Increased IL-17-producing CD4 + T cells in patients with esophageal cancer

Cellular Immunology

Volumn 272, Issue 2, 2012, Pages 166-174

  Chen, Deyu ^a   Hu, Qin ^a   Mao, Chaoming ^a   Jiao, Zhijun ^a   Wang, Shengjun ^b   Yu, Lichao ^a   Xu, Ying ^a   Dai, Dongfang ^a   Yin, Lijia ^a   Xu, Huaxi ^b  

^a AFFILIATED HOSPITAL OF JIANGSU UNIVERSITY   (China)

^b JIANGSU UNIVERSITY   (China)

Author keywords

Chemokine; Cytokine; Esophageal cancer; Th17 cell

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER PATIENT; CD4 LYMPHOCYTE PERCENTAGE; CONTROLLED STUDY; DISEASE MARKER; ESOPHAGUS CANCER; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE DIFFERENTIATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; TH17 CELL; TUMOR MICROENVIRONMENT;

ADULT; AGED; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; CHEMOKINE CCL20; CHEMOKINE CCL22; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; INTERLEUKIN-17; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; MALE; MIDDLE AGED; NEOPLASM STAGING; RECEPTORS, CCR4; RECEPTORS, CCR6; TH17 CELLS; TUMOR MICROENVIRONMENT;

EID: 83955162317     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2011.10.015     Document Type: Article

References (49)

