Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets

Thrombosis and Haemostasis

Volumn 107, Issue 1, 2012, Pages 99-110

  Etulain, Julia ^a   Negrotto, Soledad ^a   Carestia, Agostina ^a   Pozner, Roberto Gabriel ^a   Romaniuk, María Albertina ^a   D'Atri, Lina Paola ^a   Klement, Giannoula Lakka ^b,c   Schattner, Mirta ^a  

^a Universidad Nacional de Río Cuarto Consejo Nacional de Investigaciones Científicas y Técnicas   (Argentina)

^b TUFTS MEDICAL CENTER   (United States)

^c ST ELIZABETH'S MEDICAL CENTER   (United States)

Author keywords

Acidosis; Inflammation; Neutrophils; P selectin; Platelets

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA2BBETA3 INTEGRIN; CD40 LIGAND; COLLAGEN; ENDOSTATIN; INTEGRIN; PADGEM PROTEIN; PHOSPHATIDYLSERINE; STROMAL CELL DERIVED FACTOR 1ALPHA; THROMBIN; THROMBOXANE B2; UNCLASSIFIED DRUG; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ACIDOSIS; ARTICLE; BLOOD CLOT RETRACTION; BLOOD CLOTTING; CELL GRANULE; CELL SPREADING; CELL SURVIVAL; CONTROLLED STUDY; HEMOSTASIS; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE AGGREGATION; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PH; PLATELET MICROPARTICLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION;

ACIDOSIS; ADENOSINE TRIPHOSPHATE; BLOOD COAGULATION; BLOOD PLATELETS; CHEMOKINE CXCL12; ENDOSTATINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEMOSTASIS; HUMANS; INFLAMMATION; MICROSCOPY, FLUORESCENCE; NEUTROPHILS; PHOSPHATIDYLSERINES; PHOSPHORYLATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET TRANSFUSION; THROMBOXANE B2; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VON WILLEBRAND FACTOR;

EID: 84855326138     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH11-06-0443     Document Type: Article

References (39)

