Th17 cells and FoxP3 (+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer. Cancer Sci. 2010;101:1947-1954. doi: 10.1111/j.1349-7006.2010.01624.x PMID: 20550524
10. Chen X, Wan J, Liu J, Xie W, Diao X, Xu J, et al. Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patients. Lung Cancer. 2010;69:348-354. doi: 10.1016/j. lungcan. 2009.11.013 PMID: 20022135
11. Chen D, Hu Q, Mao C, Jiao Z, Wang S, Yu L, et al. Increased IL-17-producing CD4 (+) T cells in patients with esophageal cancer. Cell Immunol. 2012;272:166-174. doi: 10.1016/j.cellimm.2011.10.015 PMID: 22082565
12. Yu Q, Lou XM, He Y. Prediction of local recurrence in cervical cancer by a Cox model comprised of lymph node status, lymph-vascular space invasion, and intratumoral Th17 cell-infiltration. Med Oncol. 2014;31:795. doi: 10.1007/s12032-013-0795-1 PMID: 24310812
13. Mackay CR. Moving targets: cell migration inhibitors as new anti-inflammatory therapies. Nat Immunol. 2008;9:988-998. doi: 10.1038/ni.f.210 PMID: 18711436
14. Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer. 2012;12:298-306. doi: 10.1038/nrc3245 PMID: 22419253
15. Sato W, Aranami T, Yamamura T. Cutting edge: Human Th17 cells are identified as bearing CCR2 +CCR5-phenotype. J Immunol. 2007;178:7525-7529. PMID: 17548586
16. Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol. 2007;8:639-646. PMID: 17486092
17. Pang YL, Zhang HG, Peng JR, Pang XW, Yu S, Xing Q, et al. The immunosuppressive tumor microenvironment in hepatocellular carcinoma. Cancer Immunol Immunother. 2009;58:877-886. doi: 10. 1007/s00262-008-0603-5 PMID: 18941744
18. Chen KJ, Lin SZ, Zhou L, Xie HY, Zhou WH, Taki-Eldin A, et al. Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis. PLoS One. 2011;6:e24671. doi: 10.1371/journal.pone.0024671 PMID: 21935436
19. Hirata T, Osuga Y, Takamura M, Kodama A, Hirota Y, Koga K, et al. Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells. Endocrinology. 2010;151:5468-5476. doi: 10.1210/en. 2010-0398 PMID: 20881253
20. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol. 2008;8:523-532. doi: 10.1038/nri2343 PMID: 18566595
21. Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med. 2003;9:562-567. PMID: 12704383
22. Kryczek I, Bruce AT, Gudjonsson JE, Johnston A, Aphale A, Vatan L, et al. Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol. 2008;181:4733-4741. PMID: 18802076
23. Lee JJ, Chang YL, Lai WL, Ko JY, Kuo MY, Chiang CP, et al. Increased prevalence of interleukin-17-producing CD4 (+) tumor infiltrating lymphocytes in human oral squamous cell carcinoma. Head Neck. 2011;33:1301-1308. doi: 10.1002/hed.21607 PMID: 21837700
24. Chen D, Jiang R, Mao C, Shi L, Wang S, Yu L, et al. Chemokine/chemokine receptor interactions contribute to the accumulation of Th17 cells in patients with esophageal squamous cell carcinoma. Hum Immunol. 2012;73:1068-1072. doi: 10.1016/j.humimm.2012.07.333 PMID: 22863447
25. Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, et al. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood. 2009;114:1141-1149. doi: 10.1182/blood-2009-03-208249 PMID: 19470694
26. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140:883-899. doi: 10.1016/j.cell.2010.01.025 PMID: 20303878
27. Liu J, Duan Y, Cheng X, Chen X, Xie W, Long H, et al. IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma. Biochem Biophys Res Commun. 2011;407:348-354. doi: 10.1016/j.bbrc.2011.03.021 PMID: 21396350
28. Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 2004;21:137-148. PMID: 15308095
29. Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, et al. T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity. 2009;31:787-798. doi: 10.1016/j.immuni.2009. 09.014 PMID: 19879162
30. Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008;112:362-373. doi: 10.1182/blood-2007-11-120998 PMID: 18354038
31. Moser B, Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol. 2001;2:123-128. PMID: 11175804
32. Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med. 2007;204:2803-2812. PMID: 18025126
33. Siegmund K, Feuerer M, Siewert C, Ghani S, Haubold U, Dankof A, et al. Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood. 2005;106:3097-3104. PMID: 16014565