PH-sensitive poly(lactide-co-glycolide) nanoparticle composite microcapsules for oral delivery of insulin

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 3489-3498

  Sun, Shaoping ^a   Liang, Na ^b   Yamamoto, Hiromitsu ^c   Kawashima, Yoshiaki ^c   Cui, Fude ^d   Yan, Pengfei ^a  

^a HEILONGJIANG UNIVERSITY   (China)

^b HARBIN NORMAL UNIVERSITY   (China)

^c AICHI GAKUIN UNIVERSITY   (Japan)

^d SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Complex; Eudragit FS 30D; PLGA nanoparticles; Sodium oleate

Indexed keywords

EUDRAGIT; INSULIN; NANOPARTICLE; OLEATE SODIUM; POLYGLACTIN; DRUG CARRIER; LACTIC ACID; MICROCAPSULE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; EMULSION; GASTROINTESTINAL TRACT; GLUCOSE BLOOD LEVEL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; ION PAIR EXTRACTION; MALE; MICROCAPSULE; NONHUMAN; PARTICLE SIZE; PH; RAT; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; ZETA POTENTIAL; ADMINISTRATION AND DOSAGE; ANIMAL; CHEMISTRY; ORAL DRUG ADMINISTRATION; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; CAPSULES; DRUG CARRIERS; INSULIN; LACTIC ACID; MALE; NANOPARTICLES; POLYGLYCOLIC ACID; RATS; RATS, WISTAR;

EID: 84929414399     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S81715     Document Type: Article

References (32)

1. Song L, Zhi ZL, Pickup JC. Nanolayer encapsulation of insulin-chitosan complexes improves efficiency of oral insulin delivery. Int J Nanomedi-cine. 2014;9:2127–2136.
2. Sonia TA, Sharma CP. An overview of natural polymers for oral insulin delivery. Drug Discov Today. 2012;17(13–14):784–792.
3. Arbit E, Kidron M. Oral insulin: the rationale for this approach and current developments. J Diabetes Sci Technol. 2009;3(3):562–567.
4. Arbit E. The physiological rationale for oral insulin administration. Diabetes Technol Ther. 2004;6(4):510–517.
5. Sonaje K, Lin KJ, Wey SP, et al. Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH-responsive nanoparticles vs subcutaneous injection. Bioma-terials. 2010;31(26):6849–6858.
6. Lewis GF, Zinman B, Groenewoud Y, Vranic M, Giacca A. Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. Diabetes. 1996;45(4):454–462.
7. Damgé C, Maincent P, Ubrich N. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J Control Release. 2007;117(2): 163–170.
8. Chaturvedi K, Ganguly K, Nadagouda MN, Aminabhavi TM. Polymeric hydrogels for oral insulin delivery. J Control Release. 2013;165(2): 129–138.
9. Sullivan CO, Birkinshaw C. In vitro degradation of insulin-loaded poly(n-butylcyanoacrylate) nanoparticles. Biomaterials. 2004;25(18): 4375–4382.
10. Yun Y, Cho YW, Park K. Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery. Adv Drug Deliv Rev. 2013;65(6):822–832.
11. Maroni A, Zema L, Del Curto MD, Foppoli A, Gazzaniga A. Oral colon delivery of insulin with the aid of functional adjuvants. Adv Drug Deliv Rev. 2012;64(6):540–556.
12. Li X, Guo S, Zhu C, et al. Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles. Biomaterials. 2013;34(37):9678–9687.
13. Soares S, Costa A, Sarmento B. Novel non-invasive methods of insulin delivery. `Expert Opin Drug Deliv. 2012;9(12):1539–1558.
14. Mukhopadhyay P, Mishra R, Rana D, Kundu PP. Strategies for effective oral insulin delivery with modifed chitosan nanoparticles: a review. Prog Polym Sci. 2012;37(11):1457–1475.
15. Sun S, Liang N, Kawashima Y, Xia D, Cui F. Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin. Int J Nanomedicine. 2011;6:3049–3056.
16. Sun S, Liang N, Piao H, Yamamoto H, Kawashima Y, Cui F. Insulin-S.O (sodium oleate) complex-loaded PLGA nanoparticles: formulation, characterization and in vivo evaluation. J Microencapsul. 2010;27(6):471–478.
17. Quintanar-Guerrero D, Allémann E, Fessi H, Doelker E. Applications of the ion-pair concept to hydrophilic substances with special emphasis on peptides. Pharm Res. 1997;14(2):119–127.
18. Meyer JD, Manning MC. Hydrophobic ion pairing: altering the solubility properties of biomolecules. Pharm Res. 1998;15(2):188–193.
19. Kshirsagar SJ, Bhalekar MR, Umap RR. In vitro in vivo comparison of two pH sensitive Eudragit polymers for colon specific drug delivery. J Pharm Sci Res. 2009;1(4):61–70.
20. Damgé C, Michel C, Aprahamian M, Couvreur P. New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier. Diabetes. 1988;37(2):246–251.
21. Vandamme TF, Lenourry A, Charrueau C, Chaumeil JC. The use of polysaccharides to target drugs to the colon. Carbohydr Polym. 2002; 48:219–231.
22. Maroni A, Del Curto MD, Serratoni M, et al. Feasibility, stability and release performance of a time-dependent insulin delivery system intended for oral colon release. Eur J Pharm Biopharm. 2009;72(1):246–251.
23. Lopes MA, Abrahim BA, Cabral LM, et al. Intestinal absorption of insulin nanoparticles: contribution of M cells. Nanomedicine. 2014;10(6):1139–1151.
24. Takenaga M, Yamaguchi Y, Kitagawa A, et al. Optimum formulation for sustained-release insulin. Int J Pharm. 2004;271(1–2):85–94.
25. Hofmann C, Goldfne ID, Whittaker J. The metabolic and mitogenic effects of both insulin and insulin-like growth factor are enhanced by transfection of insulin receptors into NIH3T3 fibroblasts. J Biol Chem. 1989;264(15):8606–8611.
26. Ziv E, Bendayan M. Intestinal absorption of peptides through the entero-cytes. Microsc Res Tech. 2000;49(4):346–352.
27. Wissing SA, Kayser O, Müller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev. 2004;56(9): 1257–1272.
28. Sarmento B, Martins S, Ferreira D, Souto EB. Oral insulin delivery by means of solid lipid nanoparticles. Int J Nanomedicine. 2007;2(4): 743–749.
29. Hu FQ, Yuan H, Zhang HH, Fang M. Preparation of solid lipid nano-particles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int J Pharm. 2002;239(1–2):121–128.
30. Cui FD, Tao AJ, Cun DM, Zhang LQ, Shi K. Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. J Pharm Sci. 2007; 96(2):421–427.
31. Yo o MK, Kang SK, Choi JH, et al. Targeted delivery of chitosan nanoparticles to Peyer’s patch using M cell-homing peptide selected by phage display technique. Biomaterials. 2010;31(30):7738–7747.
32. Wang XQ, Zhang Q. pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs. Eur J Pharm Biopharm. 2012;82(2):219–229.