Just say NO: Nitric oxide regulation of Hsp90

EMBO Reports

Volumn 10, Issue 10, 2009, Pages 1093-1094

  Scroggins, Bradley T ^a   Neckers, Len ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; NITRIC OXIDE; NOVOBIOCIN;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; DIMERIZATION; EUKARYOTE; HUMAN; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WILD TYPE;

ADENOSINE TRIPHOSPHATASES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; SACCHAROMYCES CEREVISIAE;

EID: 70449716951     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.212     Document Type: Article

References (13)

1. Fontana J, Fulton D, Chen Y, Fairchild TA, McCabe TJ, Fujita N, Tsuruo T, Sessa WC (2002) Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and No release. Circ Res 90: 866-873
2. Garcia-Cardena G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC (1998) Dynamic activation of enclothelial nitric oxide synthase by Hsp90. Nature 392: 821-824
3. Graf C, Stankiewicz M, Kramer G, Mayer MP (2009) Spatially and kinetically resolved changes in the conformational dynamics of the Hsp90 chaperone machine. EMB0 J 28: 602-613
4. Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS (2005) Protein S-nitrosylation: Purview and parameters. Nat Rev Mol Biol 6: 150-166
5. Huerta S, Chilka S, Bonavida B (2008) Nitric oxide donors: Novel cancer therapeutics (review). Int J Oncol 33: 909-927
6. Martinez-Ruiz A, Villanueva L, Gonzalez de Orduna C, Lopez-Ferrer D, Higueras MA, Tarin C, Rodriguez-Crespo I, Vazquez J, Lamas S (2005) S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. Proc Natl Acad Sci USA 102: 8525-8530
7. Morra G, Verkhivker G, Colombo G (2009) Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimer. PLoS Comput Biol 5: e1000323
8. Pearl LH, Prodromou C (2006) Structure and mechanism of the Hsp90 molecular chaperone machinery. Annu Rev Biochem 75: 271-294
9. Peng HM, Morishima Y, Clapp KM, Lau M, Pratt WB, Osawa Y (2009) Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. Biochemistry [published online, 30 July] doi:10.1021/bi901058g
10. Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH (1997) Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell 90: 65-75
11. Retzlaff M, Stahl M, Eberl HC, Lagleder S, Beck J, Kessler H, Buchner J (2009) Hsp90 is regulated by a switch point in the C-terminal domain. EMBO Rep 10: 1147-1153
12. Scroggins BT, Neckers L (2007) Post-translational modification of heat-shock protein 90: Impact on chaperone function. Expert Opin Drug Discov 2: 1403-1414
13. Yoshida M, Xia Y (2003) Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase. J Biol Chem 278 36953-36958