Polycystic ovaries and obesity

Best Practice and Research: Clinical Obstetrics and Gynaecology

Volumn 29, Issue 4, 2015, Pages 479-488

  Messinis, Ioannis E ^a   Messini, Christina I ^a   Anifandis, George ^a   Dafopoulos, Konstantinos ^a  

^a UNIVERSITY OF THESSALY   (Greece)

Author keywords

infertility; obesity; ovulation induction; polycystic ovaries; reproduction

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; AROMATASE INHIBITOR; CLOMIFENE CITRATE; FOLLITROPIN; INSULIN SENSITIZING AGENT; LEPTIN; LUTEINIZING HORMONE; METFORMIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; RESISTIN; RETINOL BINDING PROTEIN 4; ANTIDIABETIC AGENT;

ARTICLE; BARIATRIC SURGERY; DIET; DRUG EFFECT; DRUG USE; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; LAPAROSCOPIC OVARIAN DRILLING; LAPAROSCOPIC SURGERY; LIFESTYLE MODIFICATION; LUTEINIZING HORMONE RELEASE; OBESITY; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PRIORITY JOURNAL; REPRODUCTION; COMPLICATION; HYPERINSULINISM; INFERTILITY, FEMALE; INSULIN RESISTANCE; LIFESTYLE; METABOLISM; POLYCYSTIC OVARY SYNDROME; PROCEDURES;

ADIPOKINES; ADIPONECTIN; FEMALE; HUMANS; HYPERANDROGENISM; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INFERTILITY, FEMALE; INSULIN RESISTANCE; LEPTIN; LIFE STYLE; LUTEINIZING HORMONE; METFORMIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OBESITY; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; RESISTIN;

EID: 84929334035     PISSN: 15216934     EISSN: 15321932     Source Type: Journal    
DOI: 10.1016/j.bpobgyn.2014.11.001     Document Type: Article

References (92)

1. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) Hum Reprod 19 2004 41 47
2. S. Franks Polycystic ovary syndrome Trends Endocrinol Metab 1 1989 60 63
3. R. Azziz, L.A. Sanchez, and E.S. Knochenhauer Androgen excess in women: experience with over 1000 consecutive patients J Clin Endocrinol Metab 89 2004 453 462
4. S. Hahn, S. Tan, and S. Sack Prevalence of the metabolic syndrome in German women with polycystic ovary syndrome Exp Clin Endocrinol Diabetes 115 2007 130 135
5. E. Carmina, S. Bucchieri, and A. Esposito Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance J Clin Endocrinol Metab 92 2007 2500 2505
6. C.J. Brewer, and A.H. Balen The adverse effects of obesity on conception and implantation Reproduction 140 2010 347 364
7. P.K. Pradeep, X. Li, and H. Peegel Dihydrotestosterone inhibits granulosa cell proliferation by decreasing the cyclin D2 mRNA expression and cell cycle arrest at G1 phase Endocrinology 143 2002 2930 2935
8. S. Greisen, T. Ledet, and P. Ovesen Effects of androstenedione, insulin and luteinizing hormone on steroidogenesis in human granulosa luteal cells Hum Reprod 16 2001 2061 2065
9. A.J. Jakimiuk, S.R. Weitsman, and D.A. Magoffin 5alpha-reductase activity in women with polycystic ovary syndrome J Clin Endocrinol Metab 84 1999 2414 2418
10. S.S. Lim, R.J. Norman, and M.J. Davies The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis Obes Rev 14 2013 95 109
11. K. Dafopoulos, C. Venetis, and S. Pournaras Ovarian control of pituitary sensitivity of luteinizing hormone secretion to gonadotropin-releasing hormone in women with the polycystic ovary syndrome Fertil Steril 92 2009 1378 1380
12. C.A. Eagleson, M.B. Gingrich, and C.L. Pastor Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone J Clin Endocrinol Metab 85 2000 4047 4052
13. Y.L. Pagán, S.S. Srouji, and Y. Jimenez Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions J Clin Endocrinol Metab 91 2006 1309 1316
14. M.A. Lawson, S. Jain, and S. Sun Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women J Clin Endocrinol Metab 93 2008 2089 2096
15. G.A. Laughlin, A.J. Morales, and S.S. Yen Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia J Clin Endocrinol Metab 82 1997 1692 1696
16. S.G. Hillier Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis Hum Reprod 9 1994 188 191
17. D.S. Willis, H. Watson, and H.D. Mason Premature response to luteinizing hormone of granulosa cells from anovulatory women with polycystic ovary syndrome: relevance to mechanism of anovulation J Clin Endocrinol Metab 83 1998 3984 3991
18. L. Poretsky, N.A. Cataldo, and Z. Rosenwaks The insulin-related ovarian regulatory system in health and disease Endocr Rev 20 1999 535 582
19. A. Gambineri, C. Pelusi, and V. Vicennati Obesity and the polycystic ovary syndrome Int J Obes Relat Metab Disord 26 2002 883 896
20. C.J. Kelly, S.R. Stenton, and H. Lashen Insulin-like growth factor binding protein-1 in PCOS: a systematic review and meta-analysis Hum Reprod Update 17 2011 4 16
21. S. Rajaram, D.J. Baylink, and S. Mohan Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions Endocr Rev 18 1997 801 831
22. A.M. Clark, W. Ledger, and C. Galletly Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women Hum Reprod 10 1995 2705 2712
23. I.E. Messinis, and S.D. Milingos Leptin in human reproduction Hum Reprod Update 5 1999 52 63
24. T.M. Barber, and S. Franks Adipocyte biology in polycystic ovary syndrome Mol Cell Endocrinol 373 2013 68 76
25. E. Carmina, S. Bucchieri, and P. Mansueto Circulating levels of adipose products and differences in fat distribution in the ovulatory and anovulatory phenotypes of polycystic ovary syndrome Fertil Steril 91 4 Suppl. 2009 1332 1335
26. P.F. Svendsen, M. Christiansen, and P.L. Hedley Adipose expression of adipocytokines in women with polycystic ovary syndrome Fertil Steril 98 2012 235 241
27. K.A. Toulis, D.G. Goulis, and D. Farmakiotis Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis Hum Reprod Update 15 2009 297 307
28. S. Li, X. Huang, and H. Zhong Low circulating adiponectin levels in women with polycystic ovary syndrome: an updated meta-analysis Tumour Biol 35 2014 3961 3973
29. M.S. Ardawi, and A.A. Rouzi Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome Fertil Steril 83 2005 1708 1716
30. O. Pinhas-Hamiel, S. Singer, and N. Pilpel Adiponectin levels in adolescent girls with polycystic ovary syndrome Clin Endocrinol 71 2009 823 827
31. D.V. Lagaly, P.Y. Aad, and J.A. Grado-Ahuir Role of adiponectin in regulating ovarian theca and granulosa cell function Mol Cell Endocrinol 284 2008 38 45
32. H.F. Escobar-Morreale, and J.L. San Millán Abdominal adiposity and the polycystic ovary syndrome Trends Endocrinol Metab 18 2007 266 272
33. C.M. Steppan, S.T. Bailey, and S. Bhat The hormone resistin links obesity to diabetes Nature 409 2001 307 312
34. J. Zhang, L. Zhou, and L. Tang The plasma level and gene expression of resistin in polycystic ovary syndrome Gynecol Endocrinol 27 2011 982 987
35. K.M. Seow, C.C. Juan, and L.Y. Wu Serum and adipocyte resistin in polycystic ovary syndrome with insulin resistance Hum Reprod 19 2004 48 53