1. Enzinger P.C., Mayer R.J. Esophageal cancer. N. Engl. J. Med. 2003, 349:2241-2252.
2. Parkin D.M., Bray F.I., Devesa S.S. Cancer burden in the year 2000. The global picture. Eur. J. Cancer 2001, 37(Suppl. 8):S4-66.
3. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics, 2002. CA Cancer J. Clin. 2005, 55:74-108.
4. Guo Y., Su M., Liu Z., Lian S., Hu B., Tian D. The preliminary pathologic study of epithelial proliferation and intraepithelial infiltrating inflammatory cells in esophageal carcinoma high-risk population. J. Shantou Univ. Med. Coll. 2007, 1:30-35.
5. Kolls J.K., Linden A. Interleukin-17 family members and inflammation. Immunity 2004, 21:467-476.
6. Bettelli E., Oukka M., Kuchroo V.K. T(H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 2007, 8:345-350.
7. Chen X., Vodanovic-Jankovic S., Johnson B., Keller M., Komorowski R., Drobyski W.R. Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. Blood 2007, 110:3804-3813.
8. Yang L., Anderson D.E., Baecher-Allan C., Hastings W.D., Bettelli E., Oukka M., Kuchroo V.K., Hafler D.A. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 2008, 454:350-352.
9. Volpe E., Servant N., Zollinger R., Bogiatzi S.I., Hupe P., Barillot E., Soumelis V. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat. Immunol. 2008, 9:650-657.
10. Manel N., Unutmaz D., Littman D.R. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 2008, 9:641-649.
11. Moser B., Loetscher P. Lymphocyte traffic control by chemokines. Nat. Immunol. 2001, 2:123-128.
12. Steiner G.E., Newman M.E., Paikl D., Stix U., Memaran-Dagda N., Lee C., Marberger M.J. Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. Prostate 2003, 56:171-182.
13. Sfanos K.S., Bruno T.C., Maris C.H., Xu L., Thoburn C.J., DeMarzo A.M., Meeker A.K., Isaacs W.B., Drake C.G. Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin. Cancer Res. 2008, 14:3254-3261.
14. Numasaki M., Watanabe M., Suzuki T., Takahashi H., Nakamura A., McAllister F., Hishinuma T., Goto J., Lotze M.T., Kolls J.K., Sasaki H. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J. Immunol. 2005, 175:6177-6189.
15. Chen X., Wan J., Liu J., Xie W., Diao X., Xu J., Zhu B., Chen Z. Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patients. Lung Cancer 2010, 69:348-354.
16. Zhu X., Mulcahy L.A., Mohammed R.A., Lee A.H., Franks H.A., Kilpatrick L., Yilmazer A., Paish E.C., Ellis I.O., Patel P.M., Jackson A.M. IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines. Breast Cancer Res. 2008, 10:R95.
17. Le Gouvello S., Bastuji-Garin S., Aloulou N., Mansour H., Chaumette M.T., Berrehar F., Seikour A., Charachon A., Karoui M., Leroy K., Farcet J.P., Sobhani I. High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas. Gut 2008, 57:772-779.
18. Miyahara Y., Odunsi K., Chen W., Peng G., Matsuzaki J., Wang R.F. Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proc. Natl. Acad. Sci. USA 2008, 105:15505-15510.
19. Zhang J.P., Yan J., Xu J., Pang X.H., Chen M.S., Li L., Wu C., Li S.P., Zheng L. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J. Hepatol. 2009, 50:980-989.
20. Hirahara N., Nio Y., Sasaki S., Minari Y., Takamura M., Iguchi C., Dong M., Yamasawa K., Tamura K. Inoculation of human interleukin-17 gene-transfected Meth-A fibrosarcoma cells induces T cell-dependent tumor-specific immunity in mice. Oncology 2001, 61:79-89.
21. Hirahara N., Nio Y., Sasaki S., Takamura M., Iguchi C., Dong M., Yamasawa K., Itakura M., Tamura K. Reduced invasiveness and metastasis of Chinese hamster ovary cells transfected with human interleukin-17 gene. Anticancer Res. 2000, 20:3137-3142.
22. Benchetrit F., Ciree A., Vives V., Warnier G., Gey A., Sautes-Fridman C., Fossiez F., Haicheur N., Fridman W.H., Tartour E. Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism. Blood 2002, 99:2114-2121.
23. Kato T., Furumoto H., Ogura T., Onishi Y., Irahara M., Yamano S., Kamada M., Aono T. Expression of IL-17 mRNA in ovarian cancer. Biochem. Biophys. Res. Commun. 2001, 282:735-738.
24. Hao L., Zhang C., Qiu Y., Wang L., Luo Y., Jin M., Zhang Y., Guo T.B., Matsushima K. Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer. Cancer Lett. 2007, 253:34-42.
25. de Visser K.E., Eichten A., Coussens L.M. Paradoxical roles of the immune system during cancer development. Nat. Rev. Cancer 2006, 6:24-37.
26. Condeelis J., Pollard J.W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006, 124:263-266.
