Effect of ascorbate on plasminogen activator inhibitor-1 expression and release from platelets and endothelial cells in an in-vitro model of sepsis

Blood Coagulation and Fibrinolysis

Volumn 26, Issue 4, 2015, Pages 436-442

  Swarbreck, Scott B ^a   Secor, Dan ^a   Ellis, Christopher G ^a   Sharpe, Michael D ^a   Wilson, John X ^b   Tyml, Karel ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

ascorbate; endothelial cell; plasminogen activator inhibitor 1; platelet; sepsis

Indexed keywords

ASCORBIC ACID; LIPOPOLYSACCHARIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBIN; TUMOR NECROSIS FACTOR ALPHA; ANTIOXIDANT; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CELL CULTURE; CELL ISOLATION; CELL PH; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; EXTRACELLULAR SPACE; FEMALE; FIBRINOLYSIS; IN VITRO STUDY; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; SEPSIS; THROMBOCYTE; ANIMAL; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BLOOD PLATELETS; CELLS, CULTURED; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; PLASMINOGEN ACTIVATOR INHIBITOR 1; RNA, MESSENGER; SEPSIS;

EID: 84929464101     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0000000000000273     Document Type: Article

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