Somatic mutations in MLH1 and MSH2 are a frequent cause of mismatch-repair deficiency in lynch syndrome-like tumors

Gastroenterology

Volumn 146, Issue 3, 2014, Pages

  Mensenkamp, Arjen R ^a   Vogelaar, Ingrid P ^a   Van Zelst Stams, Wendy A G ^a   Goossens, Monique ^a   Ouchene, Hicham ^a   Hendriks Cornelissen, Sandra J B ^a   Kwint, Michael P ^a   Hoogerbrugge, Nicoline ^a   Nagtegaal, Iris D ^a   Ligtenberg, Marjolijn J L ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Colorectal Cancer; Genetic; Lynch Like Syndrome; Mismatch Repair Deficiency

Indexed keywords

ARTICLE; CLINICAL ARTICLE; GENE; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HETEROZYGOSITY LOSS; HUMAN; METHYLATION; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MLH1 GENE; MSH2 GENE; PRIORITY JOURNAL; PROMOTER REGION; SOMATIC MUTATION;

COLORECTAL CANCER; GENETIC; LYNCH-LIKE SYNDROME; MISMATCH REPAIR DEFICIENCY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADOLESCENT; ADULT; AGED; BRAIN NEOPLASMS; COHORT STUDIES; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; COMORBIDITY; DNA METHYLATION; DNA MISMATCH REPAIR; GERM-LINE MUTATION; HUMANS; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASTIC SYNDROMES, HEREDITARY; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84894353372     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.12.002     Document Type: Article

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