Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels

Journal of Biological Chemistry

Volumn 289, Issue 9, 2014, Pages 6120-6132

  Bojjireddy, Naveen ^a   Botyanszki, Janos ^b   Hammond, Gerald ^a   Creech, Donald ^b   Peterson, Richard ^b   Kemp, Daniel C ^b   Snead, Mark ^b   Brown, Randy ^b   Morrison, Alastair ^b   Wilson, Steve ^b   Harrison, Steve ^b   Moore, Chris ^b   Balla, Tamas ^a,c  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b GLAXOSMITHKLINE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOPLASMIC RETICULUM; PHARMACOLOGICAL BLOCKADE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATES; PHOSPHOINOSITIDES; PHOSPHOLIPASE C ACTIVATIONS; THERAPEUTIC TARGETS;

ENZYMES; PHOSPHOLIPIDS; VIRUSES;

CELL MEMBRANES;

PHOSPHATIDYLINOSITOL 4 KINASE TYPE III ALPHA; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOLIPASE C; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; FEMALE; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; INTESTINE NECROSIS; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; SUDDEN DEATH;

ANGIOTENSIN II; G PROTEIN-COUPLED RECEPTORS; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOLIPASE C;

ANIMALS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; GENE TARGETING; HEK293 CELLS; HEPATITIS C; HUMANS; MICE; MICE, TRANSGENIC; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); TYPE C PHOSPHOLIPASES;

EID: 84896878284     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.531426     Document Type: Article

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