Polyacrylic acid polymers hydrogels intended to topical drug delivery: Preparation and characterization

Pharmaceutical Development and Technology

Volumn 20, Issue 4, 2015, Pages 490-496

  Calixto, Giovana ^a   Yoshii, Ana Carolina ^a   Rocha E Silva, Hilris ^a   Stringhetti Ferreira Cury, Beatriz ^a   Chorilli, Marlus ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Bioadhesion; Hydrogel; Metronidazole; Polyacrylic acid polymers; Topical drug delivery system

Indexed keywords

CARBOMER; METRONIDAZOLE; POLYACRYLIC ACID; POLYCARBOPHIL; ACRYLIC ACID RESIN; ANTIINFECTIVE AGENT; CARBOPOL 940; DELAYED RELEASE FORMULATION; HYDROGEL;

ADHESION; ARTICLE; COMPRESSION; DIFFUSION; DISPERSION; DRUG DELIVERY SYSTEM; HARDNESS; HYDROGEL; IN VITRO STUDY; PRIORITY JOURNAL; SHEAR RATE; SHEAR STRESS; SUSTAINED DRUG RELEASE; THIXOTROPY; TOPICAL DRUG DELIVERY; CHEMISTRY; DELAYED RELEASE FORMULATION; FLOW KINETICS; TOPICAL DRUG ADMINISTRATION;

ACRYLIC RESINS; ADHESIVENESS; ADMINISTRATION, TOPICAL; ANTI-INFECTIVE AGENTS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; HARDNESS; HYDROGELS; METRONIDAZOLE; RHEOLOGY;

EID: 84929391329     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2014.882941     Document Type: Article

References (48)

