Mismatch repair-deficient crypt foci in lynch syndrome-molecular alterations and association with clinical parameters

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Staffa, Laura ^a,b   Echterdiek, Fabian ^a,b   Nelius, Nina ^a,b   Benner, Axel ^b   Werft, Wiebke ^b   Lahrmann, Bernd ^c   Grabe, Niels ^c   Schneider, Martin ^a   Tariverdian, Mirjam ^a   Von Knebel Doeberitz, Magnus ^a,b   Bläker, Hendrik ^d   Kloor, Matthias ^a,b  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; AIM2 PROTEIN, HUMAN; ASTE1 PROTEIN, HUMAN; BAX PROTEIN, HUMAN; DNA BINDING PROTEIN; MLH1 PROTEIN, HUMAN; MSH2 PROTEIN, HUMAN; MUTL PROTEIN HOMOLOG 1; NUCLEAR PROTEIN; PROTEIN; PROTEIN BAX; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ABERRANT CRYPT FOCUS; ADULT; AIM2 GENE; ARTICLE; ASTE1 GENE; BAX GENE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENE INACTIVATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MALIGNANT TRANSFORMATION; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MUTATIONAL ANALYSIS; PREVALENCE; PROTEIN EXPRESSION; SMALL INTESTINE MUCOSA; TUMOR GENE; TUMOR LOCALIZATION; AGE; AGED; GENETICS; INTESTINE MUCOSA; MIDDLE AGED; PATHOLOGY; YOUNG ADULT;

ABERRANT CRYPT FOCI; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGE FACTORS; AGED; BCL-2-ASSOCIATED X PROTEIN; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA-BINDING PROTEINS; HUMANS; INTESTINAL MUCOSA; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTL PROTEIN HOMOLOG 1; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; PROTEINS; YOUNG ADULT;

EID: 84929492513     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0121980     Document Type: Article

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