5α-Reductase activity in women with polycystic ovary syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 7, 1999, Pages 2414-2418

  Jakimiuk, Artur J ^b   Weitsman, Stacy R ^a   Magoffin, Denis A ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MESSENGER RNA; OXIDOREDUCTASE; ANDROSTANOLONE; ISOENZYME; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GRANULOSA CELL; HUMAN; HUMAN TISSUE; OVARY POLYCYSTIC DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; THECA CELL; ADULT; ENZYMOLOGY; GENE EXPRESSION; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

FALLOPIA;

ADULT; DIHYDROTESTOSTERONE; FEMALE; GENE EXPRESSION; GRANULOSA CELLS; HUMANS; ISOENZYMES; POLYCYSTIC OVARY SYNDROME; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TESTOSTERONE; TESTOSTERONE 5-ALPHA-REDUCTASE; THECA CELLS;

EID: 0033237665     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.84.7.5863     Document Type: Article

References (35)

1. Polycystic ovaries-a common finding in normal women
2. A disorder without identity: 'HCA,' 'PCO,' 'PCOD,' 'PCOS,' 'SLS'. What are we to call it?!
3. New data on follicle cells in polycystic ovaries: A proposed mechanism for the genesis of cystic follicles
4. Dynamics of follicular growth in the human: A model from preliminary results
5. A mechanism for the suppression of estrogen production in polycystic ovary syndrome
6. Alterations in granulosa cell aromatase activity accompanying preovulatory follicular development in the rat ovary with evidence that 5α-reduced C19 steroids inhibit the aromatase reaction in vitro
7. Metabolism of androstenedione by human ovarian tissues in vitro with particular reference to reductase and aromatase activity
8. Steroid 5α-reductase: Two genes/two enzymes
9. The molecular genetics of steroid 5α-reductases
10. Characterization and chromosomal mapping of human steroid 5α-reductase gene and pseudogene and mapping of the mouse homologue
11. Genetic and pharmacological evidence for more than one human steroid 5α-reductase
12. Steroid 5α-reductase 2 deficiency
13. Tissue distribution and ontogeny of steroid 5α-reductase isozyme expression
14. 5α-Reductase 1 and 2 expression in stroma and corpus luteum as compared to neonatal foreskin
15. Fluorometric quantification of DNA in cells and tissues
16. Structural and biochemical properties of cloned and espressed human and rat steroid 5α-reductases
17. Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism
18. Gene splicing by overlap extension: Tailor-made genes using the polymerase chain reaction
19. Tissue distribution and kinetic characteristics of rat steroid 5α-reductase
20. 17-20 lyase activity in rat ovarian theca-interstitial cells
21. 5α-Reductase activity in polycystic ovary syndrome
22. Follicle-stimulating hormone inhibits granulosa cell 5α-reductase activity
23. Hormonal regulation of activites of 4-ene-5β and 5α-reductases and 17β-ol-dehydrogenase in immature golden hamster ovary
24. Androgen induction of steroid 5α-reductase may be mediated via insulin-like growth factor-I
25. Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease
26. Follicular fluid concentrations of insulin-like growth factor 1, epidermal growth factor, transforming growth factor-α and sex-steroids in volume matched normal and polycystic human follicles
27. Feed-forward control of prostate growth: Dihydrotestosterone induces expression of its own biosynthetic enzyme, steroid 5α-reductase
28. Androgens stimulate early stages of follicular growth in the primate ovary
29. Effect of androgens on the development of mouse follicles growing in vitro
30. Aromatase messenger ribonucleic acid expression in individual follicles from polycystic ovaries
31. Inverse relationship between ovarian aromatase cytochrome P450 and 5α-reductase enzyme activities and mRNA levels during the estrous cycle in the rat
32. Expression cloning and regulation of steroid 5α-reductase, an enzyme essential for male sexual differentiation
33. Androgens and progestins in the human ovarian follicle: Differences in the evolution of preovulatory, healthy nonovulatory, and atretic follicles
34. The microenvironment of the human antral follicle: Interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro
35. In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol