The role of orlistat combined with lifestyle changes in the management of overweight and obese patients with polycystic ovary syndrome

Clinical Endocrinology

Volumn 80, Issue 3, 2014, Pages 432-438

  Panidis, Dimitrios ^a   Tziomalos, Konstantinos ^a   Papadakis, Efstathios ^a   Chatzis, Panagiotis ^a   Kandaraki, Eleni A ^a   Tsourdi, Elena A ^a   Katsikis, Ilias ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; TESTOSTERONE; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD PRESSURE; BODY MASS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; EXERCISE; FEMALE; HUMAN; LIFESTYLE MODIFICATION; LOW CALORY DIET; MAJOR CLINICAL STUDY; OBESITY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; TESTOSTERONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; ANTI-OBESITY AGENTS; BODY MASS INDEX; CALORIC RESTRICTION; COMBINED MODALITY THERAPY; EXERCISE; FEMALE; HUMANS; LACTONES; LIFE STYLE; OBESITY; OVERWEIGHT; POLYCYSTIC OVARY SYNDROME; WEIGHT LOSS; WEIGHT REDUCTION PROGRAMS; YOUNG ADULT;

EID: 84897052079     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12305     Document Type: Article

References (38)

1. Goodarzi, M.O., Dumesic, D.A., Chazenbalk, G. et al. (2011) Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nature Reviews Endocrinology, 7, 219-231.
2. Lim, S.S., Norman, R.J., Davies, M.J. et al. (2013) The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis. Obesity Reviews, 14, 95-109.
3. Moran, L.J., Pasquali, R., Teede, H.J. et al. (2009) Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Fertility & Sterility, 92, 1966-1982.
4. Panidis, D., Tziomalos, K., Papadakis, E. et al. (2013) Lifestyle intervention and anti-obesity therapies in the polycystic ovary syndrome: impact on metabolism and fertility. Endocrine 2013 Apr 27 [Epub ahead of print].
5. Torgerson, J.S., Hauptman, J., Boldrin, M.N. et al. (2004) XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care, 27, 155-161.
6. Rucker, D., Padwal, R., Li, S.K. et al. (2007) Long term pharmacotherapy for obesity and overweight: updated meta-analysis. British Medical Journal, 335, 1194-1199.
7. Jayagopal, V., Kilpatrick, E.S., Holding, S. et al. (2005) Orlistat is as beneficial as metformin in the treatment of polycystic ovarian syndrome. Journal of Clinical Endocrinology & Metabolism, 90, 729-733.
8. Cho, L.W., Kilpatrick, E.S., Keevil, B.G. et al. (2009) Effect of metformin, orlistat and pioglitazone treatment on mean insulin resistance and its biological variability in polycystic ovary syndrome. Clinical Endocrinology, 70, 233-237.
9. Metwally, M., Amer, S., Li, T.C. et al. (2009) An RCT of metformin versus orlistat for the management of obese anovulatory women. Human Reproduction, 24, 966-975.
10. Ghandi, S., Aflatoonian, A., Tabibnejad, N. et al. (2011) The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study. Journal of Assisted Reproduction & Genetics, 28, 591-596.
11. Gambineri, A., Patton, L., Altieri, P. et al. (2012) Polycystic ovary syndrome is a risk factor for type 2 diabetes: results from a long-term prospective study. Diabetes, 61, 2369-2374.
12. Shaw, L.J., Bairey Merz, C.N., Azziz, R. et al. (2008) Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health-National Heart, Lung, and Blood Institute sponsored Women's Ischemia Syndrome Evaluation. Journal of Clinical Endocrinology & Metabolism, 93, 1276-1284.
13. Panidis, D., Farmakiotis, D., Rousso, D. et al. (2008) Obesity, weight loss, and the polycystic ovary syndrome: effect of treatment with diet and orlistat for 24 weeks on insulin resistance and androgen levels. Fertility & Sterility, 89, 899-906.
14. Vosnakis, C., Georgopoulos, N.A., Rousso, D. et al. (2013) Diet, physical exercise and Orlistat administration increase serum Anti-Müllerian Hormone (AMH) levels in women with polycystic ovary syndrome (PCOS). Gynecological Endocrinology, 29, 242-245.
15. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Human Reproduction, 19, 41-47.
16. Alberti, K.G., Eckel, R.H. & Grundy, S.M. et al.; International Diabetes Federation Task Force on Epidemiology and Prevention; Hational Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity. (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation, 120, 1640-1645.