1. Rosskopf D. Sodium-hydrogen exchange and platelet function. J Thromb Thrombolysis 1999; 8: 15-24.
2. DeClerck K, Elble RC. The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy. Front Biosci 2010; 15: 213-225.
3. Huang Y, McNamara JO. Ischemic stroke: "acidotoxicity"is a perpetrator. Cell 2004; 118: 665-666.
4. Lim S. Metabolic acidosis. Acta Med Indones 2007; 39: 145-150.
5. Ricciardolo FL, Gaston B, Hunt J. Acid stress in the pathology of asthma. J Allergy Clin Immunol 2004; 113: 610-619.
6. Marumo M, Suehiro A, Kakishita E, et al. Extracellular pH affects platelet aggregation associated with modulation of store-operated Ca(2+) entry. Thromb Res 2001; 104: 353-360.
7. Patscheke H. Shape and functional properties of human platelets washed with acid citrate. Haemostasis 1981; 10: 14-27.
8. Rogers AB, Des Prez RM. The effect of pH on human platelet aggregation induced by epinephrine and ADP. Proc Soc Exp Biol Med 1972; 139: 1100-1103.
9. Watts SE, Tunbridge LJ, Lloyd JV. Storage of platelets for tests of platelet function: effects of pH on platelet aggregation and liberation of beta-thromboglobulin. Thromb Res 1983; 29: 343-353.
10. Romaniuk MA, Tribulatti MV, Cattaneo V, et al. Human platelets express and are activated by Galectin-8. Biochem J 2010; 432: 535-547.
11. Etulain J, Lapponi MJ, Patrucchi SJ, et al. Hyperthermia inhibits platelet haemostatic functions and selectively regulates the release of alpha-granule proteins. J Thromb Haemost 2011; 9: 1562-1571.
12. Obergfell A, Eto K, Mocsai A, et al. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol 2002; 157: 265-275.
13. Pacienza N, Pozner RG, Bianco GA, et al. The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation. Faseb J 2008; 22: 1113-1123.
14. Negrotto S, Malaver E, Alvarez ME, et al. Aspirin and salicylate suppress polymorphonuclear apoptosis delay mediated by proinflammatory stimuli. J Pharmacol Exp Ther 2006; 319: 972-979.
15. Betsuyaku T, Liu F, Senior RM, et al. A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation. J Clin Invest 1999; 103: 825-832.
16. Nilsson C, Kagedal K, Johansson U, et al. Analysis of cytosolic and lysosomal pH in apoptotic cells by flow cytometry. Methods Cell Sci 2003; 25: 185-194.
17. Shattil SJ, Newman PJ. Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood 2004; 104: 1606-1615.
18. Woodside DG, Obergfell A, Leng L, et al. Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains. Curr Biol 2001; 11: 1799-1804.
19. Flevaris P, Stojanovic A, Gong H, et al. A molecular switch that controls cell spreading and retraction. J Cell Biol 2007; 179: 553-565.
20. Munnix IC, Cosemans JM, Auger JM, et al. Platelet response heterogeneity in thrombus formation. Thromb Haemost 2009; 102: 1149-1156.
21. Sinauridze EI, Kireev DA, Popenko NY, et al. Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost 2007; 97: 425-434.
22. Nurden AT, Nurden P, Sanchez M, et al. Platelets and wound healing. Front Biosci 2008; 13: 3532-3548.
23. Wagner DD. New links between inflammation and thrombosis. Arterioscler Thromb Vasc Biol 2005; 25: 1321-1324.
24. Italiano JE, Jr., Richardson JL, Patel-Hett S, et al. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008; 111: 1227-1233.
25. Kamykowski J, Carlton P, Sehgal S, et al. Quantitative immunofluorescence mapping reveals little functional co-clustering of proteins within platelet {alpha}-granules. Blood 2011; 118: 1190-1191.
26. Ma L, Perini R, McKnight W, et al. Proteinase-activated receptors 1 and 4 counterregulate endostatin and VEGF release from human platelets. Proc Natl Acad Sci USA 2005; 102: 216-220.
27. Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood 2003; 102: 449-461.
28. Lam FW, Burns AR, Smith CW, et al. Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1. Am J Physiol Heart Circ Physiol 2010; 300: H468-475.
29. Trevani AS, Andonegui G, Giordano M, et al. Extracellular acidification induces human neutrophil activation. J Immunol 1999; 162: 4849-4857.
30. Brunetti M, Martelli N, Manarini S, et al. Polymorphonuclear leukocyte apoptosis is inhibited by platelet-released mediators, role of TGFbeta-1. Thromb Haemost 2000; 84: 478-483.
31. Andonegui G, Trevani AS, Lopez DH, et al. Inhibition of human neutrophil apoptosis by platelets. J Immunol 1997; 158: 3372-3377.
32. Maggini J, Raiden S, Salamone G, et al. Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors. Front Biosci 2009; 14: 2372-2385.
33. Nachmias VT, Yoshida K, Glennon MC. Lowering pH in blood platelets dissociates myosin phosphorylation from shape change and myosin association with the cytoskeleton. J Cell Biol 1987; 105: 1761-1769.
34. Herbaczynska-Cedro K, Truskolaski P, Huszczuk A, et al. Hypoventilation and elevation of end-expiratory pressure release a substance which relaxes isolated arteries and disaggregates platelets in the presence of cyclooxygenase inhibitors. Prostaglandins 1981; 21: 707-717.
35. van Nispen Tot Pannerden H, de Haas F, Geerts W, et al. The platelet interior revisited: electron tomography reveals tubular alpha granule subtypes. Blood 2010; 116: 1147-1156.
36. Sturm A, Hebestreit H, Koenig C, et al. Platelet proinflammatory activity in clinically stable patients with CF starts in early childhood. J Cyst Fibros 2010; 9: 179-186.
37. Yaguchi A, Lobo FL, Vincent JL, et al. Platelet function in sepsis. J Thromb Haemost 2004; 2: 2096-2102.
38. Babich V, Knipe L, Hewlett L, et al. Differential effect of extracellular acidosis on the release and dispersal of soluble and membrane proteins secreted from the Weibel-Palade body. J Biol Chem 2009; 284: 12459-12468.
39. Ho-Tin-Noe B, Goerge T, Wagner DD. Platelets: guardians of tumor vasculature. Cancer Res 2009; 69: 5623-5626.