Temozolomide increases the number of mismatch repair-deficient intestinal crypts and accelerates tumorigenesis in a mouse model of lynch syndrome

Gastroenterology

Volumn 147, Issue 5, 2014, Pages 1064-1072.e5

  Wojciechowicz, Kamila ^a   Cantelli, Erika ^a   Van Gerwen, Bastiaan ^a   Plug, Mirjam ^a   Van Der Wal, Anja ^a   Delzenne Goette, Elly ^a   Song, Ji Ying ^b   De Vries, Sandra ^a   Dekker, Marleen ^a   Riele, Hein Te ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b Department of Animal Pathology ^*  (Netherlands)

Author keywords

Cancer Risk; Carcinogen; Defective Mismatch Repair; Dietary Factors

Indexed keywords

DNA; PROTEIN MSH2; TAMOXIFEN; TEMOZOLOMIDE; DACARBAZINE; MSH2 PROTEIN, MOUSE;

ADENOCARCINOMA; ADENOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CARCINOGENESIS; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINAL STEM CELL; INTESTINE CRYPT; INTESTINE EPITHELIUM CELL; LOXP SITE; MALE; MISMATCH REPAIR; MOUSE; MUTAGENESIS; NONHUMAN; ANALOGS AND DERIVATIVES; ANIMAL; CANCER STEM CELL; CELL TRANSFORMATION; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENETICS; INTESTINE; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; RISK FACTOR; TIME; TOXICITY;

ADENOCARCINOMA; ADENOMA; ANIMALS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DACARBAZINE; DISEASE MODELS, ANIMAL; DNA MISMATCH REPAIR; FEMALE; INTESTINES; MALE; MICE, KNOCKOUT; MUTS HOMOLOG 2 PROTEIN; NEOPLASTIC STEM CELLS; RISK FACTORS; TIME FACTORS;

EID: 84908268312     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.07.052     Document Type: Article

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