Animal models of sepsis

Journal of Investigative Surgery

Volumn 14, Issue 4, 2001, Pages 195-212

  Freise, H ^a   Bruckner U B ^a   Spiegel, H U ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Animal models; Clinical relevance; Intercurrent diseases; Sepsis; Therapy

Indexed keywords

ANTIBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC THERAPY; BACTEREMIA; BACTERIUM; BACTERIUM CONTAMINATION; BOLUS INJECTION; CLASSIFICATION; CLINICAL FEATURE; COMORBIDITY; CONTROLLED STUDY; DEVELOPMENT; ENDOTOXEMIA; ENTEROBACTERIACEAE; FECES; HUMAN; IMMUNITY; IMMUNOLOGY; IMPLANTATION; INFECTION; INOCULATION; INTESTINE PERFORATION; NONHUMAN; PATHOGENICITY; PATHOPHYSIOLOGY; PERITONEAL CAVITY; PRIORITY JOURNAL; RAT; RESUSCITATION; REVIEW; SEPSIS; SIMULATION; STANDARDIZATION; SURGERY; THERAPY; VALIDATION PROCESS;

ANIMALS; DISEASE MODELS, ANIMAL; SEPSIS;

EID: 0034778208     PISSN: 08941939     EISSN: None     Source Type: Journal    
DOI: 10.1080/089419301750420232     Document Type: Review

References (140)