27. Wu C., Wang S., Wang F., Chen Q., Peng S., Zhang Y., Qian J., Jin J., Xu H. Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia. Clin. Exp. Immunol. 2009, 158:199-204.
28. Zhang B., Rong G., Wei H., Zhang M., Bi J., Ma L., Xue X., Wei G., Liu X., Fang G. The prevalence of Th17 cells in patients with gastric cancer. Biochem. Biophys. Res. Commun. 2008, 374:533-537.
29. Gutcher I., Donkor M.K., Ma Q., Rudensky A.Y., Flavell R.A., Li M.O. Autocrine transforming growth factor-beta1 promotes in vivo Th17 cell differentiation. Immunity 2011, 34:396-408.
30. Acosta-Rodriguez E.V., Napolitani G., Lanzavecchia A., Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 2007, 8:942-949.
31. Zhou L., Ivanov, Spolski R., Min R., Shenderov K., Egawa T., Levy D.E., Leonard W.J., Littman D.R. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 2007, 8:967-974.
32. Mao C., Wang S., Jiang Q., Tong J., Ma J., Yang M., Xu X., Qiu G., Shao Q., Li L., Xu H. Increased CD4CD25+FOXP3+ regulatory T Cells in cancer patients from conversion of CD4+CD25-T cells through tumor-derived factors. Onkologie 2008, 31:243-248.
33. Ye Z.J., Zhou Q., Gu Y.Y., Qin S.M., Ma W.L., Xin J.B., Tao X.N., Shi H.Z. Generation and differentiation of IL-17-producing CD4+ T cells in malignant pleural effusion. J. Immunol. 2010, 185:6348-6354.
34. Das J., Ren G., Zhang L., Roberts A.I., Zhao X., Bothwell A.L., Van Kaer L., Shi Y., Das G. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J. Exp. Med. 2009, 206:2407-2416.
35. Ghoreschi K., Laurence A., Yang X.P., Tato C.M., McGeachy M.J., Konkel J.E., Ramos H.L., Wei L., Davidson T.S., Bouladoux N., Grainger J.R., Chen Q., Kanno Y., Watford W.T., Sun H.W., Eberl G., Shevach E.M., Belkaid Y., Cua D.J., Chen W., O'Shea J.J. Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling. Nature 2010, 467:967-971.
36. Axtell R.C., Raman C., Steinman L. Interferon-beta exacerbates Th17-mediated inflammatory disease. Trends Immunol. 2011, 32:272-277.
37. Ciree A., Michel L., Camilleri-Broet S., Jean Louis F., Oster M., Flageul B., Senet P., Fossiez F., Fridman W.H., Bachelez H., Tartour E. Expression and activity of IL-17 in cutaneous T-cell lymphomas (mycosis fungoides and Sezary syndrome). Int. J. Cancer 2004, 112:113-120.
38. Feng T., Qin H., Wang L., Benveniste E.N., Elson C.O., Cong Y. Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production. J. Immunol. 2011, 186:6313-6318.
39. Zhang J.Y., Zhang Z., Lin F., Zou Z.S., Xu R.N., Jin L., Fu J.L., Shi F., Shi M., Wang H.F., Wang F.S. Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology 2010, 51:81-91.
40. Lo Re S., Dumoutier L., Couillin I., Van Vyve C., Yakoub Y., Uwambayinema F., Marien B., van den Brule S., Van Snick J., Uyttenhove C., Ryffel B., Renauld J.C., Lison D., Huaux F. IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. J. Immunol. 2010, 184:6367-6377.
41. Murugaiyan G., Saha B. Protumor vs antitumor functions of IL-17. J. Immunol. 2009, 183:4169-4175.
42. Martin-Orozco N., Dong C. The IL-17/IL-23 axis of inflammation in cancer: friend or foe?. Curr. Opin. Investig. Drugs 2009, 10:543-549.
43. Kesselring R., Thiel A., Pries R., Trenkle T., Wollenberg B. Human Th17 cells can be induced through head and neck cancer and have a functional impact on HNSCC development. Br. J. Cancer 2010, 103:1245-1254.
44. Gnerlich J.L., Mitchem J.B., Weir J.S., Sankpal N.V., Kashiwagi H., Belt B.A., Porembka M.R., Herndon J.M., Eberlein T.J., Goedegebuure P., Linehan D.C. Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer. J. Immunol. 2010, 185:4063-4071.
45. Numasaki M., Fukushi J., Ono M., Narula S.K., Zavodny P.J., Kudo T., Robbins P.D., Tahara H., Lotze M.T. Interleukin-17 promotes angiogenesis and tumor growth. Blood 2003, 101:2620-2627.
46. Oo Y.H., Adams D.H. The role of chemokines in the recruitment of lymphocytes to the liver. J. Autoimmun. 2010, 34:45-54.
47. Singh S.P., Zhang H.H., Foley J.F., Hedrick M.N., Farber J.M. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J. Immunol. 2008, 180:214-221.
48. Hirota K., Yoshitomi H., Hashimoto M., Maeda S., Teradaira S., Sugimoto N., Yamaguchi T., Nomura T., Ito H., Nakamura T., Sakaguchi N., Sakaguchi S. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J. Exp. Med. 2007, 204:2803-2812.
49. Annunziato F., Cosmi L., Santarlasci V., Maggi L., Liotta F., Mazzinghi B., Parente E., Fili L., Ferri S., Frosali F., Giudici F., Romagnani P., Parronchi P., Tonelli F., Maggi E., Romagnani S. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 2007, 204:1849-1861.