1. Agnihotri SA, Jawalkar SS, Aminabhavi TM. Controlled release of cephalexin through gellan gum beads: effect of formulation parameters on entrapment efficiency, size, and drug release. Eur J Pharm Biopharm 2006;63:249-261.
2. Kehr NS, Prasetyanto EA, Benson K, et al. Periodic mesoporous organosilica-based nanocomposite hydrogels as three-dimensional scaffolds. Angew Chem Int Ed 2013;52:1156-1160.
3. López-Cebral R, Paolicelli P, Romero-Caamanõ V, et al. Spermidine-cross-linked hydrogels as novel potential platforms for pharmaceutical applications. J Pharm Sci 2013;102:2632-2643.
4. Malana MA, Zohra R. The release behavior and kinetic evaluation of tramadol HCl from chemically cross linked Ter polymeric hydrogels. DARU J Pharm Sci 2013;21:10. doi: 10.1186/2008-2231-21-10
5. Carvalho FC, Calixto G, Hatakeyama IN, et al. Rheological, mechanical, and bioadhesive behavior of hydrogels to optimize skin delivery systems. Drug Dev Ind Pharm 2012;39:1750-1757.
6. Borde A, Bergstrand A, Gunnarsson C, Larsson A. Osmotic-driven mass transport of water: impact on the adhesiveness of hydrophilic polymers. J Colloid Interface Sci 2010;341:255-260.
7. Can AS, Erdal MS, Güngör S, Ö zsoy Y. Optimization and characterization of chitosan films for transdermal delivery of ondansetron. Molecules 2013;18:5455-5471.
8. Raj Singh TR, Woolfson AD, Donnelly RF. Investigation of solute permeation across hydrogels composed of poly(methyl vinyl etherco-maleic acid) and poly(ethylene glycol). J Pharm Pharmacol 2010; 62:829-837.
9. Suresh P, Manasa K, Babu SS, et al. Bioadhesive drug delivery system-A review. Asian J Pharm Res Vol 2013;3:30-37.
10. Roy S, Prabhakar B. Bioadhesive polymeric platforms for transmucosal drug delivery systems-A review. Trop J Pharm Res 2010;9:91-104.
11. Gupta P, Vermani K, Garg S. Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discov Today 2002;7:569-579.
12. Bakhru SH, Furtado S, Morello AP, Mathiowitz E. Oral delivery of proteins by biodegradable nanoparticles. Adv Drug Deliver Rev 2013;65:811-821.
13. Matricardi P, Di Meo C, Coviello T, et al. Interpenetrating polymer networks polysaccharide hydrogels for drug delivery and tissue engineering. Adv Drug Deliver Rev 2013;65:1172-1187.
14. Wiltsey C, Kubinski P, Christiani T, et al. Characterization of injectable hydrogels based on poly(N-isopropylacrylamide)-g-chondroitin sulfate with adhesive properties for nucleus pulposus tissue engineering. J Mater Sci: Mater Med 2013;24:837-847.
15. Mahajan P, Kaur A, Aggarwal G, Harikumar S. Mucoadhesive drug delivery system: A review. Int J Drug Dev Res 2013;5:11-20.
16. Tsibouklis J, Middleton AM, Patel N, Pratten J. Toward mucoadhesive hydrogel formulations for the management of xerostomia: The physicochemical, biological, and pharmacological considerations. J Biomed Mater Res A 2013;101:3327-3338.
17. Lee KY, Mooney DJ. Alginate: properties and biomedical applications. Prog Polym Sci 2012;37:106-126.
18. Gomez C, Blanco M, Bernardo M, et al. Poly (acrylamide-comonoethyl itaconate) hydrogels as devices for cytarabine release in rats. J Pharm Pharmacol 1998;50:703-712.
19. Mironescu M, Mironescu ID. Rheological behaviour of a novel microbial polysaccharide. Rom Biotechnol Lett 2011;16:6105-6114.
20. Hurler J, Engesland A, Poorahmary Kermany B, Škalko-Basnet N. Improved texture analysis for hydrogel characterization: gel cohesiveness, adhesiveness, and hardness. J Appl Polym Sci 2012;125: 180-188.
21. Bruschi ML, Jones DS, Panzeri H, et al. Semisolid systems containing propolis for the treatment of periodontal disease: in vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties. J Pharm Sci 2007;96:2074-2089.
22. Perioli L, Ambrogi V, Rubini D, et al. Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease. J Control Release 2004;95:521-533.
23. Pál S, Nagy S, Bozó T, et al. Technological and biopharmaceutical optimization of nystatin release from a multiparticulate based bioadhesive drug delivery system. Eur J Pharm Sci 2013;49: 258-264.
24. Zip CM. Innovative use of topical metronidazole. Dermatol Clin 2010;28:525-534.
25. Rao M, Sukre G, Aghav S, Kumar M. Optimization of metronidazole emulgel. J Pharm 2013;2013:article ID 501082.
26. Gao P, Nie X, Zou M, et al. Recent advances in materials for extended-release antibiotic delivery system. J Antibiot 2011;64: 625-634.
27. Joshi M, Patravale V. Formulation and evaluation of nanostructured lipid carrier (NLC)-based gel of valdecoxib. Drug Dev Ind Pharm 2006;32:911-918.
28. Soares GA, Castro ADd, Cury BSF, Evangelista RC. Blends of cross-linked high amylose starch/pectin loaded with diclofenac. Carbohydr Polym 2013;91:135-142.
29. Balcárková J, Carvalho FC, Ferrari PC, et al. Chitosan/carbomerbased tablets containing metronidazole for potential treatment of periodontal diseases. J Pharm Res 2012;5:3339-3342.
30. Savic S, Lukic M, Jaksic I, et al. An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential. J Colloid Interface Sci 2011;358:182-191.
31. Prestes PS, Chorilli M, Chiavacci LA, et al. Physicochemical characterization and rheological behavior evaluation of the liquid crystalline mesophases developed with different silicones. J Dispers Sci Technol 2009;31:117-123.
32. Laba D. Rheological properties of cosmetics and toiletries: CRC PressI Llc. New York: Marcel Dekker; 1993.
33. Fresno Contreras M, Ramírez Diéguez A, Jiménez Soriano M. Rheological characterization of hydroalcoholic gels-15% ethanol-of Carbopol Ultrez 10. Il Farmaco 2001;56:437-441.
34. Pereira RR, Ribeiro Godoy JS, Stivalet Svidzinski TI, Bruschi ML. Preparation and characterization of mucoadhesive thermoresponsive systems containing propolis for the treatment of vulvovaginal candidiasis. J Pharm Sci 2013;102:1222-1234.
35. Carvalho FC, da Luz GM, da Silva Barbi M, et al. Rheological, mechanical and adhesive properties of surfactant-containing systems designed as a potential platform for topical drug delivery. J Biomed Nanotechnol 2012;8:280-289.
36. Carvalho FC, Sarmento VH, Chiavacci LA, et al. Development and in vitro evaluation of surfactant systems for controlled release of zidovudine. J Pharm Sci 2010;99:2367-2374.
37. Haminiuk CWI, Sierakowski M-R, Izidoro DR, et al. Rheological behavior of pectic systems of red fruit pulps. Ciênc Tecnol Aliment 2009;29:225-231.
38. Song K-W, Kim Y-S, Chang G-S. Rheology of concentrated xanthan gum solutions: steady shear flow behavior. Fibers Polym 2006;7: 129-138.
39. A-sasutjarit R, Sirivat A, Vayumhasuwan P. Viscoelastic properties of Carbopol 940 gels and their relationships to piroxicam diffusion coefficients in gel bases. Pharm Res 2005;22:2134-2140.
40. Islam MT, Rodríguez-Hornedo N, Ciotti S, Ackermann C. Rheological characterization of topical carbomer gels neutralized to different pH. Pharm Res 2004;21:1192-1199.
41. Chiou B-S, English RJ, Khan SA. Rheology and photo-cross-linking of thiol-ene polymers. Macromolecules 1996;29:5368-5374.
42. Andrews GP, Gorman SP, Jones DS. Rheological characterisation of primary and binary interactive bioadhesive gels composed of cellulose derivatives designed as ophthalmic viscosurgical devices. Biomaterials 2005;26:571-580.
43. Senyiʇit T, Tekmen I, Sönmez Ü , et al. Deoxycholate hydrogels of betamethasone-17-valerate intended for topical use: in vitro and in vivo evaluation. Int J Pharm 2011;403:123-129.
44. Jones DS, Woolfson AD, Brown AF, O'Neill MJ. Mucoadhesive, syringeable drug delivery systems for controlled application of metronidazole to the periodontal pocket: in vitro release kinetics, syringeability, mechanical and mucoadhesive properties. J Control Release 1997;49:71-79.
45. Lee JW, Park JH, Robinson JR. Bioadhesive-based dosage forms: The next generation. J Pharm Sci 2000;89:850-866.
46. Bruschi ML, de Freitas O. Oral bioadhesive drug delivery systems. Drug Dev Indus Pharm 2005;31:293-310.
47. Xu X, Weng Y, Xu L, Chen H. Sustained release of avastin from polysaccharides cross-linked hydrogels for ocular drug delivery. Int J Biol Macromol 2013;60:272-276.
48. Wang C-H, Hwang Y-S, Chiang P-R, et al. Extended release of bevacizumab by thermosensitive biodegradable and biocompatible hydrogel. Biomacromolecules 2011;13:40-48.