36. B. Pangaribuan, I. Yusuf, and M. Mansyur Serum adiponectin and resistin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome Ther Adv Endocrinol Metab 2 2011 235 245
37. A. Fukuhara, M. Matsuda, and M. Nishizawa Visfatin: a protein secreted by visceral fat that mimics the effects of insulin Science 307 2005 426 430
38. Y.H. Chang, D.M. Chang, and K.C. Lin Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta-analysis and systemic review Diabetes Metab Res Rev 27 2011 515 527
39. I. Kowalska, M. Straczkowski, and A. Nikolajuk Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome Hum Reprod 22 2007 1824 1829
40. Q. Yang, T.E. Graham, and N. Mody Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes Nature 436 2005 356 362
41. S. Tan, S. Hahn, and S. Benson Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance Eur J Endocrinol 157 2007 201 207
42. I.E. Messinis Ovulation induction: a mini review Hum Reprod 20 2005 2688 2697
43. Å. Nybacka, K. Carlström, and A. Ståhle Randomized comparison of the influence of dietary management and/or physical exercise on ovarian function and metabolic parameters in overweight women with polycystic ovary syndrome Fertil Steril 96 2011 1508 1513
44. Å. Nybacka, K. Carlström, and F. Fabri Serum antimüllerian hormone in response to dietary management and/or physical exercise in overweight/obese women with polycystic ovary syndrome: secondary analysis of a randomized controlled trial Fertil Steril 100 2013 1096 1102
45. A.D. Nascimento, L.A. Silva Lara, and A.C. Japur de Sá Rosa-e-Silva Effects of metformin on serum insulin and anti-Mullerian hormone levels and on hyperandrogenism in patients with polycystic ovary syndrome Gynecol Endocrinol 29 2013 246 249
46. C. Vosnakis, N.A. Georgopoulos, and D. Rousso Diet, physical exercise and Orlistat administration increase serum anti-Müllerian hormone (AMH) levels in women with polycystic ovary syndrome (PCOS) Gynecol Endocrinol 29 2013 242 245
47. S.M. Nelson, and R.F. Fleming The preconceptual contraception paradigm: obesity and infertility Hum Reprod 22 2007 912 915
48. Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Consensus on infertility treatment related to polycystic ovary syndrome Hum Reprod 23 2008 462 477
49. M.G. Hammond, J.K. Halme, and L.M. Talbert Factors affecting the pregnancy rate in clomiphene citrate induction of ovulation Obstet Gynecol 62 1983 196 202
50. E. Kousta, D.M. White, and S. Franks Modern use of clomiphene citrate in induction of ovulation Hum Reprod Update 3 1997 359 365
51. B. Imani, M.J. Eijkemans, and F.H. de Jong Free androgen index and leptin are the most prominent endocrine predictors of ovarian response during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility J Clin Endocrino Metab 85 2000 676 682
52. S. Palomba, A. Falbo, and F. Orio Jr. Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndrome Fertil Steril 91 2009 2557 2567
53. S. Palomba, A. Falbo, and F. Giallauria Six weeks of structured exercise training and hypocaloric diet increases the probability of ovulation after clomiphene citrate in overweight and obese patients with polycystic ovary syndrome: a randomized controlled trial Hum Reprod 25 2010 2783 2791
54. A. Requena, J. Herrero, J. Landeras Reproductive Endocrinology Interest Group of Spanish Society of Fertility Use of letrozole in assisted reproduction: a systematic review and meta-analysis Hum Reprod Update 14 2008 571 582
55. K.K. McKnight, J.L. Nodler, and J.J. Cooper Jr. Body mass index-associated differences in response to ovulation induction with letrozole Fertil Steril 96 2011 1206 1208
56. S. Christin-Maitre, J.N. Hugues Recombinant FSH Study Group A comparative randomized multicentric study comparing the step-up versus step-down protocol in polycystic ovary syndrome Hum Reprod 18 2003 1626 1631
57. R. Homburg, and C.M. Howles Low-dose FSH therapy for anovulatory infertility associated with polycystic ovary syndrome: rationale, results, reflections and refinements Hum Reprod Update 5 1999 493 499
58. I.E. Messinis, and S.D. Milingos Current and future status of ovulation induction in polycystic ovary syndrome Hum Reprod Update 3 1997 235 253
59. M.J. Eijkemans, B. Imani, and A.G. Mulders High singleton live birth rate following classical ovulation induction in normogonadotrophic anovulatory infertility (WHO 2) Hum Reprod 18 2003 2357 2362
60. D. Hamilton-Fairley, D. Kiddy, and H. Watson Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonadotrophin Br J Obstet Gynaecol 99 1992 128 131
61. A.H. Balen, M. Dresner, and E.M. Scott Should obese women with polycystic ovary syndrome receive treatment for infertility? BMJ 332 2006 434 435
62. B. Imani, M.J. Eijkemans, and G.H. Faessen Prediction of the individual follicle-stimulating hormone threshold for gonadotropin induction of ovulation in normogonadotropic anovulatory infertility: an approach to increase safety and efficiency Fertil Steril 77 2002 83 90