1. Increase in national hospital discharge survey rates for septicemia-United States, 1979-1987
2. Annual summary of births, marriages, divorces and deaths: United States 1988
3. Outcome of patients with sepsis and septic shock after ICU treatment
4. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
5. The pathogenesis of sepsis
6. Why sepsis trials fail
7. Immunologic dissonance: A continuing evolution in our understanding of the Systemic Inflammatory Response Syndrome (SIRS) and the Multiple Organ Dysfunction Syndrome (MODS)
8. Improvement of monocyte function-a new therapeutic approach?
9. Serum cytokine levels in human septic shock-relation to multiple-system organ failure and mortality
10. Thirty years of antimediator treatment in sepsis and septic shock-what have we learned?
11. Animal models of sepsis and shock: A review and lessons learned
12. Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis
13. What determines prognosis in sepsis? Evidence for a comprehensive individual patient risk assessment approach to the design and analysis of clinical trials
14. Comparison of two polymorphisms of the interleukin-1 gene family: Interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis
15. Association of TNF2, a TNF-α promoter polymorphism, with septic shock susceptibility and mortality: A multicenter study
16. Surgery and the release of a neutrophil Fcγ receptor
17. Rat intraperitoneal sepsis-a clinically relevant model
18. Anti-infective effect of poly-β1-6-glucotriosyl-β1-3-glycopyranose glucan in vivo
19. Treatment of experimental gram-negative and gram-positive bacterial sepsis with the hemoregulatory peptide SK&F 107647
20. Experimental infections with anaerobic bacteria in mice
21. The natural history of the systemic inflammatory response syndrome (SIRS): A prospective study
22. Endotoxaemia: An early predictor of septicaemia in febrile patients
23. Mediators of septic shock: New approaches for interrupting the endogenous inflammatory cascade
24. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome
25. Tissue tumor necrosis factor mRNA expression following cecal ligation and puncture or intraperitoneal injection of endotoxin
26. Laboratory models of sepsis and septic shock
27. Endotoxin (E) administration produces abnormal cardiovascular (CV) responses in normal humans
28. Inhibition of cyclo-oxygenase attenuates the metabolic response to endotoxin in humans
29. Continuous infusion of endotoxin from an osmotic pump in the conscious, unrestrained rat: A unique model of chronic endotoxemia
30. Systemic and regional hemodynamic effects of cyclo-oxygenase and thromboxane synthetase inhibition in normal and hyperdynamic endotoxemic rabbits
31. Comparison of the haemodynamic effects of nitric oxide synthase inhibition and nitric oxide scavenging in endotoxaemic sheep
32. Clinical detection of LPS and animal models of endotoxemia
33. Comparison of a recombinant endotoxin-neutralizing protein with a human monoclonal antibody to endotoxin for the treatment of Escherichia coli sepsis in rats
34. Galactosamine-induced sensitization to the lethal effects of endotoxin
35. A conscious septic dog model with hemodynamic and metabolic responses similar to responses of humans
36. Skeletal microcirculatory responses to hyperdynamic escherichia coli sepsis in unanesthetized rats
37. Role of nitric oxide in the hemodynamic changes of sepsis
38. Anit-tumor necrosis factor antibody treatment of recurrent bacteremia in a baboon model
39. Pulmonary artery endothelial cell function in swine pseudomonas sepsis
40. Effects of filter pore size on efficiacy of continous arteriovenous hemofiltration therapy for Staphyloccus aureus-induced septicemia in immature swine
41. Polymicrobial sepsis but not low dose endotoxin infusion causes decreased splenocyte IL-2/IFN-γ release while increasing IL-4/IL-10 production
42. Sepsis and endotoxemia stimulate intestinal interleukin-6 production
43. Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin
44. Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture
45. Calcium: A regulator of the inflammatory response in endotoxemia and sepsis
46. Choice of bacteria in animal models of sepsis
47. 2-exchange and energy metabolism during hyperdynamic porcine endotoxemia
48. Post-hoc analyses in sepsis trials: A formula for disappointment?
49. Steroid controversy in sepsis and septic shock: A meta-analysis
50. Meningococcal disease as a model to evaluate novel anti-sepsis strategies
51. Sepsis and septic shock-A review of laboratory models and a proposal
52. Early but not delayed continuous arteriovenous hemofiltration improves cardiovascular function in sepsis in dogs
53. Glucose tolerance and insulin secretion in experimental peritonitis in the rat
54. Distribution of free and liposome-encapsulated Cefoxitin in experimental intra-abdominal sepsis in rats
55. Treatment of experimental peritonitis in rats by transfer of peritoneal mononuclear cells from rats injected with semisoluble aminated glucan
56. Fibrin in peritonitis. I. Beneficial and adverse effects of fibrin in experimental E. coli peritonitis
57. Peritonitis and septic shock-An evaluation of two experimental models in the rat
58. A new model for studying nutrition in peritonitis
59. Standardized intraabdominal abscess formation with generalized sepsis: Pathophysiology in the rat
60. Increased passage of bovine serum albumin over the respiratory tract after intratracheal instillation during septic shock in rats
61. A selective inhibitor of inducible nitric oxide synthase prolongs survival in a rat model of bacterial peritonitis: Comparison with two nonselective strategies
62. Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
63. Regulation of hepatic protein synthesis in chronic inflammation and sepsis
64. Cardiovascular performance with E. coli challenges in a canine model of human sepsis
65. A porcine model of peritonitis and bacteremia simulates human septic shock
66. Effect of aerosolized fibrin solution on intraperitoneal contamination
67. Antimicrobial therapy of experimental intraabdominal sepsis
68. Effect of carbon dioxide pneumoperitoneum on bacteraemia and endotoxaemia in an animal model of peritonitis
69. Renovascular interaction of epinephrine, dopamine and intraperitoneal sepsis
70. Management of abdominal sepsis
71. Management of secondary peritonitis
72. Lessons from an animal model of intra-abdominal sepsis
73. Porcine peritoneal sepsis: Modeling for clinical relevance
74. Effects of Positive end-expiratory pressure on splanchnic circulation and function in experimental peritonitis
75. Comparison of the efficacy of three different treatments with imipenem versus the classical clindamycin plus tobramycin in experimental peritonitis
76. Pathogenic strategies of enteric bacteria
77. Effect of sepsis on tissue adenine nucleotide levels
78. Triglyceride-rich lipoproteins prevent septic death in rats
79. Intra-abdominal sepsis impairs colonic reparative collagen synthesis
80. Modulation of hemodynamics and organ blood flow by nitric oxide synthase inhibition is not altered in normotensive, septic rat
81. Vascular reactivity in sepsis: Importance of controls and role of nitric oxide
82. The duration of infection modifies mitochondrial oxidative capacity in rat skeletal muscle
83. Initial externalization followed by internalization of β-adrenergic receptors in rat heart during sepsis
84. Alterations of ex vivo vascular reactivity in intraperitoneal sepsis
85. 1-adrenergic receptors in rat liver during sepsis
86. Cyclooxy genase inhibition and vascular reactivity in a rat model of hyperdynamic sepsis
87. Effect of inhibition of NO synthase on vascular reactivity in a rat model of hyperdynamic sepsis
88. Endothelium-dependent relaxation is depressed at the macro-and microcirculatory levels during sepsis
89. Nitric oxide-To block or to enhance its production during sepsis?
90. Weanling and adult rats differ in fatty acid and carnitine metabolism during sepsis
91. Evaluating the role of inducible nitric oxide synthase using a novel and selective inducible nitric oxide synthase inhibitor in septic lung injury produced by cecal ligation and puncture
92. The effect of surgical treatment following peritoneal sepsis on hepatic gene expression
93. Endotoxin inhibitor prevents sepsis-induced alterations in intestinal ion transport
94. Modulation of TNFα and IL-6 in a peritonitis model using Pentoxifylline
95. Impairment of the brain β-adrenergic system during experimental endotoxemia
96. The possible role of a central nervous system dopaminergic mechanism in hepatic c-fos protein expression following peritoneal sepsis
97. Effects of hydroxyethyl starch-deferoxamine on arachidonic acid metabolism and small bowel perfusion in early sepsis
98. Induction of the heat shock response reduces mortalitiy rate and organ damage in a sepsis-induced acute lung injury model
99. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model
100. Enhanced survival from cecal ligation and punctur with pentoxify lline is associated with altered neutrophil trafficking and reduced interleukin-1β expression but not inhibition of tumor necrosis factor synthesis
101. Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge
102. Role of nitric oxide in the failure of neutrophil migration in sepsis
103. Lidocaine attenuates sepsis-induced diaphragmatic dysfunction in hamsters
104. Hypocalcemia during sepsis-Relationship to resuscitation and hemodynamics
105. Oxygen kinetics in experimental sepsis
106. The renal response produced by nonhypotensive sepsis in a large animal model
107. Effects of modest anemia on systemic and coronary circulation of septic sheep
108. Changes in myocardial blood flow rates during hyperdynamic sepsis with induced changes in arterial perfusing pressures and metabolic need
109. Circulatory sequelae of administering CPAP in hyperdynamic sepsis are time dependent
110. Effect of dobutamine on lung microvascular fluid flux in sheep with "sepsis syndrome"
111. Peripheral lymph flow in sheep with bacterial peritonitis: Evidence for increased peripheral microvascular permeability accompanying systemic sepsis
112. Sepsis depresses the metabolic oxygen reserve of the coronary circulation in mature sheep
113. Hematocrit modifies the circulatory control of systemic and myocardial oxygen utilization in septic sheep
114. Hemodynamic, renal and hormonal actions of aprotinin in an ovine model of septic shock
115. Essential role of gamma interferon in survival of colon ascendens stent peritonitis, a novel murine model of abdominal sepsis
116. Role of endotoxin in the expression of endothelial selectins after cecal ligation and perforation
117. Immune depression in polymicrobial sepsis: The role of necrotic (injured) tissue and endotoxin
118. Endotoxin and tumor necrosis factor do not cause mortality from cecal ligation and puncture
119. The inflammatory basis of trauma/shock-associated multiple organ failure
120. Hypertonic saline resuscitation decreases susceptibility to sepsis after hemorrhagic shock
121. Is circulating endotoxin the trigger for the Systemic Inflammatory Response Syndrome seen after injury?
122. Granulocyte macrophage colony-stimulating factor improves survival in two models of gut-derived sepsis by improving gut barrier function and modulating bacterial clearance
123. Donor-specific tolerance permits burn allografting without increased sepsis
124. Polymicrobial sepsis following trauma inhibits interleukin-10 secretion and lymphocyte proliferation
125. Oxygen radical scavenging by ascorbic acid and inhibition of proteinases by aprotinin prevented the neutrophil-associated organ failure-a therapeutic approach
126. Abdominal sepsis following liver resection in the rat
127. Effects of nonanticoagulant heparin on cardiovascular and hepatocellular function after hemorrhagic shock
128. The influence of biliary obstruction and sepsis on reticuloendothelial function in rats
129. Increased intestinal marker absorption due to regional permeability changes and decreased intestinal transit during sepsis in the rat
130. Increased sensitivity to endotoxemia by tissue necrosis
131. Lipopolysaccharide-tumor necrosis factor-glucocorticoid interactions during cecal ligation and puncture-induced sepsis in mature versus senescent mice
132. Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males
133. An evaluation of risk factors for mortality after burn trauma and the identification of gender-dependent differences in outcomes
134. Maintenance of superior mesenteric arterial perfusion prevents increased intestinal mucosal permeability in endotoxic pigs
135. Fluid resuscitation attenuates early cytokine mRNA expression after peritonitis
136. Micro-circulatory changes in rat skeletal muscle in sepsis
137. Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis
138. Histologic and ultrastructural changes in nonpulmonary organs during early hyperdynamic sepsis
139. Renal and cardiovascular response to nonhypotensive sepsis in a large animal model with peritonitis
140. Dantrolene, an inhibitor of intracellular calcium release, fails to increase survival in a rat model of intraabdominal sepsis