Premature response to luteinizing hormone of granulosa cells from anovulatory women with polycystic ovary syndrome: Relevance to mechanism of anovulation

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 11, 1998, Pages 3984-3991

  Willis, Debbie S ^a   Watson, Hazel ^a   Mason, Helen D ^a   Galea, Ray ^b   Brincat, Mark ^b   Franks, Stephen ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MALTA   (Malta)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; PROGESTERONE;

ADULT; ANOVULATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ESTROGEN SYNTHESIS; FEMALE; GRANULOSA CELL; HORMONE RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; OVARY POLYCYSTIC DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; RADIOIMMUNOASSAY;

FALLOPIA;

EID: 0031763879     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.11.3984     Document Type: Article

References (40)

1. Franks S. 1995 Polycystic ovary syndrome. N Engl J Med. 333:853-861.
2. Dunaif A, Graf M, Mandell J, Laumas V, Dobransky A. 1987 Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance and/or hyperinsulinemia. J Clin Endocrinol Metab. 65:499-507.
3. Conway GS, Jacobs HS, Holly JMP, Wass JAH. 1990 Effects of luteinizing hormone, insulin, insulin-like growth factor-I and insulin-like growth factor small binding protein-1 in the polycystic ovary syndrome. Clin Endocrinol (Oxf). 33:593-603.
4. Sharp PS, Kiddy DS, Reed MJ, Anyaoku V, Johnston DG, Franks S. 1991 Correlation of plasma insulin and insulin-like growth factor-I with indices of androgen transport and metabolism in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 35:253-257.
5. Robinson S, Kiddy D, Gelding SV, et al. 1993 The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clin Endocrinol (Oxf). 39:351-355.
6. Polson DW, Kiddy DS, Mason HD, Franks S. 1989 Induction of ovulation with clomiphene citrate in women: the difference between responders and non-responders. Fertil Steril. 51:30-34.
7. Kiddy DS, Sharp PS, White DM, et al. 1990 Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: an analysis of 263 consecutive cases. Clin Endocrinol (Oxf). 32:213-220.
8. Hamilton-Fairley D, Kiddy D, Watson H, Paterson C, Franks S. 1992 Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonadotrophin. Br J Obstet Gynaecol. 99:128-131.
9. Kiddy DS, Hamilton-Fairley D, Bush A, et al. 1992 Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 36:105-111.
10. Pasquali R, Antenucci D, Casimirri F, et al. 1989 Clinical and hormonal characteristics of obese amenorrheic hyperandrogenic women before and after weight loss. J Clin Endocrinol Metab. 68:173-179.
11. Nestler JE, Jakubowicz DJ. 1996 Decreases in ovarian cytochrome P450c17α activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. N Engl J Med. 335:617-623.
12. Dunaif A, Scott D, Finegood D, Quintana B, Whitcomb R. 1996 The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. J Clin Endocrinol Metab. 81:3299-3306.
13. Willis D, Franks S. 1995 Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-1 insulin-like growth factor receptor. J Clin Endocrinol Metab. 80:3788-3790.
14. Willis DS, Mason HD, Gilling-Smith C, Franks S. 1996 Modulation by insulin of follicle stimulating hormone and luteinising hormone actions in human granulosa cells of normal and polycystic ovaries. J Clin Endocrinol Metab. 81:302-309.
15. Adams J, Franks S, Polson DW, et al. 1985 Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotrophin releasing hormone. Lancet. 2:1375-1379.
16. Mason HD, Willis DS, Beard RW, Winston RML, Margara R, Franks S. 1994 Estradiol production by granulosa cells of normal and polycystic ovaries (PCO): relationship to menstrual history and concentrations of gonadotropins and sex steroids in follicular fluid. J Clin Endocrinol Metab. 79:1355-1360.
17. Gilling-Smith C, Willis DS, Beard RW, Franks S. 1994 Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries. J Clin Endocrinol Metab. 79:1158-1165.
18. 17a. Ferguson KM, Hayes M, Jeffcote SL. 1992 A standardised multicentre procedure for plasma gonadotrophin radioimmunoassay. Ann Clin Biochem. 19:358-361.
19. McNatty KP, Baird DT. 1978 Relationship between follicle-stimulating hormone, androstenedione and oestradiol in human follicular fluid. J Endocrinol. 76:527-531.
20. McNatty KP, Smith DM, Osathanondh R, Ryan KJ. 1979 The human antral follicle: functional correlates of growth and atresia. Ann Biol Anim Biochem Biophys. 19:1547-1558.
21. Kammerman S, Ross J. 1975 Increase in numbers of gonadotropin receptors on granulosa cells during follicle maturation. J Clin Endocrinol Metab. 41:546-551.
22. Nimrod A, Bedrak E, Lamprecht SA. 1977 Appearance of LH-receptors and LH-stimulatable cyclic AMP accumulation in granulosa cells during follicular maturation in the rat ovary. Biochem Biophys Res Commun. 78:977-984.
23. Wang C, Hsueh AJW, Erickson GF. 1981 LH stimulation of estrogen secretion by cultured rat granulosa cells. Mol Cell Endocrinol. 24:17-28.
24. Shima K, Kitayama S, Nakano R. 1987 Gonadotropin binding sites in human ovarian follicles and corpora lutea during the menstrual cycle. Obstet Gynecol. 69:800-806.
25. Shaw HJ, Hillier SG, Hodges JK. 1989 Developmental changes in luteinizing hormone/human chorionic gonadotropin steroidogenic responsiveness in marmoset granulosa cells: effects of follicle stimulating hormone and androgens. Endocrinology. 124:1669-1677.
26. Baird DT. 1987 A model for follicular selection and ovulation: lessons from superovulation. J Steroid Biochem. 27:15-23.
27. Hillier SG. 1994 Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis. Hum Reprod. 9:188-191.
28. Friedrich F, Kemeter P, Salser H, Breitenecker G. 1975 Ovulation inhibition with human chorionic gonadotrophin. Acta Endocrinol (Copenh). 78:332-342.
29. Chappel SC, Howles C. 1991 Reevaluation of the roles of luteinizing hormone and follicle-stimulating hormone in the ovulatory process. Hum Reprod. 6:1206-1212.
30. Shoham Z, Jacobs HS, Insler V. 1993 Luteinizing hormone: its role, mechanism of action and detrimental effects when hypersecreted during the follicular phase. Fertil Steril. 59:1153-1161.
31. McNatty KP, Sawers RS. 1975 Relationship between the endocrine environment within the Graafian follicle and the subsequent rate of progesterone secretion by human granulosa cells in vitro. J Endocrinol. 66:391-400.
32. Yong EL, Baird DT, Yates R, Reichert Jr LE, Hillier SG. 1992 Hormonal regulation of the growth and steroidogenic function of human granulosa cells. J Clin Endocrinol Metab. 74:842-849.
33. Yong EL, Baird DT, Hillier SG. 1992 Mediation of gonadotrophin-stimulated growth and differentiation of human granulosa cells by adenosine-3′,5′-monophosphate: one molecule, two messages. Clin Endocrinol (Oxf). 37:51-58.
34. McNatty KP, Smith DM, Makris A, Osathanondh R, Ryan KJ. 1979 The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro. J Clin Endocrinol Metab. 49:851-860.
35. Frishman GN, Luciano AA, Peluso JJ. 1992 Effect of the ratio of follicle-stimulating hormone to luteinizing hormone on rat granulosa cell proliferation and oestradiol-17β secretion. Hum Reprod. 7:1073-1078.
36. Holte J, Bergh T, Gennarelli G, Wide L. 1994 The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women. Clin Endocrinol (Oxf). 41:473-81.
37. Hillier SG, de Zwart FA. 1982 Androgen/antiandrogen modulation of cyclic AMP-induced steroidogenesis during granulosa cell differentiation in tissue culture. Mol Cell Endocrinol. 28:347-361.
38. Hillier SG. 1987 Intrafollicular paracrine function of ovarian androgen. J Steroid Biochem. 27:351-357.
39. Agarwal SK, Judd HL, Magoffin DA. 1996 A mechanism for the suppression of estrogen production in polycystic ovary syndrome. J Clin Endocrinol Metab. 81:3686-3691.
40. Giudice LC. 1992 Insulin-like growth factors, and ovarian follicular development. Endocr Rev. 13:641-669.