63. M. van Wely, B.C. Fauser, and J.S. Laven Validation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary syndrome Fertil Steril 86 2006 1710 1715
64. E.J. van Santbrink, M.J. Eijkemans, and N.S. Macklon FSH response-dose can be predicted in ovulation induction for normogonadotropic anovulatory infertility Eur J Endocrinol 147 2002 223 226
65. S.A. Amer, T.C. Li, and W.L. Ledger Ovulation induction using laparoscopic ovarian drilling in women with polycystic ovarian syndrome: predictors of success Hum Reprod 19 2004 1719 1724
66. E. Moll, P.M. Bossuyt, and J.C. Korevaar Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial BMJ 332 2006 1485
67. R.S. Legro, H.X. Barnhart, W.D. Schlaff Cooperative Multicenter Reproductive Medicine Network Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome N Engl J Med 356 2007 551 566
68. E. Moll, F. van der Veen, and M. van Wely The role of metformin in polycystic ovary syndrome: a systematic review Hum Reprod Update 13 2007 527 537
69. R. Pasquali, A. Gambineri, and D. Biscotti Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome J Clin Endocrinol Metab 85 2000 2767 2774
70. K.M. Hoeger, L. Kochman, and N. Wixom A randomized, 48-week, placebo-controlled trial of intensive lifestyle modification and/or metformin therapy in overweight women with polycystic ovary syndrome: a pilot study Fertil Steril 82 2004 421 429
71. B. Trolle, A. Flyvbjerg, and U. Kesmodel Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomized, double-blinded, placebo-controlled cross-over trial Hum Reprod 22 2007 2967 2973
72. N.P. Johnson, S. Bontekoe, and A.W. Stewart Analysis of factors predicting success of metformin and clomiphene treatment for women with infertility owing to PCOS-related ovulation dysfunction in a randomised controlled trial Aust N Z J Obstet Gynaecol 51 2011 252 256
73. M.L. Misso, M.F. Costello, and M. Garrubba Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis Hum Reprod Update 19 2013 2 11
74. E.M. Heijnen, M.J. Eijkemans, and E.G. Hughes A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome Hum Reprod Update 12 2006 13 21
75. K.L. Marquard, S.M. Stephens, and E.S. Jungheim Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles Fertil Steril 95 2011 2146 2149
76. T. Tang, J. Glanville, and N. Orsi The use of metformin for women with PCOS undergoing IVF treatment Hum Reprod 21 2006 1416 1425
77. L.O. Tso, M.F. Costello, and L.E. Albuquerque Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome Cochrane Database Syst Rev 15 2009 CD006105
78. S. Barr, K. Hart, and S. Reeves Habitual dietary intake, eating pattern and physical activity of women with polycystic ovary syndrome Eur J Clin Nutr 65 2011 1126 1132
79. L.J. Moran, S.K. Hutchison, and R.J. Norman Lifestyle changes in women with polycystic ovary syndrome Cochrane Database Syst Rev 7 2011 July 6 CD007506
80. R.L. Thomson, J.D. Buckley, and M. Noakes Heart rate recovery improves after weight loss in overweight and obese women with polycystic ovary syndrome Fertil Steril 93 2010 1173 1178
81. R.L. Thomson, J.D. Buckley, and G.D. Brinkworth Exercise for the treatment and management of overweight women with polycystic ovary syndrome: a review of the literature Obes Rev 12 2011 202 210
82. S.L. Kozica, A.A. Deeks, and M.E. Gibson-Helm Health-related behaviors in women with lifestyle-related diseases Behav Med 38 2012 65 73
83. R.L. Thomson, J.D. Buckley, and M. Noakes The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome J Clin Endocrinol Metab 93 2008 3373 3380
84. R.L. Thomson, G.D. Brinkworth, and M. Noakes The effect of diet and exercise on markers of endothelial function in overweight and obese women with polycystic ovary syndrome Hum Reprod 27 2012 2169 2176
85. A.E. Nieuwenhuis-Ruifrok, W.K. Kuchenbecker, and A. Hoek Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: systematic review and meta-analysis Hum Reprod Update 15 2009 57 68
86. T. Tang, J. Glanville, and C.J. Hayden Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study Hum Reprod 21 2006 80 89
87. K. Elkind-Hirsch, O. Marrioneaux, and M. Bhushan Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome J Clin Endocrinol Metab 93 2008 2670 2678
88. A. Lindholm, M. Bixo, and I. Björn Effect of sibutramine on weight reduction in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial Fertil Steril 89 2008 1221 1228
89. D. Panidis, D. Farmakiotis, and D. Rousso Obesity, weight loss, and the polycystic ovary syndrome: effect of treatment with diet and orlistat for 24 weeks on insulin resistance and androgen levels Fertil Steril 89 2008 899 906
90. D. Panidis, K. Tziomalos, and E. Papadakis The role of orlistat combined with lifestyle changes in the management of overweight and obese patients with polycystic ovary syndrome Clin Endocrinol 80 2004 432 438
91. H.F. Escobar-Morreale, J.I. Botella-Carretero, and F. Alvarez-Blasco The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery J Clin Endocrinol Metab 90 2005 6364 6369
92. S.M. Malik, and M.L. Traub Defining the role of bariatric surgery in polycystic ovarian syndrome patients World J Diabetes 3 2012 71 79