Immunization with a myelin-derived antigen activates the brain’s choroid plexus for recruitment of immunoregulatory cells to the CNS and attenuates disease progression in a mouse model of ALS

Journal of Neuroscience

Volumn 35, Issue 16, 2015, Pages 6381-6393

  Kunis, Gilad ^a   Baruch, Kuti ^a   Miller, Omer ^a   Schwartz, Michal ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Amyotrophic lateral sclerosis; Autoimmunity; Choroid plexus; Neurodegeneration; T cells

Indexed keywords

CD11B ANTIGEN; CD4 ANTIGEN; COMPLEMENTARY DNA; GAMMA INTERFERON; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; SOMATOMEDIN C; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; COPPER ZINC SUPEROXIDE DISMUTASE; INSULIN-LIKE GROWTH FACTOR-1, MOUSE; MOG PROTEIN, MOUSE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; SUPEROXIDE DISMUTASE;

ADOPTIVE TRANSFER; ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL MIGRATION; CEREBROSPINAL FLUID; CHOROID PLEXUS; DISEASE COURSE; DNA SYNTHESIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; FLOW CYTOMETRY; GRIP STRENGTH TEST; HISTOLOGY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; RNA PURIFICATION; ANIMAL; CELL MOTION; CYTOLOGY; DISEASE MODEL; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; MUTATION; PATHOLOGY; PRIMARY CELL CULTURE; SPINAL CORD; T LYMPHOCYTE; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL MOVEMENT; CHOROID PLEXUS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; IMMUNIZATION; INSULIN-LIKE GROWTH FACTOR I; MACROPHAGES; MALE; MICE; MICE, TRANSGENIC; MUTATION; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PRIMARY CELL CULTURE; SPINAL CORD; SUPEROXIDE DISMUTASE; T-LYMPHOCYTES;

EID: 84929340491     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3644-14.2015     Document Type: Article

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