Nanolayer encapsulation of insulin- chitosan complexes improves efficiency of oral insulin delivery

International Journal of Nanomedicine

Volumn 9, Issue 1, 2014, Pages 2127-2136

  Song, Lei ^a   Zhi, Zheng Liang ^a   Pickup, John C ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

Chitosan; Diabetes mellitus; Heparin; Insulin chitosan complexes; Multilayer nanoencapsulation; Oral insulin; Polyethylene glycol

Indexed keywords

CHITOSAN; GLUCOSE; MACROGOL 6000; RECOMBINANT HUMAN INSULIN; STREPTOZOCIN; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; INSULIN; NANOCAPSULE; NANOCOMPOSITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INTESTINE ABSORPTION; MALE; MOUSE; NANOENCAPSULATION; NONHUMAN; PH; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SUSTAINED DRUG RELEASE; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DIFFUSION; GASTROINTESTINAL ABSORPTION; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; ORAL DRUG ADMINISTRATION; TREATMENT OUTCOME; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CHITOSAN; DIABETES MELLITUS, EXPERIMENTAL; DIFFUSION; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICE, INBRED ICR; NANOCAPSULES; NANOCOMPOSITES; ORAL MUCOSAL ABSORPTION; STREPTOZOCIN; TREATMENT OUTCOME;

EID: 84899821738     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S59075     Document Type: Article

References (37)

