Optical imaging in an Alzheimer's mouse model reveals amyloid-β-dependent vascular impairment

Neurophotonics

Volumn 1, Issue 1, 2014, Pages

  Lin, Alexander J ^a,b   Liu, Gangjun ^a   Castello, Nicholas A ^b,c   Yeh, James J ^a   Rahimian, Rombod ^a   Lee, Grace ^a   Tsay, Victoria ^a   Durkin, Anthony J ^a   Choi, Bernard ^a,b   Laferla, Frank M ^b,c   Chen, Zhongping ^a,b   Green, Kim N ^b,c   Tromberg, Bruce J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

absorption; diffuse optical spectroscopy; Doppler optical coherence tomography; hypercapnia; microvascular perfusion; neuroimaging; scattering; spatial frequency domain imaging; vascular reactivity

Indexed keywords

ABSORPTION; COHERENT SCATTERING; ENDOTHELIAL CELLS; FREQUENCY DOMAIN ANALYSIS; HEMOGLOBIN; IMAGING TECHNIQUES; MAMMALS; NEURODEGENERATIVE DISEASES; NEUROIMAGING; NITRIC OXIDE; OPTICAL IMAGE STORAGE; OPTICAL TOMOGRAPHY; SCATTERING; TOMOGRAPHY;

DIFFUSE OPTICAL SPECTROSCOPY; DOPPLER OPTICAL COHERENCE TOMOGRAPHY; HYPERCAPNIA; MICROVASCULAR; SPATIAL FREQUENCY DOMAIN IMAGING;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; OXYHEMOGLOBIN; VASCULOTROPIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN BLOOD VESSEL; BRAIN HISTOLOGY; BRAIN TISSUE; CAPILLARY DENSITY; CEREBROVASCULAR DISEASE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIAGNOSTIC IMAGING; FLUORESCENCE IMAGING; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HYPERCAPNIA; IMMUNOHISTOCHEMISTRY; MOUSE; MULTIMODAL IMAGING; NEUROIMAGING; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; OXYGEN SATURATION; PROTEIN EXPRESSION; SPATIAL FREQUENCY DOMAIN IMAGING; VASODILATATION;

EID: 84978926995     PISSN: 2329423X     EISSN: 23294248     Source Type: Journal    
DOI: 10.1117/1.NPh.1.1.011005     Document Type: Article

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