17. Friedewald, W.T., Levy, R.I. & Fredrickson, D.S. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18, 499-502.
18. Carter, G.D., Holland, S.M., Alaghband-Zadeh, J. et al. (1983) Investigation of hirsutism: testosterone is not enough. Annals of Clinical Biochemistry, 20, 262-263.
19. Matthews, D., Hosker, J., Rudenski, A. et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412-419.
20. Katz, A., Nambi, S.S., Mather, K. et al. (2000) Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. Journal of Clinical Endocrinology & Metabolism, 85, 2402-2410.
21. Thomson, R.L., Buckley, J.D., Noakes, M. et al. (2008) The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome. Journal of Clinical Endocrinology & Metabolism, 93, 3373-3380.
22. Palomba, S., Falbo, A., Giallauria, F. et al. (2010) Six weeks of structured exercise training and hypocaloric diet increases the probability of ovulation after clomiphene citrate in overweight and obese patients with polycystic ovary syndrome: a randomized controlled trial. Human Reproduction, 25, 2783-2791.
23. Douglas, C.C., Gower, B.A., Darnell, B.E. et al. (2006) Role of diet in the treatment of polycystic ovary syndrome. Fertility & Sterility, 85, 679-688.
24. Randeva, H.S., Lewandowski, K.C., Drzewoski, J. et al. (2002) Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome. Journal of Clinical Endocrinology & Metabolism, 87, 4496-4501.
25. Stener-Victorin, E., Baghaei, F., Holm, G. et al. (2012) Effects of acupuncture and exercise on insulin sensitivity, adipose tissue characteristics, and markers of coagulation and fibrinolysis in women with polycystic ovary syndrome: secondary analyses of a randomized controlled trial. Fertility & Sterility, 97, 501-508.
26. Matsuda, M. & DeFronzo, R.A. (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care, 22, 1462-1470.
27. Tziomalos, K., Athyros, V.G., Karagiannis, A. et al. (2011) Dyslipidemia induced by drugs used for the prevention and treatment of vascular diseases. Open Cardiovascular Medicine Journal, 5, 85-89.
28. Wild, R.A., Carmina, E., Diamanti-Kandarakis, E. et al. (2010) Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society. Journal of Clinical Endocrinology & Metabolism, 95, 2038-2049.
29. Gambineri, A., Repaci, A., Patton, L. et al. (2009) Prominent role of low HDL-cholesterol in explaining the high prevalence of the metabolic syndrome in polycystic ovary syndrome. Nutrition Metabolism and Cardiovascular Diseases, 19, 797-804.
30. Tai, K., Gentilcore, D., Jones, K.L. et al. (2011) Orlistat accentuates the fat-induced fall in blood pressure in older adults. British Journal of Nutrition, 106, 417-424.
31. Turer, C.B., Bernstein, I.H., Edelman, D.E. et al. (2012) Low HDL predicts differential blood pressure effects from two weight-loss approaches: a secondary analysis of blood pressure from a randomized, clinical weight-loss trial. Diabetes, Obesity and Metabolism, 14, 375-378.
32. Lowenstein, C.J. & Cameron, S.J. (2010) High-density lipoprotein metabolism and endothelial function. Current Opinion in Endocrinology, Diabetes and Obesity, 17, 166-170.
33. Siebenhofer, A., Jeitler, K., Berghold, A. et al. (2011) Long-term effects of weight-reducing diets in hypertensive patients. Cochrane Database of Systematic Reviews, 9, CD008274.
34. Livadas, S., Chaskou, S., Kandaraki, A.A. et al. (2011) Anxiety is associated with hormonal and metabolic profile in women with polycystic ovarian syndrome. Clinical Endocrinology, 75, 698-703.
35. Weiner, C.L., Primeau, M. & Ehrmann, D.A. (2004) Androgens and mood dysfunction in women: comparison of women with polycystic ovarian syndrome to healthy controls. Psychosomatic Medicine, 66, 356-362.
36. Jeanes, Y.M., Barr, S., Smith, K. et al. (2009) Dietary management of women with polycystic ovary syndrome in the United Kingdom: the role of dietitians. Journal of Human Nutrition and Dietetics, 22, 551-558.
37. Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2008) Consensus on infertility treatment related to polycystic ovary syndrome. Human Reproduction, 23, 462-477.
38. Norman, R.J., Dewailly, D., Legro, R.S. et al. (2007) Polycystic ovary syndrome. Lancet, 370, 685-697.