1. Owens DR. New horizons-alternative routes for insulin therapy. Nat Rev Drug Discov. 2002;1(7):529-540.
2. Heinemann L, Jacques Y. Oral insulin and buccal insulin: a critical reappraisal. J Diabetes Sci Technol. 2009;3(3):568-584.
3. Sajeesh S, Sharma CP. Novel pH responsive polymethacrylic acid-chitosan-polyethylene glycol nanoparticles for oral peptide delivery. J Biomed Mater Res B Appl Biomater. 2006;76(2):298-305.
4. Cui F, Qian F, Zhao Z, Yin L, Tang C, Yin C. Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly(methyl methacrylate) nanoparticles. Biomacromolecules. 2009;10(5):1253-1258.
5. Sarmento B, Ribeiro A, Veiga F, Ferreira D, Neufeld R. Oral bioavailability of insulin contained in polysaccharide nanoparticles. Biomacromolecules. 2007;8(10):3054-3060.
6. Reis CP, Veiga FJ, Ribeiro AJ, Neufeld RJ, Damgé C. Nanoparticulate biopolymers deliver insulin orally eliciting pharmacological response. J Pharm Sci. 2008;97(12):5290-5305.
7. Sarmento B, Ribeiro A, Veiga F, Sampaio P, Neufeld R, Ferreira D. Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm Res. 2007;24(12):2198-2206.
8. Sonaje K, Lin YH, Juang JH, Wey SP, Chen CT, Sung HW. In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials. 2009;30(12):2329-2339.
9. Lin YH, Chen CT, Liang HF, etal. Novel nanoparticles for oral insulin delivery via the paracellular pathway. Nanotechnology. 2007;18(10):1-11.
10. Woitiski CB, Neufeld RJ, Veiga F, Carvalho RA, Figueiredo IV. Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles. Eur J Pharm Sci. 2010;41(3-4): 556-563.
11. Zheng J, Yue X, Dai Z, Wang Y, Liu S, Yan X. Novel iron-polysaccharide multilayered microcapsules for controlled insulin release. Acta Biomater. 2009;5(5):1499-1507.
12. Niu M, Lu Y, Hovgaard L, etal. Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose. Eur J Pharm Biopharm. 2012;81(2):265-272.
13. Carvalho EL, Grenha A, Remuñán-López C, Alonso MJ, Seijo B. Mucosal delivery of liposome-chitosan nanoparticle complexes. Methods Enzymol. 2009;465:289-312.
14. Moutinho CG, Matos CM, Teixeira JA, Balcão VM. Nanocarrier possibilities for functional targeting of bioactive peptides and proteins: state-of-the-art. J Drug Target. 2012;20(2):114-141.
15. Wong TW. Chitosan and its use in design of insulin delivery system. Recent Pat Drug Deliv Formul. 2009;3(1):8-25.
16. Chaudhury A, Das S. Recent advancement of chitosan-based nanoparticles for oral controlled delivery of insulin and other therapeutic agents. AAPS Pharm Sci Tech. 2011;12(1):10-20.
17. Hamman JH. Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems. Mar Drugs. 2010;8(4): 1305-1322.
18. Teply BA, Tong R, Jeong SY, etal. The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules. Biomaterials. 2008;29(9): 1216-1223.
19. 2+, cyclic AMP, a phorbol ester and noradrenaline. Biochem J. 1988;254(2):397-403.
20. El-Shabouri MH. Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A. Int J Pharm. 2002;249(1-2): 101-108.
21. Sukhorukova GB, Donath E, Lichtenfeld H, etal. Layer-by-layer self-assembly of polyelectrolytes on colloidal particles. Colloids Surfaces A: Physicochem Eng Aspects. 1998;137:253-266.
22. Decher G. Fuzzy nanoassemblies: toward layered polymeric multicomposites. Science. 1997;277:1232-1237.
23. Matsusaki M, Ajiro H, Kida T, Serizawa T, Akashi M. Layer-by-layer assembly through weak interactions and their biomedical applications. Adv Mater. 2012;24(4):454-474.
24. de Villiers MM, Otto DP, Strydom SJ, Lvov YM. Introduction to nanocoatings produced by layer-by-layer (LbL) self-assembly. Adv Drug Deliv Rev. 2011;63(9):701-715.
25. Ai H, Jones SA, de Villiers MM, Lvov YM. Nano-encapsulation of furosemide microcrystals for controlled drug release. J Control Release. 2003;86(1):59-68.
26. Shenoy DB, Sukhorukov GB. Engineered microcrystals for direct surface modification with layer-by-layer technique for optimized dissolution. Eur J Pharm Biopharm. 2004;58(3):521-527.
27. Hoogeveen NG, Stuart MAC, Fleer GJ, Böhmer MR. Formation and stability of multilayers of polyelectrolytes. Langmuir. 1996;12: 3675-3681.
28. Zhi ZL, Kerby A, King AJ, Jones PM, Pickup JC. Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes. Diabetologia. 2012;55(4): 1081-1090.
29. Zhi ZL, Haynie DT. High-capacity functional protein encapsulation in nanoengineered polypeptide microcapsules. Chem Commun (Camb). 2006;(2):147-149.
30. Zhi ZL, Haynie DT. Straightforward and effective protein encapsulation in polypeptide-based artificial cells. Artif Cells Blood Substit Immobil Biotechnol. 2006;34(2):189-203.
31. Palath N, Bhad S, Montazeri R, Guidry CA, Haynie DT. Polypeptide multilayer nanofilm artificial red blood cells. J Biomed Mater Res B Appl Biomater. 2007;81(1):261-268.
32. Ma Z, Lim TM, Lim LY. Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats. Int J Pharm. 2005;293(1-2): 271-280.
33. Pan Y, Li YJ, Zhao HY, etal. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm. 2002;249(1-2):139-147.
34. Knop K, Hoogenboom R, Fischer D, Schubert US. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew Chem Int Ed Engl. 2010;49(36):6288-6308.
35. Rinaudo M. Chitin and chitosan: properties and applications. Prog Polymer Sci. 2006;31:603-632.
36. Reis CP, Figueiredo IV, Carvalho RA, etal. Toxicological assessment of orally delivered nanoparticulate insulin. Nanotoxicology. 2008;2:205-217.
37. Mukhopadhyay P, Mishra R, Rana D, Kundu PP. Strategies for effective oral insulin delivery with modified chitosan nanoparticles: a review. Prog Polymer Sci. 2012;37:1457-1475.