A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation

Critical Care Medicine

Volumn 38, Issue 4, 2010, Pages 1092-1100

  Trzeciak, Stephen ^a,b   Jones, Alan E ^c   Shapiro, Nathan I ^d   Pusateri, Anthony E ^e   Arnold, Ryan C ^b   Rizzuto, Michael ^a   Arora, Tanisha ^b   Parrillo, Joseph E ^a   Dellinger, R Phillip ^a  

^a Department of Pediatrics   (United States)

^b Department of Anesthesiology   (United States)

^c CAROLINAS MEDICAL CENTER   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e NOVO NORDISK INC   (United States)

Author keywords

Coagulation; Endothelium; Fibrinolysis; Hemostasis; Hypoxia; Resuscitation; Sepsis; Septic shock; Shock

Indexed keywords

ANTIPLASMIN; ANTITHROMBIN; BIOLOGICAL MARKER; CELL MARKER; D DIMER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRINOGEN; INTERCELLULAR ADHESION MOLECULE 1; LACTIC ACID; OXYGEN; PLASMIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; THROMBIN ANTITHROMBIN COMPLEX; THROMBOMODULIN; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; ARTICLE; BLOOD CLOTTING DISORDER; CENTRAL VENOUS CATHETERIZATION; CENTRAL VENOUS PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; CONTINUOUS CENTRAL VENOUS OXYGEN SATURATION; CONTROLLED STUDY; DISEASE ASSOCIATION; EARLY INTERVENTION; FEMALE; FIBRINOGEN BLOOD LEVEL; HUMAN; HYPOTENSION; HYPOXEMIA; LACTATE BLOOD LEVEL; MALE; MEAN ARTERIAL PRESSURE; MULTICENTER STUDY; OXIMETRY; PARTIAL THROMBOPLASTIN TIME; PATHOGENESIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; RESUSCITATION; SEPSIS; THROMBOCYTE COUNT; VENOUS OXYGEN TENSION;

EID: 77950269260     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181cf6fbc     Document Type: Article

References (34)

1. Dhainaut JF, Shorr AF, Macias WL, et al: Dynamic evolution of coagulopathy in the first day of severe sepsis: Relationship with mortality and organ failure. Crit Care Med 2005; 33:341-348
2. Macias WL, Nelson DR: Severe protein C deficiency predicts early death in severe sepsis. Crit Care Med 2004; 32(5 Suppl):S223-S228
3. Novartis: Tifacogin for the Treatment of Patients with Severe Community-Acquired Pneumonia (NCT00084071). Available at: http://www. clinicaltrials.gov. Accessed February 4, 2009
4. Unfractionated Heparin for the Treatment of Sepsis (NCT00100308). National Library of Medicine. Available at: http://www.clinicaltrials.gov. Accessed February 4, 2009
5. Artisan Pharma, Inc: Safety and Efficacy of ART-123 in Subjects with Sepsis and Disseminated Intravascular Coagulation (NCT00487656). Available at: http://www. clinicaltrials.gov. Accessed February 4, 2009
6. LEO Pharma: Recombinant Human Anti-thrombin in the Treatment of Patients with DIC Associated with Severe Sepsis (NCT00506519). Available at: http://www. clinicaltrials.gov. Accessed February 4, 2009
7. Bernard GR, Vincent JL, Laterre PF, et al: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709
8. Aird WC: Vascular bed-specific hemostasis: Role of endothelium in sepsis pathogenesis. Crit Care Med 2001; 29(7 Suppl):S28-S34
9. Jones AE, Brown MD, Trzeciak S, et al: The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: A meta-analysis. Crit Care Med 2008; 36:2734-2739
10. Rivers E, Nguyen B, Havstad S, et al: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377
11. Rivers EP, Kruse JA, Jacobsen G, et al: The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock. Crit Care Med 2007; 35: 2016-2024
12. Ten VS, Pinsky DJ: Endothelial response to hypoxia: Physiologic adaptation and pathologic dysfunction. Curr Opin Crit Care 2002; 8:242-250
13. Karimova A, Pinsky DJ: The endothelial response to oxygen deprivation: biology and clinical implications. Intensive Care Med 2001; 27:19-31
14. Rivers EP, Ander DS, Powell D: Central venous oxygen saturation monitoring in the critically ill patient. Curr Opin Crit Care 2001; 7:204-211
15. Levy MM, Fink MP, Marshall JC, et al: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003; 29:530-538
16. Jones AE, Focht A, Horton JM, et al: Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock. Chest 2007; 132:425-432
17. Shapiro NI, Howell MD, Talmor D, et al: Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med 2006; 34:1025-1032
18. Trzeciak S, Dellinger RP, Abate NL, et al: Translating research to clinical practice: A 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Chest 2006; 129: 225-232
19. Arnold RC, Shapiro NI, Jones AE, et al: Multi-center study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock 2008; 32:35-39
20. Dellinger RP, Carlet JM, Masur H, et al: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873
21. Reinhart K, Kuhn HJ, Hartog C, et al: Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill. Intensive Care Med 2004; 30: 1572-1578
22. Mavrommatis AC, Theodoridis T, Economou M, et al: Activation of the fibrinolytic system and utilization of the coagulation inhibitors in sepsis: Comparison with severe sepsis and septic shock. Intensive Care Med 2001; 27: 1853-1859
23. Collins PW, Macchiavello LI, Lewis SJ, et al: Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls. Br J Haematol 2006; 135: 220-227
24. Gando S, Kameue T, Matsuda N, et al: Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation. Thromb Res 2005; 116:91-100
25. Taylor FB Jr, Toh CH, Hoots WK, et al: Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001; 86:1327-1330
26. Pinsky DJ, Liao H, Lawson CA, et al: Coordinated induction of plasminogen activator in-hibitor-1 (PAI-1) and inhibition of plasmin-ogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. J Clin Invest 1998; 102:919-928
27. Yan SB, Helterbrand JD, Hartman DL, et al: Low levels of protein C are associated with poor outcome in severe sepsis. Chest 2001; 120:915-922
28. Aird WC: The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003; 101:3765-3777
29. Ogawa S, Koga S, Kuwabara K, et al: Hy-poxia-induced increased permeability of en-dothelial monolayers occurs through lowering of cellular cAMP levels. Am J Physiol 1992; 262(3 Pt 1):C546-C554
30. Ogawa S, Gerlach H, Esposito C, et al: Hyp-oxia modulates the barrier and coagulant function of cultured bovine endothelium. Increased monolayer permeability and induction of procoagulant properties. J Clin Invest 1990; 85:1090-1098
31. Lawson CA, Yan SD, Yan SF, et al: Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation. J Clin Invest 1997; 99:1729-1738
32. Healy AM, Hancock WW, Christie PD, et al: Intravascular coagulation activation in a mu-rine model of thrombomodulin deficiency: Effects of lesion size, age, and hypoxia on fibrin deposition. Blood 1998; 92:4188-4197
33. James JH, Luchette FA, McCarter FD, et al: Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet 1999; 354:505-508
34. Luchette FA, Jenkins WA, Friend LA, et al: Hypoxia is not the sole cause of lactate production during shock. J Trauma 2002; 52: 415-419