Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents

Journal of Medicinal Chemistry

Volumn 57, Issue 5, 2014, Pages 2091-2106

  Leivers, Anna L ^a   Tallant, Matthew ^a   Shotwell, J Brad ^a   Dickerson, Scott ^a   Leivers, Martin R ^a   McDonald, Octerloney B ^a   Gobel, Jeff ^a   Creech, Katrina L ^a   Strum, Susan L ^a   Mathis, Amanda ^a,b   Rogers, Sabrinia ^a   Moore, Chris B ^a   Botyanszki, Janos ^a  

^a GLAXOSMITHKLINE   (United States)

^b Salix a Division of Valeant Pharmaceuticals North America LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; PHOSPHATIDYLINOSITOL 4 KINASE 3 ALPHA; PHOSPHATIDYLINOSITOL 4 KINASE 3 ALPHA INHIBITOR; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOTRANSFERASE INHIBITOR; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HEPATITIS C VIRUS; HIGH THROUGHPUT SCREENING; IC 50; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; MOLECULE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION; VIRUS REPLICATION; VIRUS STRAIN;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANIMALS; ANTIVIRAL AGENTS; DRUG DISCOVERY; ENZYME INHIBITORS; HEPACIVIRUS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84894662129     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400781h     Document Type: Article

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