Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Lamoke, Folami ^a   Mazzone, Valeria ^b   Persichini, Tiziana ^b   Maraschi, Annamaria ^c   Harris, Brennan M ^d   Venema, Richard C ^a   Colasanti, Marco ^b   Gliozzi, Micaela ^e   Muscoli, Carolina ^e,f   Bartoli, Manuela ^a   Mollace, Vincenzo ^e,f  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b ROMA TRE UNIVERSITY   (Italy)

^c ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^d Dept of Economics and Thomas Jefferson Program in Public Policy at the College of William and Mary   (United States)

^e Department of Pharmacobiological Sciences   (Italy)

^f IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AMYLOID BETA PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 90; NITRIC OXIDE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SERINE; VASCULOTROPIN; SCAVENGER; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BOVINE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IMMUNOPRECIPITATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN INTERACTION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; DRUG INTERACTION; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ACETYLCYSTEINE; AMYLOID BETA-PEPTIDES; ANIMALS; CATTLE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; HSP90 HEAT-SHOCK PROTEINS; IMMUNOPRECIPITATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84929429298     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0304-x     Document Type: Article

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